World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
15250
World Ranking
9137
National Ranking
4058

Overview

Michael J. Kruhlak is affiliated with the National Institutes of Health in the United States. Their research primarily spans the areas of biochemistry, genetics, and molecular biology, with a notable focus on molecular biology, oncology, immunology, cell biology, and genetics. The scientist has contributed extensively to topics such as RNA research and splicing, pluripotent stem cells research, CRISPR and genetic engineering, RNA modifications and cancer, epigenetics and DNA methylation, DNA repair mechanisms, and genetics and neurodevelopmental disorders.

Kruhlak's recent scholarly output includes several publications with varying citation counts, indicating an active engagement in multiple research domains. Notable papers include:

  • "ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer" (2021, Nature Communications)
  • "Active DNA demethylation promotes cell fate specification and the DNA damage response" (2022, Science)
  • "IDH1 mutations induce organelle defects via dysregulated phospholipids" (2021, Nature Communications)
  • "CTCF is a barrier for 2C-like reprogramming" (2021, Nature Communications)
  • "Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response" (2021, Nature Communications)

The scientist has frequently published in several journals, particularly:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cancer Research
  • Thyroid
  • Nucleic Acids Research

Collaboration plays a considerable role in their work. Key frequent co-authors include:

  • Andy D. Tran
  • Raj Chari
  • Sergio Ruiz
  • Steven D. Cappell
  • Sheue-yann Cheng

The range of research areas and topics, supported by evidence from the scientist's publication and collaboration record, portrays a career focused on understanding complex biological processes at molecular and genetic levels. This includes ongoing investigation into mechanisms of cancer biology, stem cell behavior, epigenetic regulation, and the molecular underpinnings guiding DNA repair and cell fate decisions.

Best Publications

  • Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

    Arkady Celeste;Oscar Fernandez-Capetillo;Michael J. Kruhlak;Duane R. Pilch

  • Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

    Michael J. Kruhlak;Arkady Celeste;Graham Dellaire;Oscar Fernandez-Capetillo

  • Inhibition of the intestinal glucose transporter GLUT2 by flavonoids

    Oran Kwon;Peter Eck;Shenglin Chen;Christopher P. Corpe

  • T cell stemness and dysfunction in tumors are triggered by a common mechanism.

    Suman Kumar Vodnala;Robert Eil;Rigel J. Kishton;Madhusudhanan Sukumar

  • TLR9 Is Localized in the Endoplasmic Reticulum Prior to Stimulation

    Cynthia A. Leifer;Margaret N. Kennedy;Alessandra Mazzoni;ChangWoo Lee

  • Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals.

    Jung-Ae Kim;Michael Kruhlak;Farokh Dotiwala;André Nussenzweig

  • 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions

    Elsa Callen;Michela Di Virgilio;Michael J. Kruhlak;Maria Nieto-Soler

  • 53BP1 facilitates long-range DNA end-joining during V(D)J recombination

    Simone Difilippantonio;Eric Gapud;Nancy Wong;Ching Yu Huang

  • A multiprotein supercomplex controlling oncogenic signalling in lymphoma

    James D. Phelan;Ryan M. Young;Daniel E. Webster;Sandrine Roulland;Sandrine Roulland

  • Regulation of Histone Deacetylase 4 by Binding of 14-3-3 Proteins

    Audrey H. Wang;Michael J. Kruhlak;Jiong Wu;Nicholas R. Bertos

  • The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.

    Michael Kruhlak;Elizabeth E. Crouch;Marika Orlov;Carolina Montaño

  • Cooperative Epigenetic Modulation by Cancer Amplicon Genes

    Lixin Rui;N. C.Tolga Emre;Michael J. Kruhlak;Hye Jung Chung

  • Basis of CTLA-4 function in regulatory and conventional CD4+ T cells

    Xuguang Tai;François Van Laethem;Leonid Pobezinsky;Terry Guinter

  • Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

    Simone Difilippantonio;Arkady Celeste;Oscar Fernandez-Capetillo;Hua-Tang Chen

  • Regulation of global acetylation in mitosis through loss of histone acetyltransferases and deacetylases from chromatin.

    Michael J. Kruhlak;Michael J. Hendzel;Wolfgang Fischle;Nicholas R. Bertos

  • Reduced mobility of the alternate splicing factor (ASF) through the nucleoplasm and steady state speckle compartments.

    Michael J. Kruhlak;Melody A. Lever;Wolfgang Fischle;Eric Verdin

  • Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma

    Laurence Lamy;Vu N. Ngo;N.C. Tolga Emre;Arthur L. Shaffer

  • Differential expression of IFN-α and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients

    Jean-Philippe Herbeuval;Jakob Nilsson;Adriano Boasso;Andrew W. Hardy

  • A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance.

    Simran Khurana;Michael J. Kruhlak;Jeongkyu Kim;Andy D. Tran

  • Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis

    Harald F Langer;Eun Young Choi;Eun Young Choi;Eun Young Choi;Hong Zhou;Rebecca Schleicher

Frequent Co-Authors

André Nussenzweig
André Nussenzweig National Institutes of Health
Zhi-Ming Zheng
Zhi-Ming Zheng National Institutes of Health
David P. Bazett-Jones
David P. Bazett-Jones University of Calgary
Michael J. Hendzel
Michael J. Hendzel University of Alberta
Elsa Callen
Elsa Callen National Institutes of Health
Nicholas P. Restifo
Nicholas P. Restifo National Institutes of Health
Stephen Shaw
Stephen Shaw National Institutes of Health
Louis M. Staudt
Louis M. Staudt National Institutes of Health
Lionel Feigenbaum
Lionel Feigenbaum Science Applications International Corporation (United States)
Eun-Young Choi
Eun-Young Choi Vanderbilt University

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