World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
21696
World Ranking
3932
National Ranking
292

Overview

Hirota Fujiki is affiliated with the National Cancer Research Institute in the United Kingdom. Their research spans several areas within biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology, oncology, surgery, and cancer research.

The scientist's work primarily addresses topics related to Helicobacter pylori-associated gastroenterology studies, cancer-related gene regulation, epigenetics and DNA methylation, cancer molecular pathways, and the interface between cancer, lipids, and metabolism.

Recent papers authored by Hirota Fujiki include the following:

  • Role of TNF-α-Inducing Protein Secreted by Helicobacter pylori as a Tumor Promoter in Gastric Cancer and Emerging Preventive Strategies, 2021, published in Toxins
  • Cancer progression by the okadaic acid class of tumor promoters and endogenous protein inhibitors of PP2A, SET and CIP2A, 2023, published in Journal of Cancer Research and Clinical Oncology

Frequent co-authors collaborating with Hirota Fujiki include:

  • Masami Suganuma
  • Tatsuro Watanabe
  • Eisaburo Sueoka
  • In Kyoung Lim
  • Atsumasa Komori

Publication venues where Hirota Fujiki's work has appeared include:

  • Toxins
  • Journal of Cancer Research and Clinical Oncology

The focus of Hirota Fujiki's research encompasses detailed studies of molecular pathways involved in cancer and the role of specific proteins and tumor promoters in cancer progression. The work on Helicobacter pylori explores the bacterium's secreted proteins and their contribution to gastric cancer development, while other investigations address the impact of tumor promoters such as okadaic acid and endogenous inhibitors of protein phosphatase 2A (PP2A).

Overall, Hirota Fujiki's contributions lie at the intersection of microbiology, molecular cancer biology, and the biochemical mechanisms underlying tumor progression and prevention strategies.

Best Publications

  • Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR.

    Rie Nishiwaki-Matsushima;Tetsuya Ohta;Shinji Nishiwaki;Masami Suganuma

  • Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter

    Masami Suganuma;Hirota Fujiki;Hiroko Suguri;Shigeru Yoshizawa

  • Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity.

    Shigeru Yoshizawa;Rie Matsushima;Mariyo F. Watanabe;Ken-ichi Harada

  • Wide Distribution of [3H](-)-epigallocatechin Gallate, a Cancer Preventive Tea Polyphenol, in Mouse Tissue

    Masami Suganuma;Sachiko Okabe;Masumi Oniyama;Yukiko Tada

  • Essential Role of Tumor Necrosis Factor α (TNF-α) in Tumor Promotion as Revealed by TNF-α-deficient Mice

    Masami Suganuma;Sachiko Okabe;Michael W. Marino;Ayako Sakai

  • Antitumor promoting activity of (−)-epigallocatechin gallate, the main constituent of “Tannin” in green tea

    Shigeru Yoshizawa;Takahiko Horiuchi;Hirota Fujiki;Takashi Yoshida

  • Synergistic effects of (--)-epigallocatechin gallate with (--)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9.

    Masami Suganuma;Sachiko Okabe;Yasuko Kai;Naoko Sueoka

  • Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters

    Hirota Fujiki;Masami Mori;Michie Nakayasu;Masaaki Terada

  • Green tea and cancer chemoprevention.

    Masami Suganuma;Sachiko Okabe;Naoko Sueoka;Eisaburo Sueoka

  • Effect of (-)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines.

    Shun'ichiro Taniguchi;Hirota Fujiki;Hiroaki Kobayashi;Hiroki Go

  • New classes of tumor promoters: teleocidin, aplysiatoxin, and palytoxin.

    Hirota Fujiki;Takashi Sugimura

  • Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor

    B Friedman;A R Frackelton;A H Ross;J M Connors

  • In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblasts

    Rie Matsushima;Shigeru Yoshizawa;Mariyo F. Watanabe;Ken-ichi Harada

  • Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study.

    Masahito Shimizu;Yasushi Fukutomi;Mitsuo Ninomiya;Kazuo Nagura

  • A New Function of Green Tea: Prevention of Lifestyle‐related Diseases

    Naoko Sueoka;Masami Suganuma;Eisaburo Sueoka;Sachiko Okabe

  • Activation of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin.

    Hirota Fujiki;Yasushi Tanaka;Ryohei Miyake;Ushio Kikkawa

  • Mechanisms of Growth Inhibition of Human Lung Cancer Cell Line, PC‐9, by Tea Polyphenols

    Sachiko Okabe;Masami Suganuma;Moriaki Hayashi;Eisaburo Sueoka

  • Two stages of cancer prevention with green tea.

    Hirota Fujiki

  • Inhibitory effect of (-)-epigallocatechin gallate on carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine in mouse duodenum.

    Yoshihiro Fujita;Tetsuro Yamane;Masumi Tanaka;Katsuya Kuwata

  • Calyculin A, an Inhibitor of Protein Phosphatases, a Potent Tumor Promoter on CD-1 Mouse Skin

    Masami Suganuma;Hirota Fujiki;Hiroko Furuya-Suguri;Shigeru Yoshizawa

Frequent Co-Authors

Takashi Sugimura
Takashi Sugimura National Cancer Centre
Richard E. Moore
Richard E. Moore University of Hawaii at Manoa
Koichi Shudo
Koichi Shudo University of Tokyo
Marsha Rich Rosner
Marsha Rich Rosner University of Chicago
Hoyoku Nishino
Hoyoku Nishino Kyoto Prefectural University of Medicine
Lawrence Levine
Lawrence Levine Brandeis University
Makoto Ojika
Makoto Ojika Nagoya University
Kiyoyuki Yamada
Kiyoyuki Yamada Nagoya University
Akio Iwashima
Akio Iwashima Kyoto Prefectural University of Medicine
Yukio Imanishi
Yukio Imanishi Kyoto University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Hirota Fujiki

Trending Scientists