World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
47
Citations
12430
World Ranking
2717
National Ranking
1317

Overview

Elsa Callen is affiliated with the National Institutes of Health in the United States. Their research portfolio includes extensive work in the fields of Biochemistry, Genetics and Molecular Biology, with additional contributions in Medicine.

Their primary subfields of study encompass Molecular Biology, Oncology, Hematology, Genetics, and Plant Science. The main topics addressed in their research involve:

  • DNA Repair Mechanisms
  • PARP inhibition in cancer therapy
  • CRISPR and Genetic Engineering
  • Genomics and Chromatin Dynamics
  • Epigenetics and DNA Methylation
  • Acute Myeloid Leukemia Research
  • Chromosomal and Genetic Variations

Elsa Callen has published multiple papers, with recent notable works including:

  • "Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance," 2021, Nature Communications
  • "Neuronal enhancers are hotspots for DNA single-strand break repair," 2021, Nature
  • "Repeat expansions confer WRN dependence in microsatellite-unstable cancers," 2020, Nature
  • "ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis," 2020, Nature Communications
  • "Active DNA demethylation promotes cell fate specification and the DNA damage response," 2022, Science

The scientist often collaborates with other researchers, with frequent co-authors including André Nussenzweig, Wei Wu, Dali Zong, Raphael Pavani, and William J. Nathan. Their work has appeared predominantly in venues such as Molecular Cell, bioRxiv (Cold Spring Harbor Laboratory), Nature, Nature Communications, and Science.

Best Publications

  • 53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

    Samuel F. Bunting;Elsa Callén;Nancy Wong;Hua Tang Chen

  • Replication fork stability confers chemoresistance in BRCA-deficient cells

    Arnab Ray Chaudhuri;Elsa Callen;Xia Ding;Ewa Gogola

  • AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations

    Davide F. Robbiani;Anne Bothmer;Elsa Callen;Bernardo Reina-San-Martin

  • A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

    Gunnar Schotta;Roopsha Sengupta;Roopsha Sengupta;Stefan Kubicek;Stephen Malin

  • Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

    Jacqueline H. Barlow;Robert B. Faryabi;Elsa Callén;Nancy Wong

  • Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

    Michela Di Virgilio;Elsa Callen;Arito Yamane;Wenzhu Zhang

  • Role of genomic instability and p53 in AID-induced c-myc-Igh translocations

    Almudena Rodriguez Ramiro;Mila Jankovic;Elsa Callen;Simone Difilippantonio

  • 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions

    Elsa Callen;Michela Di Virgilio;Michael J. Kruhlak;Maria Nieto-Soler

  • Genome Organization Drives Chromosome Fragility

    Andres Canela;Yaakov Maman;Seolkyoung Jung;Nancy Wong

  • 53BP1 facilitates long-range DNA end-joining during V(D)J recombination

    Simone Difilippantonio;Eric Gapud;Nancy Wong;Ching Yu Huang

  • BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair.

    Samuel F. Bunting;Elsa Callén;Marina L. Kozak;Jung Min Kim

  • Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.

    Anne Bothmer;Davide F. Robbiani;Michela Di Virgilio;Samuel F. Bunting

  • Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes

    Elsa Callén;Mila Jankovic;Nancy Wong;Shan Zha

  • Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.

    Diana Zatreanu;Helen M. R. Robinson;Omar Alkhatib;Marie Boursier

  • DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

    Margarida A. Santos;Robert B. Faryabi;Aysegul V. Ergen;Amanda M. Day

  • ATM Prevents the Persistence and Propagation of Chromosome Breaks in Lymphocytes

    Elsa Callén;Mila Jankovic;Simone Difilippantonio;Jeremy A. Daniel

  • Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma.

    Davide F. Robbiani;Stephanie Deroubaix;Niklas Feldhahn;Thiago Y. Oliveira

  • Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse.

    Anthony Tubbs;Sriram Sridharan;Niek van Wietmarschen;Yaakov Maman

  • Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.

    Andres Canela;Yaakov Maman;Shar-yin N. Huang;Gordana Wutz

  • Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability

    Massimo Bogliolo;Alex Lyakhovich;Elsa Callén;Maria Castellà

Frequent Co-Authors

André Nussenzweig
André Nussenzweig National Institutes of Health
Michel C. Nussenzweig
Michel C. Nussenzweig Rockefeller University
Jordi Surrallés
Jordi Surrallés Autonomous University of Barcelona
Oscar Fernandez-Capetillo
Oscar Fernandez-Capetillo Spanish National Cancer Research Centre
Barry P. Sleckman
Barry P. Sleckman University of Alabama at Birmingham
Ricard Marcos
Ricard Marcos Autonomous University of Barcelona
Amadeu Creus
Amadeu Creus Autonomous University of Barcelona
Michael J. Kruhlak
Michael J. Kruhlak National Institutes of Health
Davide F. Robbiani
Davide F. Robbiani Universita della Svizzera Italiana
Detlev Schindler
Detlev Schindler University of Würzburg

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