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Molecular Biology

D-Index
64
Citations
19864
World Ranking
1714
National Ranking
865

Overview

Rafael Casellas is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research spans the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine, with a particular focus on Molecular Biology and Immunology. Their work also includes contributions to Plant Science, Infectious Diseases, and Radiology, Nuclear Medicine and Imaging.

Casellas's main research topics include:

  • Genomics and Chromatin Dynamics
  • RNA Research and Splicing
  • DNA Repair Mechanisms
  • SARS-CoV-2 and COVID-19 Research
  • Monoclonal and Polyclonal Antibodies Research
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses

Their recent papers, reflecting their research scope, include the following:

  • mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants, 2021, Nature
  • Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants, 2021, Nature
  • Neuronal enhancers are hotspots for DNA single-strand break repair, 2021, Nature
  • mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning, 2020, Nature

Their frequent co-authors include:

  • Jenna Ariel Lieberman
  • Jianliang Xu
  • A. Conte
  • Zijun Wang
  • Frauke Muecksch

Casellas has published frequently in high-impact venues such as:

  • Nature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • Nature Communications
  • Nature Methods

Best Publications

  • Cohesin Loss Eliminates All Loop Domains

    Suhas S.P. Rao;Suhas S.P. Rao;Su Chen Huang;Brian Glenn St Hilaire;Brian Glenn St Hilaire;Jesse M. Engreitz

  • mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants.

    Zijun Wang;Fabian Schmidt;Yiska Weisblum;Frauke Muecksch

  • c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

    Zuqin Nie;Gangqing Hu;Gang Wei;Kairong Cui

  • AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

    Simone Petersen;Rafael Casellas;Bernardo Reina-San-Martin;Hua Tang Chen

  • MicroRNA-155 Is a Negative Regulator of Activation-Induced Cytidine Deaminase

    Grace Teng;Paul Hakimpour;Pablo Landgraf;Amanda Rice

  • The Energetics and Physiological Impact of Cohesin Extrusion

    Laura Vian;Aleksandra P Pękowska;Suhas S.P. Rao;Suhas S.P. Rao;Kyong-Rim Kieffer-Kwon

  • Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

    Jacqueline H. Barlow;Robert B. Faryabi;Elsa Callén;Nancy Wong

  • Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

    Michela Di Virgilio;Elsa Callen;Arito Yamane;Wenzhu Zhang

  • Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5

    Rushad Pavri;Anna Gazumyan;Anna Gazumyan;Mila Jankovic;Michela Di Virgilio

  • Ku80 is required for immunoglobulin isotype switching.

    Rafael Casellas;Andre Nussenzweig;Robert Wuerffel;Roberta Pelanda;Roberta Pelanda

  • Regulation of MicroRNA Expression and Abundance during Lymphopoiesis

    Stefan Kuchen;Wolfgang Resch;Arito Yamane;Nan Kuo

  • Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes.

    Isaac A. Klein;Wolfgang Resch;Mila Jankovic;Thiago Oliveira;Thiago Oliveira

  • Genome Organization Drives Chromosome Fragility

    Andres Canela;Yaakov Maman;Seolkyoung Jung;Nancy Wong

  • Interactome Maps of Mouse Gene Regulatory Domains Reveal Basic Principles of Transcriptional Regulation

    Kyong-Rim Kieffer-Kwon;Zhonghui Tang;Ewy Mathe;Jason Qian

  • A Genome-wide Map of CTCF Multivalency Redefines the CTCF Code

    Hirotaka Nakahashi;Kyong Rim Kieffer Kwon;Wolfgang Resch;Laura Vian

  • V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses

    Fotini Papavasiliou;Rafael Casellas;Heikyung Suh;Xiao-Feng Qin

  • TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.

    Hayato Takahashi;Tomohiko Kanno;Shingo Nakayamada;Kiyoshi Hirahara

  • The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.

    Michael Kruhlak;Elizabeth E. Crouch;Marika Orlov;Carolina Montaño

  • Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

    Arito Yamane;Wolfgang Resch;Nan Kuo;Stefan Kuchen

  • Erratum: The Energetics and Physiological Impact of Cohesin Extrusion (Cell (2018) 173(5) (1165–1178.e20), (S0092867418304045) (10.1016/j.cell.2018.03.072))

    Laura Vian;Aleksandra Pękowska;Suhas S.P. Rao;Kyong Rim Kieffer-Kwon

Frequent Co-Authors

Michel C. Nussenzweig
Michel C. Nussenzweig Rockefeller University
Thiago Y. Oliveira
Thiago Y. Oliveira Rockefeller University
Davide F. Robbiani
Davide F. Robbiani Universita della Svizzera Italiana
André Nussenzweig
André Nussenzweig National Institutes of Health
David G. Schatz
David G. Schatz Yale University
Frederick W. Alt
Frederick W. Alt Boston Children's Hospital
Markus Müschen
Markus Müschen Yale University
Mila Jankovic
Mila Jankovic Rockefeller University
Hong-Wei Sun
Hong-Wei Sun National Institutes of Health
Anna Gazumyan
Anna Gazumyan Rockefeller University

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Related Online Degrees & Career Pathways

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