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D-Index & Metrics

Molecular Biology

D-Index
70
Citations
17477
World Ranking
1423
National Ranking
723

Overview

David Levens is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on the integration of molecular biology and biochemistry, with a particular emphasis on areas intersecting genomics, RNA biology, and cancer mechanisms.

The scientist's main fields of study include Biochemistry, Genetics, and Molecular Biology, with significant contributions in the following subfields:

  • Molecular Biology
  • Oncology
  • Genetics
  • Cancer Research
  • Biophysics

David Levens has explored a variety of topics related to gene regulation and cancer through experimental and molecular analyses. Their key research topics cover:

  • Genomics and Chromatin Dynamics
  • RNA Research and Splicing
  • RNA modifications and cancer
  • DNA Repair Mechanisms
  • Cancer therapeutics and mechanisms
  • DNA and Nucleic Acid Chemistry
  • Protein Degradation and Inhibitors

Levens has published extensively, with multiple papers in reputable scientific journals. Some recent publications include:

  • "MYC protein stability is negatively regulated by BRD4," 2020, Proceedings of the National Academy of Sciences
  • "MYC: a complex problem," 2022, Trends in Cell Biology
  • "MYC assembles and stimulates topoisomerases 1 and 2 in a "topoisome"," 2021, Molecular Cell
  • "MYC amplifies gene expression through global changes in transcription factor dynamics," 2022, Cell Reports
  • "Dissecting transcriptional amplification by MYC," 2020, eLife

Their frequent collaborators include:

  • Subhendu Das
  • Fedor Kouzine
  • Zuqin Nie
  • Rajeev Jha
  • Laura Baranello

Publication venues where Levens regularly contributes include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • eLife
  • Development
  • Proceedings of the National Academy of Sciences

Best Publications

  • c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

    Zuqin Nie;Gangqing Hu;Gang Wei;Kairong Cui

  • Autopsy pathology in the acquired immune deficiency syndrome.

    C M Reichert;T J O'Leary;D L Levens;C R Simrell

  • Revisiting Global Gene Expression Analysis

    Jakob Lovén;David A. Orlando;Alla A. Sigova;Charles Y. Lin

  • The Energetics and Physiological Impact of Cohesin Extrusion

    Laura Vian;Aleksandra P Pękowska;Suhas S.P. Rao;Suhas S.P. Rao;Kyong-Rim Kieffer-Kwon

  • Heterogeneous nuclear ribonucleoprotein K is a transcription factor.

    E F Michelotti;G A Michelotti;A I Aronsohn;D Levens

  • The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells

    Eva Martinez-Garcia;Relja Popovic;Dong Joon Min;Steve M.M. Sweet

  • A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif.

    Robert Duncan;Leonard Bazar;Greg Michelotti;Takeshi Tomonaga

  • Ribosomal Protein S3: A KH Domain Subunit in NF-κB Complexes that Mediates Selective Gene Regulation

    Fengyi Wan;D. Eric Anderson;Robert A. Barnitz;Andrew Snow

  • Identification of initiation sites for heavy-strand and light-strand transcription in human mitochondrial DNA

    Julio Montoya;Thomas Christianson;David Levens;Murray Rabinowitz

  • H2A.Z Facilitates Access of Active and Repressive Complexes to Chromatin in Embryonic Stem Cell Self-renewal and Differentiation

    Gangqing Hu;Kairong Cui;Daniel Northrup;Chengyu Liu

  • The functional response of upstream DNA to dynamic supercoiling in vivo.

    Fedor Kouzine;Suzanne Sanford;Zichrini Elisha-Feil;David Levens

  • Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples

    Wenfei Jin;Qingsong Tang;Mimi Wan;Kairong Cui

  • Multiple single-stranded cis elements are associated with activated chromatin of the human c-myc gene in vivo.

    G A Michelotti;E F Michelotti;A Pullner;R C Duncan

  • Transcription-dependent dynamic supercoiling is a short-range genomic force

    Fedor Kouzine;Ashutosh Gupta;Ashutosh Gupta;Laura Baranello;Damian Wojtowicz

  • Cooperative Epigenetic Modulation by Cancer Amplicon Genes

    Lixin Rui;N. C.Tolga Emre;Michael J. Kruhlak;Hye Jung Chung

  • Specific binding of heterogeneous ribonucleoprotein particle protein K to the human c-myc promoter, in vitro

    Masato Takimoto;Takeshi Tomonaga;Michael Matunis;Mark Avigan

  • Cellular Nucleic Acid Binding Protein Regulates the CT Element of the Human c- myc Protooncogene

    Emil F. Michelotti;Takeshi Tomonaga;Henry Krutzsch;David Levens

  • RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription.

    Laura Baranello;Damian Wojtowicz;Kairong Cui;Ballachanda N. Devaiah

  • Heterogeneous nuclear ribonucleoprotein K is a DNA-binding transactivator.

    Takeshi Tomonaga;David Levens

  • Erratum: The Energetics and Physiological Impact of Cohesin Extrusion (Cell (2018) 173(5) (1165–1178.e20), (S0092867418304045) (10.1016/j.cell.2018.03.072))

    Laura Vian;Aleksandra Pękowska;Suhas S.P. Rao;Kyong Rim Kieffer-Kwon

Frequent Co-Authors

Teresa M. Przytycka
Teresa M. Przytycka National Institutes of Health
Keji Zhao
Keji Zhao National Institutes of Health
Achim Weber
Achim Weber University of Zurich
Rafael Casellas
Rafael Casellas The University of Texas MD Anderson Cancer Center
Kairong Cui
Kairong Cui National Institutes of Health
Henry C. Krutzsch
Henry C. Krutzsch National Institutes of Health
Ross D. Hannan
Ross D. Hannan Australian National University
Murray Rabinowitz
Murray Rabinowitz University of Chicago
Louis M. Staudt
Louis M. Staudt National Institutes of Health
Peter D. Aplan
Peter D. Aplan National Institutes of Health

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