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D-Index
92
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Overview

Franz M. Matschinsky is affiliated with the University of Pennsylvania in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work spans diverse subfields including molecular biology, surgery, genetics, endocrinology, diabetes, metabolism, and physiology.

Themes central to Matschinsky's research encompass pancreatic function and diabetes, diabetes and associated disorders, diabetes management and research, metabolism related to diabetes and cancer, mitochondrial function and pathology, adipose tissue and metabolism, and diet and metabolism studies.

Several recent publications highlight their research contributions:

  • Ethanol metabolism: The good, the bad, and the ugly, 2020, Medical Hypotheses
  • α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals, 2022, Journal of Clinical Investigation
  • Metabolic Homeostasis in Life as We Know It: Its Origin and Thermodynamic Basis, 2021, Frontiers in Physiology
  • Integration of Eukaryotic Energy Metabolism: The Intramitochondrial and Cytosolic Energy States ([ATP]f/[ADP]f[Pi]), 2022, International Journal of Molecular Sciences
  • Cerebrovascular Blood Flow Design and Regulation; Vulnerability in Aging Brain, 2020, Frontiers in Physiology

Matschinsky often collaborates with several researchers, with frequent co-authors including:

  • David F. Wilson
  • Nicolai M. Doliba
  • Jeffrey Roman
  • Klaus H. Kaestner
  • Andrea V. Rozo

Their work is regularly published in venues such as:

  • Frontiers in Physiology
  • Diabetes
  • Medical Hypotheses
  • Journal of Clinical Investigation
  • International Journal of Molecular Sciences

Best Publications

  • A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm

    Franz M Matschinsky

  • Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion.

    M. Prentki;F. M. Matschinsky

  • Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes.

    Franz M Matschinsky

  • Familial Hyperinsulinism Caused by an Activating Glucokinase Mutation

    B Glaser;P Kesavan;M Heyman;E Davis

  • Pancreatic islet glucose metabolism and regulation of insulin secretion

    Martin D. Meglasson;Franz M. Matschinsky

  • Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy

    Joseph Grimsby;Ramakanth Sarabu;Wendy L. Corbett;Nancy-Ellen Haynes

  • Metabolic Signaling in Fuel-Induced Insulin Secretion

    Marc Prentki;Franz M. Matschinsky;S.R. Murthy Madiraju

  • Neonatal diabetes mellitus due to complete glucokinase deficiency.

    Pål R. Njølstad;Oddmund Søvik;Antonio Cuesta-Muñoz;Lise Bjørkhaug

  • Assessing the potential of glucokinase activators in diabetes therapy

    Franz M. Matschinsky

  • Regulation of Pancreatic β-Cell Glucokinase: From Basics to Therapeutics

    Franz M. Matschinsky

  • Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

    F M Matschinsky;B Glaser;M A Magnuson

  • Pdx1 maintains β-cell identity and function by repressing an α-cell program

    Tao Gao;Brian McKenna;Changhong Li;Maximilian Reichert

  • Structural and Functional Abnormalities in the Islets Isolated From Type 2 Diabetic Subjects

    Shaoping Deng;Marko Vatamaniuk;Xiaolun Huang;Nicolai Doliba

  • Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut.

    T. L. Jetton;Yin Liang;C. C. Pettepher;E. C. Zimmerman

  • A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells.

    B E Corkey;M C Glennon;K S Chen;J T Deeney

  • Glucokinase as pancreatic beta cell glucose sensor and diabetes gene.

    F Matschinsky;Y Liang;P Kesavan;L Wang

  • The Network of Glucokinase-Expressing Cells in Glucose Homeostasis and the Potential of Glucokinase Activators for Diabetes Therapy

    Franz M. Matschinsky;Mark A. Magnuson;Dorothy Zelent;Tom L. Jetton

  • The Central Role of Glucokinase in Glucose Homeostasis: A Perspective 50 Years After Demonstrating the Presence of the Enzyme in Islets of Langerhans.

    Franz M Matschinsky;David F Wilson

  • The MODY1 gene HNF-4α regulates selected genes involved in insulin secretion

    Rana K. Gupta;Marko Z. Vatamaniuk;Catherine S. Lee;Reed C. Flaschen

  • The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy

    Henrik B.T. Christesen;Bendt B. Jacobsen;Stella Odili;Carol Buettger

Frequent Co-Authors

Charles A. Stanley
Charles A. Stanley Children's Hospital of Philadelphia
Mark A. Magnuson
Mark A. Magnuson Vanderbilt University
Ali Naji
Ali Naji University of Pennsylvania
David F. Wilson
David F. Wilson University of Pennsylvania
Klaus H. Kaestner
Klaus H. Kaestner University of Pennsylvania
Marc Prentki
Marc Prentki University of Montreal
Barbara E. Corkey
Barbara E. Corkey Boston University
Itzhak Nissim
Itzhak Nissim Children's Hospital of Philadelphia
Donald A. Godfrey
Donald A. Godfrey University of Toledo
Anna L. Gloyn
Anna L. Gloyn Stanford University

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