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Medicine

D-Index
102
Citations
39417
World Ranking
7640
National Ranking
293

Overview

Marc Prentki is affiliated with the University of Montreal in Canada. Their research broadly covers aspects of medicine, with a particular focus on biochemistry, genetics, and molecular biology. Within these fields, their work intersects with surgery, physiology, molecular biology, epidemiology, and endocrinology, diabetes, and metabolism.

The main topics of Marc Prentki's research include pancreatic function and diabetes, adipose tissue and metabolism, metabolism related to diabetes and cancer, adipokines in inflammation and metabolic diseases, lipid metabolism and biosynthesis, lipoproteins, cardiovascular health, and diabetes treatment and management.

Notable recent papers authored by Marc Prentki encompass a range of studies revolving around metabolic processes and pancreatic function. These include:

  • "Nutrient-Induced Metabolic Stress, Adaptation, Detoxification, and Toxicity in the Pancreatic β-Cell" (2020, Diabetes)

In addition to their own work, Marc Prentki has been associated through collaborative efforts with several frequent co-authors. These researchers and the extent of collaboration include:

  • Marie-Line Peyot (8 collaborations)
  • S.R. Murthy Madiraju (8 collaborations)
  • Roxane Lussier (6 collaborations)
  • Pegah Poursharifi (5 collaborations)
  • Anfal Al-Mass (5 collaborations)

Marc Prentki's publications have appeared in various scientific venues with repeated contributions to some journals. Prominent publication venues in their record include:

  • bioRxiv (Cold Spring Harbor Laboratory) with 3 publications
  • Journal of Diabetes with 3 publications
  • Molecular Metabolism with 2 publications
  • Diabetes with 1 publication
  • Cell Metabolism with 1 publication

Below are examples of recent published papers coauthored or relevant to their fields of focus, demonstrating the thematic concentration on metabolic regulation and pancreatic cell function:

  • "Metabolic cycles and signals for insulin secretion" (2022, Cell Metabolism)
  • "β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel" (2022, eLife)
  • "Adipose ABHD6 regulates tolerance to cold and thermogenic programs" (2020, JCI Insight)
  • "Substantial PCSK9 inactivation in β-cells does not modify glucose homeostasis or insulin secretion in mice" (2021, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids)

Best Publications

  • A genome-wide association study identifies novel risk loci for type 2 diabetes

    Robert Sladek;Ghislain Rocheleau;Johan Rung;Christian Dina

  • Islet β cell failure in type 2 diabetes

    Marc Prentki;Christopher J. Nolan

  • Type 2 diabetes across generations: from pathophysiology to prevention and management

    Christopher J Nolan;Peter Damm;Marc Prentki

  • Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.

    Hans E. Hohmeier;Hindrik Mulder;Guoxun Chen;Rosemarie Henkel-Rieger

  • Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion.

    M. Prentki;F. M. Matschinsky

  • AMPK, insulin resistance, and the metabolic syndrome.

    Neil B. Ruderman;David Carling;Marc Prentki;José M. Cacicedo

  • Saturated Fatty Acids Synergize with Elevated Glucose to Cause Pancreatic β-Cell Death

    Wissal El-Assaad;Jean Buteau;Marie-Line Peyot;Christopher Nolan

  • Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

    Marc Prentki;Barbara E Corkey

  • Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

    J. Buteau;R. Roduit;S. Susini;M. Prentki

  • Malonyl-CoA Signaling, Lipid Partitioning, and Glucolipotoxicity: Role in β-Cell Adaptation and Failure in the Etiology of Diabetes

    Marc Prentki;Erik Joly;Wissal El-Assaad;Raphaël Roduit

  • Metabolic Signaling in Fuel-Induced Insulin Secretion

    Marc Prentki;Franz M. Matschinsky;S.R. Murthy Madiraju

  • Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

    Johan Rung;Stéphane Cauchi;Anders Albrechtsen;Lishuang Shen;Lishuang Shen

  • Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.

    M Prentki;S Vischer;M.C. Glennon;R Regazzi

  • AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

    Neil Ruderman;Marc Prentki

  • Glucagon-Like Peptide 1 Induces Pancreatic β-Cell Proliferation Via Transactivation of the Epidermal Growth Factor Receptor

    Jean Buteau;Sylvain Foisy;Erik Joly;Marc Prentki

  • Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells.

    F Schuit;A De Vos;S Farfari;K Moens

  • Fatty acid signaling in the beta-cell and insulin secretion.

    Christopher J. Nolan;Murthy S.R. Madiraju;Viviane Delghingaro-Augusto;Marie-Line Peyot

  • Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate.

    M Prentki;T J Biden;D Janjic;R F Irvine

  • Glucagon-like peptide-1 prevents beta cell glucolipotoxicity.

    J. Buteau;W. El-Assaad;C. J. Rhodes;L. Rosenberg

  • Coordinate Regulation of Malonyl-CoA Decarboxylase,sn-Glycerol-3-phosphate Acyltransferase, and Acetyl-CoA Carboxylase by AMP-activated Protein Kinase in Rat Tissues in Response to Exercise

    Haejoe Park;Virendar K. Kaushik;Scarlet Constant;Marc Prentki

Frequent Co-Authors

Barbara E. Corkey
Barbara E. Corkey Boston University
Neil B. Ruderman
Neil B. Ruderman Boston University
Franz M. Matschinsky
Franz M. Matschinsky University of Pennsylvania
Philippe Froguel
Philippe Froguel Imperial College London
Oluf Pedersen
Oluf Pedersen University of Copenhagen
Robert Sladek
Robert Sladek McGill University
Christopher J. Rhodes
Christopher J. Rhodes University of Chicago
Claes B. Wollheim
Claes B. Wollheim University of Geneva
Torben Hansen
Torben Hansen University of Copenhagen
Asish K. Saha
Asish K. Saha Boston University

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