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Biology and Biochemistry

D-Index
60
Citations
9720
World Ranking
12206
National Ranking
5213

Overview

Itzhak Nissim is affiliated with the Children's Hospital of Philadelphia in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with notable contributions in subfields such as Cardiology and Cardiovascular Medicine, Molecular Biology, Cancer Research, Pulmonary and Respiratory Medicine, and Genetics.

Their work covers several main topics, including:

  • Cancer, Hypoxia, and Metabolism
  • Metabolism and Genetic Disorders
  • Cardiac Valve Diseases and Treatments
  • Cardiovascular Function and Risk Factors
  • Bone health and treatments
  • Bone health and osteoporosis research
  • Bone Metabolism and Diseases

Among recent publications authored or co-authored by Nissim are:

  • Malic Enzyme Couples Mitochondria with Aerobic Glycolysis in Osteoblasts, 2020, Cell Reports
  • Targeting glutamine metabolism slows soft tissue sarcoma growth, 2020, Nature Communications
  • Glycogen metabolism is dispensable for tumour progression in clear cell renal cell carcinoma, 2021, Nature Metabolism
  • Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma, 2021, Cancer Research
  • Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis, 2020, Cell Metabolism

Frequent co-authors of Nissim include:

  • M. Celeste Simon
  • Pearl Lee
  • Peiwei Huangyang
  • Sanika Khare
  • Jennifer M. Finan

Nissim's research contributions have appeared repeatedly in notable scientific journals such as:

  • Cell Reports
  • Nature Communications
  • Nature Metabolism
  • Cancer Research
  • Cell Metabolism

Best Publications

  • Fructose-1,6-bisphosphatase opposes renal carcinoma progression

    Bo Li;Bo Qiu;David S. M. Lee;David S. M. Lee;Zandra E. Walton

  • mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

    Chunlei Cang;Yandong Zhou;Betsy Navarro;Young Jun Seo

  • Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates

    Joel M. Weinberg;Manjeri A. Venkatachalam;Nancy F. Roeser;Itzhak Nissim

  • Endogenous synthesis of galactose in normal men and patients with hereditary galactosaemia

    G. T. Berry;I. Nissim;Zhiping Lin;A. T. Mazur

  • The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect.

    Marc Yudkoff;Yevgeny Daikhin;Torun Margareta Melø;Ilana Nissim

  • Brain Amino Acid Requirements and Toxicity: The Example of Leucine

    Marc Yudkoff;Yevgeny Daikhin;Ilana Nissim;Oksana Horyn

  • Glutathione turnover in cultured astrocytes: Studies with [15N]glutamate

    Marc Yudkoff;David E Pleasure;Lynn Cregar;Zhi Ping Lin

  • Newer aspects of glutamine/glutamate metabolism: the role of acute pH changes.

    Itzhak Nissim

  • Ketogenic diet, amino acid metabolism, and seizure control.

    Marc Yudkoff;Marc Yudkoff;Yevgeny Daikhin;Ilana Nissim;Adam Lazarow

  • Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase

    Changhong Li;Pan Chen;Andrew Palladino;Srinivas Narayan

  • Response of brain amino acid metabolism to ketosis

    Marc Yudkoff;Yevgeny Daikhin;Ilana Nissim;Oksana Horyn

  • Creatine Synthesis: Hepatic Metabolism of Guanidinoacetate and Creatine in the Rat, in vitro and in vivo

    Robin P. da Silva;Itzhak Nissim;Margaret E. Brosnan;John T. Brosnan

  • Astrocyte leucine metabolism: significance of branched-chain amino acid transamination

    Marc Yudkoff;Yevgeny Daikhin;Lev Grunstein;Ilana Nissim

  • Dietary branched chain amino acids ameliorate injury-induced cognitive impairment

    Jeffrey T. Cole;Christina M. Mitala;Suhali Kundu;Ajay Verma

  • Astrocyte metabolism of [15N]glutamine: implications for the glutamine-glutamate cycle.

    Marc Yudkoff;Itzhak Nissim;David Pleasure

  • Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury.

    Joel M. Weinberg;Manjeri A. Venkatachalam;Nancy F. Roeser;Pothana Saikumar

  • Ketosis and brain handling of glutamate, glutamine, and GABA.

    Marc Yudkoff;Yevgeny Daikhin;Oksana Horyn;Ilana Nissim

  • Interrelationships of leucine and glutamate metabolism in cultured astrocytes.

    M. Yudkoff;Y. Daikhin;Zhi-Ping Lin;I. Nissim

  • Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy.

    Piotr K. Kopinski;Kevin A. Janssen;Patrick M. Schaefer;Sophie Trefely;Sophie Trefely

  • Brain Glutamate Metabolism: Neuronal-Astroglial Relationships

    Marc Yudkoff;Itzhak Nissim;Yevgeny Daikhin;Z.-P. Lin

Frequent Co-Authors

Marc Yudkoff
Marc Yudkoff Children's Hospital of Philadelphia
Stanton Segal
Stanton Segal University of Pennsylvania
David E Pleasure
David E Pleasure University of California, Davis
Maria Erecińska
Maria Erecińska University of Pennsylvania
John T. Brosnan
John T. Brosnan Memorial University of Newfoundland
Charles A. Stanley
Charles A. Stanley Children's Hospital of Philadelphia
Margaret E. Brosnan
Margaret E. Brosnan Memorial University of Newfoundland
Franz M. Matschinsky
Franz M. Matschinsky University of Pennsylvania
M. Celeste Simon
M. Celeste Simon University of Pennsylvania
Brian Keith
Brian Keith University of Pennsylvania

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