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Biology and Biochemistry

D-Index
49
Citations
21168
World Ranking
17818
National Ranking
7293

Overview

Brian Keith is affiliated with the University of Pennsylvania in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work spans numerous subfields, including cancer research, molecular biology, oncology, pulmonary and respiratory medicine, and epidemiology.

The scientist's research is focused primarily on cancer-related topics, particularly in areas involving cancer metabolism, hypoxia, lipid regulation, molecular pathways, and prognosis mechanisms such as ferroptosis. Key thematic areas also include renal cell carcinoma treatment, metabolomics and mass spectrometry studies, and RNA modifications relevant to cancer.

Brian Keith's publication record includes contributions to high-impact journals and prominent publication venues. Some of the recurrent outlets for their research include:

  • Cancer Research
  • Nature Cell Biology
  • Nature Cancer
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Metabolism

Recent notable papers authored or coauthored by Brian Keith cover diverse aspects of cancer biology and metabolism:

  • FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome, 2020, Nature Cell Biology
  • Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer, 2024, Nature Cancer
  • Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis, 2020, Cell Metabolism
  • ASS1 and ASL suppress growth in clear cell renal cell carcinoma via altered nitrogen metabolism, 2021, Cancer & Metabolism
  • Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment, 2024, Cell Reports

Brian Keith collaborates frequently with several researchers, including M. Celeste Simon, Celeste Simon, Michelle Burrows, Clementina Mesaros, and Yanqing Jiang. These collaborations likely support investigations in cancer biology and metabolic regulation.

Best Publications

  • HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

    Brian Keith;Randall S. Johnson;M. Celeste Simon;M. Celeste Simon

  • Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

    Cheng-Jun Hu;Li-Yi Wang;Lewis A. Chodosh;Brian Keith

  • Hypoxia-inducible factors, stem cells, and cancer.

    Brian Keith;M. Celeste Simon;M. Celeste Simon

  • Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

    Omkar U. Kawalekar;Roddy S. O’Connor;Joseph A. Fraietta;Lili Guo

  • The role of oxygen availability in embryonic development and stem cell function.

    M. Celeste Simon;Brian Keith

  • HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth

    Kelly L. Covello;James Kehler;Hongwei Yu;John D. Gordan

  • Hypoxia-induced energy stress regulates mRNA translation and cell growth.

    Liping Liu;Timothy P. Cash;Russell G. Jones;Brian Keith

  • Hypoxia-inducible factor–2 (HIF-2) regulates hepatic erythropoietin in vivo

    Erinn B. Rankin;Mangatt P. Biju;Qingdu Liu;Travis L. Unger

  • Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma.

    Avery D. Posey;Robert D. Schwab;Alina C. Boesteanu;Catharina Steentoft

  • Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation.

    Sonia Guedan;Avery D. Posey;Carolyn Shaw;Anna Wing

  • HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma

    John D. Gordan;Priti Lal;Vijay R. Dondeti;Richard Letrero

  • HIF-2α, but not HIF-1α, promotes iron absorption in mice

    Maria Mastrogiannaki;Pavle Matak;Brian Keith;M. Celeste Simon

  • Acute postnatal ablation of Hif-2α results in anemia

    Michaela Gruber;Cheng-Jun Hu;Randall S. Johnson;Eric J. Brown

  • Fructose-1,6-bisphosphatase opposes renal carcinoma progression

    Bo Li;Bo Qiu;David S. M. Lee;David S. M. Lee;Zandra E. Walton

  • Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

    Hongxia Z. Imtiyaz;Emily P. Williams;Michele M. Hickey;Shetal A. Patel

  • Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18

    Biliang Hu;Jiangtao Ren;Yanping Luo;Brian Keith

  • Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism

    Erinn B. Rankin;Jennifer Rha;Mary A. Selak;Travis L. Unger

  • Oxygen availability and metabolic adaptations

    Michael S. Nakazawa;Brian Keith;M. Celeste Simon

  • Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

    Pinelopi P. Kapitsinou;Qingdu Liu;Travis L. Unger;Jennifer Rha

  • HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma

    Bo Qiu;Daniel Ackerman;Danielle J. Sanchez;Bo Li

Frequent Co-Authors

M. Celeste Simon
M. Celeste Simon University of Pennsylvania
Carl H. June
Carl H. June University of Pennsylvania
Itzhak Nissim
Itzhak Nissim Children's Hospital of Philadelphia
Anthony A. Mancuso
Anthony A. Mancuso University of Florida
J. Alan Diehl
J. Alan Diehl Case Western Reserve University
Randall S. Johnson
Randall S. Johnson University of Cambridge
Ian A. Blair
Ian A. Blair University of Pennsylvania
Katherine L. Nathanson
Katherine L. Nathanson University of Pennsylvania
Craig B. Thompson
Craig B. Thompson Memorial Sloan Kettering Cancer Center
Jeremy N. Rich
Jeremy N. Rich University of Pittsburgh

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