George Simos

Overview

Best Publications

• Nuclear mRNA Export Requires Complex Formation between Mex67p and Mtr2p at the Nuclear Pores

  Helena Santos-Rosa;Horacio Moreno;George Simos;Alexandra Segref

  348
  Citations

• Identification of MAPK Phosphorylation Sites and Their Role in the Localization and Activity of Hypoxia-inducible Factor-1α

  Ilias Mylonis;Georgia Chachami;Martina Samiotaki;George Panayotou

  344
  Citations

• The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases.

  G. Simos;A. Segref;F. Fasiolo;K. Hellmuth

  303
  Citations

• Yeast Los1p Has Properties of an Exportin-Like Nucleocytoplasmic Transport Factor for tRNA

  Klaus Hellmuth;Denise M. Lau;F. Ralf Bischoff;Markus Künzler

  298
  Citations

• An aminoacylation-dependent nuclear tRNA export pathway in yeast

  Helge Grosshans;Ed Hurt;George Simos

  234
  Citations

• Nuclear pore proteins are involved in the biogenesis of functional tRNA.

  G. Simos;H. Tekotte;H. Grosjean;A. Segref

  232
  Citations

• Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p

  Bruno Senger;George Simos;F.Ralf Bischoff;Alexandre Podtelejnikov

  230
  Citations

• A Novel In Vivo Assay Reveals Inhibition of Ribosomal Nuclear Export in Ran-Cycle and Nucleoporin Mutants

  Ed Hurt;Stefan Hannus;Birgit Schmelzl;Denise Lau

  227
  Citations

• Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism

  Ilias Mylonis;George Simos;George Simos;Efrosyni Paraskeva

  218
  Citations

• The lamin B receptor (LBR) provides essential chromatin docking sites at the nuclear envelope.

  A Pyrpasopoulou;J Meier;C Maison;G Simos

  193
  Citations

• Characterization of Yeast Protein Deg1 as Pseudouridine Synthase (Pus3) Catalyzing the Formation of Ψ38 and Ψ39 in tRNA Anticodon Loop

  François Lecointe;George Simos;Anke Sauer;Eduard C. Hurt

  171
  Citations

• Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export.

  Helge Grosshans;Karina Deinert;Ed Hurt;George Simos

  171
  Citations

• A Conserved Domain within Arc1p Delivers tRNA to Aminoacyl-tRNA Synthetases

  George Simos;Anke Sauer;Franco Fasiolo;Eduard C Hurt

  171
  Citations

• Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression

  Ilias Mylonis;Hiroshi Sembongi;Christina Befani;Panagiotis Liakos

  162
  Citations

• Cobalt induces hypoxia-inducible factor-1alpha (HIF-1alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism.

  Anastasia Triantafyllou;Panagiotis Liakos;Andreas Tsakalof;Elena Georgatsou

  159
  Citations

• Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells

  Christina D. Befani;Panagiotis J. Vlachostergios;Eleana Hatzidaki;Anna Patrikidou

  155
  Citations

• The yeast tRNA:pseudouridine synthase Pus1p displays a multisite substrate specificity

  Y Motorin;G Keith;C Simon;D Foiret

  143
  Citations

• Atypical CRM1-dependent Nuclear Export Signal Mediates Regulation of Hypoxia-inducible Factor-1α by MAPK *

  Ilias Mylonis;Georgia Chachami;Efrosyni Paraskeva;George Simos

  131
  Citations

• The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions.

  Ilias Mylonis;Achillia Lakka;Andreas Tsakalof;George Simos

  131
  Citations

• Binding of lamin A to polynucleosomes.

  J Yuan;G Simos;G Blobel;S D Georgatos

  128
  Citations