George Panayotou

Overview

Best Publications

• Phosphoinositide 3-kinases: a conserved family of signal transducers.

  Bart Vanhaesebroeck;Sally J. Leevers;George Panayotou;Michael D. Waterfield

  1356
  Citations

• A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

  Carola Ponzetto;Alberto Bardelli;Alberto Bardelli;Zhu Zhen;Flavio Maina

  1214
  Citations

• Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase.

  Masayuki Otsu;Ian Hiles;Ivan Gout;Michael J. Fry

  922
  Citations

• Phosphatidylinositol 3-kinase : structure and expression of the 110 kd catalytic subunit

  Ian D. Hiles;Masayuki Otsu;Stefano Volinia;Michael J. Fry

  918
  Citations

• Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction.

  M P Wymann;G Bulgarelli-Leva;M J Zvelebil;L Pirola

  889
  Citations

• Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

  K Salim;M J Bottomley;E Querfurth;M J Zvelebil

  742
  Citations

• The GTPase dynamin binds to and is activated by a subset of SH3 domains.

  Ivan Gout;Ritu Dhand;Ian D. Hiles;Michael J. Fry

  695
  Citations

• PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

  R Dhand;I Hiles;G Panayotou;S Roche

  607
  Citations

• PI 3-kinase: structural and functional analysis of intersubunit interactions.

  Ritu Dhand;K. Hara;I. Hiles;B. Bax

  441
  Citations

• Domains of laminin with growth-factor activity

  George Panayotou;Peter End;Monique Aumailley;Rupert Timpl

  421
  Citations

• Characterization of Flavonoid Subgroups and Hydroxy Substitution by HPLC-MS/MS

  Dimitrios Tsimogiannis;Martina Samiotaki;George Panayotou;Vassiliki Oreopoulou

  389
  Citations

• Identification of MAPK Phosphorylation Sites and Their Role in the Localization and Activity of Hypoxia-inducible Factor-1α

  Ilias Mylonis;Georgia Chachami;Martina Samiotaki;George Panayotou

  344
  Citations

• Crystal Structure of a G:T/U Mismatch-Specific DNA Glycosylase: Mismatch Recognition by Complementary-Strand Interactions

  Tracey E Barrett;Renos Savva;George Panayotou;Tom Barlow

  321
  Citations

• The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein

  G Pelicci;Silvia Giordano;Z Zhen;Ae Salcini

  268
  Citations

• The Homeodomain Region of Rag-1 Reveals the Parallel Mechanisms of Bacterial and V(D)J Recombination

  Eugenia Spanopoulou;Florina Zaitseva;Fu-Hou Wang;Sandro Santagata

  267
  Citations

• A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor.

  Carola Ponzetto;Alberto Bardelli;Flavio Maina;Paola Longati

  258
  Citations

• SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors.

  C J McGlade;C Ellis;M Reedijk;D Anderson

  245
  Citations

• Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach.

  G Panayotou;G Gish;P End;O Truong

  228
  Citations

• Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase.

  G.W Booker;A.L Breeze;A.K Downing;G Panayotou

  217
  Citations

• A read-ahead function in archaeal DNA polymerases detects promutagenic template-strand uracil

  Martin A. Greagg;Mark J. Fogg;George Panayotou;Steven J. Evans

  209
  Citations