World's Best Scientists 2026 revealed!

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Immunology

D-Index
70
Citations
16344
World Ranking
2428
National Ranking
93

Overview

Hirokazu Kanegane is affiliated with Tokyo Medical and Dental University in Japan and conducts research primarily in the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Their work focuses on several subfields including Immunology, Genetics, Hematology, Epidemiology, and Infectious Diseases.

Their research addresses topics related to Immunodeficiency and Autoimmune Disorders, Autoimmune and Inflammatory Disorders Research, Immune Cell Function and Interaction, Blood Disorders and Treatments, Chronic Lymphocytic Leukemia Research, Parvovirus B19 Infection Studies, and Cytomegalovirus and Herpesvirus Research.

Kanegane has contributed to multiple recent papers, including:

  • Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency, 2021, Science Immunology
  • A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS, 2021, Nature Immunology
  • APRIL-dependent lifelong plasmacyte maintenance and immunoglobulin production in humans, 2020, Journal of Allergy and Clinical Immunology
  • Detailed analysis of Japanese patients with adenosine deaminase 2 deficiency reveals characteristic elevation of type II interferon signature and STAT1 hyperactivation, 2021, Journal of Allergy and Clinical Immunology
  • Neutralizing Type I Interferon Autoantibodies in Japanese Patients with Severe COVID-19, 2022, Journal of Clinical Immunology

The scientist's frequent coauthors include:

  • Tomohiro Morio (67 coauthored works)
  • Kohsuke Imai (48 coauthored works)
  • Dan Tomomasa (35 coauthored works)
  • Masatoshi Takagi (34 coauthored works)
  • Satoshi Okada (33 coauthored works)

Kanegane's publications often appear in journals such as:

  • Journal of Clinical Immunology (34 publications)
  • Frontiers in Immunology (21 publications)
  • Pediatrics International (14 publications)
  • International Journal of Hematology (10 publications)
  • Clinical Immunology (6 publications)

Best Publications

  • Clinical and virologic characteristics of chronic active Epstein-Barr virus infection

    Hiroshi Kimura;Yo Hoshino;Hirokazu Kanegane;Ikuya Tsuge

  • Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects

    Charlotte Schwab;Annemarie Gabrysch;Peter Olbrich;Virginia Patiño

  • The landscape of somatic mutations in Down syndrome-related myeloid disorders

    Kenichi Yoshida;Tsutomu Toki;Yusuke Okuno;Rika Kanezaki

  • Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP-deficiency) versus type 2 (XLP-2/XIAP-deficiency)

    Jana Pachlopnik Schmid;Jana Pachlopnik Schmid;Danielle Canioni;Despina Moshous;Despina Moshous;Fabien Touzot

  • Proposed guidelines for diagnosing chronic active epstein-barr virus infection

    Motohiko Okano;Keisei Kawa;Hiroshi Kimura;Akihiro Yachie

  • X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management, and outcome of the disease

    Claire Booth;Kimberly C. Gilmour;Paul Veys;Andrew R. Gennery

  • Prognostic Factors for Chronic Active Epstein-Barr Virus Infection

    Hiroshi Kimura;Tsuneo Morishima;Hirokazu Kanegane;Shouichi Ohga

  • Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study

    Federica Barzaghi;Laura Cristina Amaya Hernandez;Benedicte Neven;Silvia Ricci

  • XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation

    Monica Yabal;Nicole Müller;Heiko Adler;Nathalie Knies

  • Genetic analysis of patients with defects in early B-cell development

    Mary Ellen Conley;Mary Ellen Conley;Arnon Broides;Arnon Broides;Vivian Hernandez-Trujillo;Vanessa Howard

  • The Role of Mig, the Monokine Induced by Interferon-γ, and IP-10, the Interferon-γ–Inducible Protein-10, in Tissue Necrosis and Vascular Damage Associated With Epstein-Barr Virus-Positive Lymphoproliferative Disease

    Julie Teruya-Feldstein;Elaine S. Jaffe;Parris R. Burd;Hirokazu Kanegane

  • Production of IL-10 by human natural killer cells stimulated with IL-2 and/or IL-12.

    Priti T. Mehrotra;Raymond P. Donnelly;Susan Wong;Hirokazu Kanegane

  • Contribution of the CXC chemokines IP-10 and Mig to the antitumor effects of IL-12.

    Chiharu Kanegane;Cecilia Sgadari;Hirokazu Kanegane;Julie Teruya-Feldstein

  • Interleukin-15 Promotes Angiogenesisin Vivo

    Anne L. Angiolillo;Hirokazu Kanegane;Cecilia Sgadari;Gregory H. Reaman

  • Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency

    David Boutboul;Hye Sun Kuehn;Zoé Van de Wyngaert;Zoé Van de Wyngaert;Julie E. Niemela

  • Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis

    Toshihiro Nanki;Kazuki Takada;Yukiko Komano;Tomohiro Morio

  • Novel mutations in a Japanese patient with CD19 deficiency

    H Kanegane;K Agematsu;T Futatani;M M Sira

  • Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency.

    Taizo Wada;Hirokazu Kanegane;Kazuhide Ohta;Fumiyo Katoh

  • Role of transforming growth factor-β in breast milk for initiation of IgA production in newborn infants

    Jiro Ogawa;Akiko Sasahara;Taketoshi Yoshida;Mostafa Mohamed Sira

  • Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes

    Rebecca A. Marsh;Kanchan Rao;Prakash Satwani;Kai Lehmberg

  • Primary immunodeficiency diseases

    Takeshi Futatani;Hirokazu Kanegane;Toshio Miyawaki

Frequent Co-Authors

Toshio Miyawaki
Toshio Miyawaki University of Toyama
Kohsuke Imai
Kohsuke Imai Tokyo Medical and Dental University
Tomohiro Morio
Tomohiro Morio Institute of Science Tokyo
Shigeaki Nonoyama
Shigeaki Nonoyama National Defense Medical College
Seiji Kojima
Seiji Kojima Nagoya University
Osamu Ohara
Osamu Ohara Chiba University
Seishi Ogawa
Seishi Ogawa Kyoto University
Akihiro Yachie
Akihiro Yachie Kanazawa University
Satoru Miyano
Satoru Miyano Tokyo Medical and Dental University
Etsuro Ito
Etsuro Ito Hirosaki University

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