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Lennart Hammarström

Lennart Hammarström

D-Index & Metrics

Immunology

D-Index
100
Citations
34150
World Ranking
730
National Ranking
11

Medicine

D-Index
100
Citations
34253
World Ranking
8317
National Ranking
169

Overview

Lennart Hammarström is affiliated with the Karolinska Institute in Sweden and has a substantial body of work primarily focused on medicine, immunology, and molecular biology. Their research spans critical areas such as immunodeficiency, autoimmune disorders, infectious diseases, and the genetic factors influencing immune responses.

The scientist's research has contributed notably to the understanding of COVID-19, particularly the immune mechanisms involved. Some recent papers by their group include:

  • Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths (2021, Science Immunology)
  • X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19 (2021, Science Immunology)
  • Human genetic and immunological determinants of critical COVID-19 pneumonia (2022, Nature)
  • Persistence of SARS-CoV-2-specific B and T cell responses in convalescent COVID-19 patients 6-8 months after the infection (2021, Med)
  • The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies (2022, Proceedings of the National Academy of Sciences)

Frequent co-authors in their research include:

  • Qiang Pan-Hammarström
  • Hassan Abolhassani
  • Harold Marcotte
  • Likun Du
  • Fanglei Zuo

Hammarström's work is often published in notable venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Immunology
  • Journal of Allergy and Clinical Immunology
  • The Journal of Experimental Medicine
  • Frontiers in Immunology

Their research covers several interconnected scientific disciplines. The main fields of study include:

  • Medicine
  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

Within these broader areas, subfields of focus include:

  • Immunology
  • Infectious Diseases
  • Genetics
  • Epidemiology
  • Molecular Biology

The topics of research reflect an emphasis on immune system function and disease:

  • Immunodeficiency and Autoimmune Disorders
  • SARS-CoV-2 and COVID-19 Research
  • Blood disorders and treatments
  • COVID-19 Clinical Research Studies
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Respiratory viral infections research

Best Publications

  • The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

    Vetrie D;Vorechovský I;Sideras P;Sideras P;Holland J

  • Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation.

    Jafar Mahdavi;Berit Sondén;Martina Hurtig;Farzad O. Olfat;Farzad O. Olfat

  • Common variable immunodeficiency disorders: division into distinct clinical phenotypes

    Helen Chapel;Mary Lucas;Martin Lee;Janne Bjorkander

  • International consensus document (icon): common variable immunodeficiency disorders

    Francisco A. Bonilla;Isil Barlan;Helen Chapel;Beatriz Tavares Costa-Carvalho

  • Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans

    U Salzer;H M Chapel;A D B Webster;Q Pan-Hammarström

  • Clinical spectrum of X-linked hyper-IgM syndrome

    Jacov Levy;Teresa Espanol-Boren;Carolin Thomas;Alain Fischer

  • Primary Immunodeficiency Diseases: An Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency

    Waleed Al-Herz;Aziz Bousfiha;Jean-Laurent Casanova;Jean-Laurent Casanova;Helen Chapel

  • Primary immunodeficiency diseases: An update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee

    Raif S. Geha;Luigi D. Notarangelo;Jean Laurent Casanova;Helen Chapel

  • Deleterious Mutations in LRBA Are Associated with a Syndrome of Immune Deficiency and Autoimmunity

    Gabriela Lopez-Herrera;Giacomo Tampella;Qiang Pan-Hammarström;Peer Herholz

  • Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID)

    L Hammarström;I Vorechovsky;D Webster

  • Oral lactobacilli in chronic periodontitis and periodontal health: species composition and antimicrobial activity.

    P. Koll-Klais;R. Mandar;E. Leibur;H. Marcotte

  • B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans

    Klaus Warnatz;Ulrich Salzer;Marta Rizzi;Beate Fischer

  • Assessment of the cPAS-based BGISEQ-500 platform for metagenomic sequencing

    Chao Fang;Huanzi Zhong;Yuxiang Lin;Bing Chen

  • Interleukin 4 induces synthesis of IgE and IgG4 in human B cells.

    Mats Lundgren;Ulla Persson;Ulla Persson;Per Larsson;Carl Magnusson

  • Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome

    Cristina Woellner;E. Michael Gertz;Alejandro A. Schäffer;Macarena Lagos

  • Cancer risk among patients with IgA deficiency or common variable immunodeficiency and their relatives: a combined Danish and Swedish study.

    Lene Mellemkjær;L. Hammarström;V. Andersen;J. Yuen

  • Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

    Alexandra Y. Kreins;Alexandra Y. Kreins;Michael J. Ciancanelli;Satoshi Okada;Xiao Fei Kong

  • Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells.

    C I Smith;B Baskin;P Humire-Greiff;J N Zhou

  • Subcutaneous immunoglobulin replacement in patients with primary antibody deficiencies: safety and costs

    A.Gardulf Rn;L Hammarström;R Gustafson;T Nyström

  • Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency.

    Qiang Pan-Hammarström;Ulrich Salzer;Likun Du;Jan Fredrik Björkander

Frequent Co-Authors

C. I. Edvard Smith
C. I. Edvard Smith Karolinska University Hospital
Qiang Pan-Hammarström
Qiang Pan-Hammarström Karolinska Institute
Asghar Aghamohammadi
Asghar Aghamohammadi Tehran University of Medical Sciences
Nima Rezaei
Nima Rezaei Tehran University of Medical Sciences
Bodo Grimbacher
Bodo Grimbacher University of Freiburg
Alessandro Plebani
Alessandro Plebani University of Brescia
Ning Li
Ning Li China Agricultural University
Helen Chapel
Helen Chapel University of Oxford
Ulrich Salzer
Ulrich Salzer University of Freiburg
Luigi D. Notarangelo
Luigi D. Notarangelo National Institutes of Health

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