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Medicine

D-Index
86
Citations
34366
World Ranking
13944
National Ranking
578

Overview

David Malkin is affiliated with the Hospital for Sick Children in Canada. Their research spans medicine with a significant focus on biochemistry, genetics, and molecular biology. The scientist's work encompasses several subfields, including molecular biology, oncology, cancer research, genetics, and pediatrics, perinatology, and child health.

Malkin's main topics of study reflect this multidisciplinary approach, covering cancer-related molecular pathways, cancer genomics and diagnostics, quality of life for childhood cancer survivors, epigenetics and DNA methylation, genetic factors in colorectal cancer, neuroblastoma research and treatments, and sarcoma diagnosis and treatment.

Several notable recent papers have been authored or co-authored by Malkin, including:

  • Signatures of copy number alterations in human cancer (2022), published in Nature
  • Tumour predisposition and cancer syndromes as models to study gene-environment interactions (2020), published in Nature Reviews. Cancer
  • The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute (2022), published in Cell Death and Differentiation
  • Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency (2022), published in Nature Medicine
  • Analysis of the Li-Fraumeni Spectrum Based on an International Germline TP53 Variant Data Set (2021), published in JAMA Oncology

Malkin frequently collaborates with several researchers, namely Anita Villani, Adam Shlien, Trevor J. Pugh, Christian P. Kratz, and Vallijah Subasri.

The scientist's publications are often found in a range of respected venues, including:

  • Cancer Research
  • Clinical Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • JCO Precision Oncology

Best Publications

  • Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

    David Malkin;Frederick P. Li;Frederick P. Li;Louise C. Strong;Joseph F. Fraumeni

  • Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

    Jeremy Schwartzentruber;Andrey Korshunov;Xiao Yang Liu;David T.W. Jones

  • Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

    Tobias Rausch;David T.W. Jones;Marc Zapatka;Adrian M. Stütz

  • Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency

    Eric Bouffet;Valérie Larouche;Brittany B. Campbell;Daniele Merico

  • Comprehensive Analysis of Hypermutation in Human Cancer

    Brittany B. Campbell;Nicholas Light;David Fabrizio;Matthew Zatzman

  • Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

    S. C. Mack;H. Witt;R. M. Piro;L. Gu

  • Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma

    Nataliya Zhukova;Vijay Ramaswamy;Marc Remke;Elke Pfaff

  • Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.

    David Malkin;Stephen H. Friend;Frederick P. Li;Louise C. Strong

  • Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: 11 year follow-up of a prospective observational study.

    Anita Villani;Ari Shore;Jonathan D. Wasserman;Derek Stephens

  • Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome

    Christian P. Kratz;Maria Isabel Achatz;Laurence Brugieres;Thierry Frebourg

  • Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

    Paul A. Northcott;David J H Shih;Marc Remke;Marc Remke;Yoon-Jae Cho

  • Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study.

    Anita Villani;Uri Tabori;Joshua Schiffman;Adam Shlien

  • Germ-line p53 Mutations Predispose to a Wide Spectrum of Early-onset Cancers

    Kim E. Nichols;David Malkin;Judy E. Garber;Joseph F. Fraumeni

  • Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

    Sebastian M. Waszak;Paul A. Northcott;Paul A. Northcott;Ivo Buchhalter;Giles W. Robinson

  • Cancer Survivorship—Genetic Susceptibility and Second Primary Cancers: Research Strategies and Recommendations

    Lois B. Travis;Charles S. Rabkin;Linda Morris Brown;James M. Allan

  • Childhood cerebellar tumours mirror conserved fetal transcriptional programs

    Maria C. Vladoiu;Ibrahim El-Hamamy;Ibrahim El-Hamamy;Laura K. Donovan;Hamza Farooq

  • Hypoxia Enhances Tumor Stemness by Increasing the Invasive and Tumorigenic Side Population Fraction

    Bikul Das;Rika Tsuchida;David Malkin;Gideon Koren

  • Cytogenetic Prognostication Within Medulloblastoma Subgroups

    David J.H. Shih;Paul A. Northcott;Marc Remke;Andrey Korshunov

  • Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.

    Robert J. Vanner;Marc Remke;Marco Gallo;Hayden J. Selvadurai

  • DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies

    Kris Ann P. Schultz;Gretchen M. Williams;Junne Kamihara;Douglas R. Stewart

Frequent Co-Authors

Uri Tabori
Uri Tabori University of Toronto
Eric Bouffet
Eric Bouffet University of Toronto
Michael D. Taylor
Michael D. Taylor University of Toronto
Cynthia Hawkins
Cynthia Hawkins University of Toronto
Peter B. Dirks
Peter B. Dirks University of Toronto
Vijay Ramaswamy
Vijay Ramaswamy University of Toronto
Nada Jabado
Nada Jabado McGill University
Richard J. Gilbertson
Richard J. Gilbertson University of Cambridge
Stephen H. Friend
Stephen H. Friend Sage Bionetworks
Mark T. Greenberg
Mark T. Greenberg Pennsylvania State University

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