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D-Index & Metrics

Molecular Biology

D-Index
95
Citations
31087
World Ranking
638
National Ranking
348

Overview

Guillermina Lozano is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with significant work in medicine as well. Within these broad fields, the scientist's contributions target subfields such as molecular biology, oncology, cancer research, epidemiology, and pulmonary and respiratory medicine.

The main topics covered in Guillermina Lozano's research include cancer-related molecular pathways, epigenetics and DNA methylation, RNA modifications and cancer, pancreatic and hepatic oncology research, cancer genomics and diagnostics, protein degradation and inhibitors, and ubiquitin and proteasome pathways.

Frequent publication venues for their work include Cancer Research, Cancer Discovery, Proceedings of the National Academy of Sciences, Cell Death and Disease, and Science Advances.

Scientific collaborations have been a consistent part of their work. Frequent co-authors include Shunbin Xiong, Xiaoping Su, Yuan Qi, Gilda P. Chau, and Amanda R. Wasylishen.

Examples of recent papers authored or co-authored by Guillermina Lozano are:

  • Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis, 2021, Cancer Discovery
  • p53 tetramerization: at the center of the dominant-negative effect of mutant p53, 2020, Genes & Development
  • p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo, 2020, Proceedings of the National Academy of Sciences
  • Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo, 2020, Science Advances
  • Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer, 2021, Nature Communications

Best Publications

  • Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

    Roberta Montes de Oca Luna;Daniel S. Wagner;Guillermina Lozano

  • A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.

    Gareth L. Bond;Wenwei Hu;Elisabeth E. Bond;Harlan Robins

  • Gain of Function of a p53 Hot Spot Mutation in a Mouse Model of Li-Fraumeni Syndrome

    Gene A. Lang;Tomoo Iwakuma;Young Ah Suh;Geng Liu

  • Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

    Loretta Raycroft;Hongyun Wu;Guillermina Lozano

  • Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 Degradation

    Roger P. Leng;Yunping Lin;Weili Ma;Hong Wu

  • Rescue of embryonic lethality in Mdm4 -null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

    John Parant;Arturo Chavez-Reyes;Arturo Chavez-Reyes;Natalie A. Little;Wen Yan

  • NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress.

    Hongyun Wu;Guillermina Lozano

  • Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

    Tomer Cooks;Ioannis S. Pateras;Ohad Tarcic;Hilla Solomon

  • p53-independent functions of the p19ARF tumor suppressor

    Jason D. Weber;John R. Jeffers;Jerold E. Rehg;David H. Randle

  • CRITICAL ROLE FOR SER20 OF HUMAN P53 IN THE NEGATIVE REGULATION OF P53 BY MDM2

    Tamar Unger;Tamar Juven-Gershon;Eli Moallem;Michael Berger

  • The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

    Tamara Terzian;Young Ah Suh;Tomoo Iwakuma;Sean M. Post

  • Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

    Jean-Christophe Marine;Sarah Francoz;Marion Maetens;G Wahl

  • Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice.

    Geng Liu;John M Parant;Gene Lang;Patty Chau

  • PML, a growth suppressor disrupted in acute promyelocytic leukemia.

    Zhao Mei Mu;Khew Voon Chin;Jin Hwang Liu;Guillermina Lozano

  • p53 mutation heterogeneity in cancer

    T. Soussi;Guillermina Lozano

  • A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.

    David M Keller;Xiaoya Zeng;Yun Wang;Qing Hong Zhang

  • Mutual Dependence of MDM2 and MDMX in Their Functional Inactivation of p53

    Jijie Gu;Hidehiko Kawai;Linghu Nie;Hiroyuki Kitao

  • Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

    E. M. Alexandrova;A. R. Yallowitz;D. Li;S. Xu

  • A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.

    Javier E. Girardini;Javier E. Girardini;Marco Napoli;Marco Napoli;Silvano Piazza;Alessandra Rustighi;Alessandra Rustighi

  • Synthetic small inhibiting RNAs: Efficient tools to inactivate oncogenic mutations and restore p53 pathways

    Luis Alfonso Martinez;Irina Naguibneva;Heike Lehrmann;Arlette Vervisch

Frequent Co-Authors

Adel K. El-Naggar
Adel K. El-Naggar The University of Texas MD Anderson Cancer Center
Louise C. Strong
Louise C. Strong The University of Texas MD Anderson Cancer Center
Arnold J. Levine
Arnold J. Levine Institute for Advanced Study
Christopher I. Amos
Christopher I. Amos Baylor College of Medicine
Bin Liu
Bin Liu Australian National University
Moshe Oren
Moshe Oren Weizmann Institute of Science
Lawrence A. Donehower
Lawrence A. Donehower Baylor College of Medicine
Varda Rotter
Varda Rotter Weizmann Institute of Science
Björn Olsen
Björn Olsen Harvard University
Ralf Krahe
Ralf Krahe The University of Texas MD Anderson Cancer Center

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