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Genetics

D-Index
52
Citations
9232
World Ranking
3798
National Ranking
1637

Overview

Ralf Krahe is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research spans biochemistry, genetics, and molecular biology, with additional work in neuroscience. The primary focus lies in molecular biology and cellular and molecular neuroscience, with notable contributions in neurology, pathology and forensic medicine, and surgery.

Their investigation covers multiple topics including:

  • Genetic neurodegenerative diseases
  • Mitochondrial function and pathology
  • RNA modifications and cancer
  • RNA research and splicing
  • Parkinson's disease mechanisms and treatments
  • DNA repair mechanisms
  • Fungal and yeast genetics research

Krahe has published extensively in venues such as Human Molecular Genetics, UNC Libraries, PLoS ONE, Journal of Osteoporosis, and Oncology Reports. Among these, Human Molecular Genetics and UNC Libraries are the most frequent publication venues.

The scientist's recent papers include:

  • Longitudinal increases in somatic mosaicism of the expanded CTG repeat in myotonic dystrophy type 1 are associated with variation in age-at-onset, 2020, Human Molecular Genetics
  • Myotonic dystrophy type 1 (DM1) clinical subtypes and CTCF site methylation status flanking the CTG expansion are mutant allele length-dependent, 2021, Human Molecular Genetics
  • Individual-specific levels of CTG•CAG somatic instability are shared across multiple tissues in myotonic dystrophy type 1, 2022, Human Molecular Genetics
  • Towards development of a statistical framework to evaluate myotonic dystrophy type 1 mRNA biomarkers in the context of a clinical trial, 2020, PLoS ONE
  • Methylation of the candidate biomarker TCF21 is very frequent across a spectrum of early-stage nonsmall cell lung cancers, 2020, UNC Libraries

Frequent coauthors of Krahe include Baili Zhang, Darren G. Monckton, Fernando Morales, Melissa Vásquez, and Eyleen Corrales. The collaboration with Fernando Morales is associated with work published in Human Molecular Genetics, reflecting shared research interests in genetic disorders and molecular mechanisms.

Best Publications

  • Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites.

    S. Colella;L. Shen;Keith A Baggerly;J. P.J. Issa

  • The myotonic dystrophies: molecular, clinical, and therapeutic challenges

    Bjarne Udd;Ralf Krahe

  • The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein.

    Renata Kozyraki;John Fyfe;Mette Kristiansen;Christian Gerdes

  • Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics

    Kimmo Virtaneva;Fred A. Wright;Stephan M. Tanner;Bo Yuan

  • Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1.

    Maria Aminoff;Maria Aminoff;Jo Ellen Carter;Robert B. Chadwick;Cheryl Johnson

  • Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia.

    Peter J. Kourlas;Matthew P. Strout;Brian Becknell;Maria Luisa Veronese

  • New nomenclature and DNA testing guidelines for myotonic dystrophy type 1 (DM1)

    T. Ashizawa;I. Gonzales;N. Ohsawa;R. H. Singer

  • POLG mutations in neurodegenerative disorders with ataxia but no muscle involvement

    G Van Goethem;P Luoma;M Rantamaki;A Al Memar

  • Unstable minisatellite expansion causing recessively inherited myoclonus epilepsy, EPM1

    Kimmo Virtaneva;Elena D'Amato;Jinmin Miao;Marjaleena Koskiniemi

  • A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat

    C. A. Boucher;S. K. King;N. Carey;Ralf Krahe

  • Mutations in KERA, encoding keratocan, cause cornea plana.

    Natalia S. Pellegata;Jose L. Dieguez-Lucena;Tarja Joensuu;Stephanie Lau

  • Confirmation of the Type 2 Myotonic Dystrophy (CCTG)n Expansion Mutation in Patients with Proximal Myotonic Myopathy/Proximal Myotonic Dystrophy of Different European Origins: A Single Shared Haplotype Indicates an Ancestral Founder Effect

    Linda L. Bachinski;Bjarne Udd;Giovanni Meola;Valeria Sansone

  • Phenotypical spectrum of DOK7 mutations in congenital myasthenic syndromes

    Juliane S. Müller;Agnes Herczegfalvi;Juan J. Vilchez;Jaume Colomer

  • Effect of Myotonic Dystrophy Trinucleotide Repeat Expansion on DMPK Transcription and Processing

    Ralf Krahe;Tetsuo Ashizawa;Claudia Abbruzzese;Elizabeth Roeder

  • Proximal myotonic dystrophy—a family with autosomal dominant muscular dystrophy, cataracts, hearing loss and hypogonadism: heterogeneity of proximal myotonic syndromes?

    Bjarne Udd;Ralf Krahe;Carina Wallgren-Pettersson;Björn Falck

  • Population frequency of myotonic dystrophy: higher than expected frequency of myotonic dystrophy type 2 (DM2) mutation in Finland

    Tiina Suominen;Linda L Bachinski;Satu Auvinen;Peter Hackman

  • Genome-Wide Hypomethylation in Head and Neck Cancer Is More Pronounced in HPV-Negative Tumors and Is Associated with Genomic Instability

    Kristy L. Richards;Baili Zhang;Keith A. Baggerly;Keith A. Baggerly;Stefano Colella

  • A draft annotation and overview of the human genome

    Fred A Wright;William J Lemon;Wei D Zhao;Russell Sears

  • Pooled analysis of loss of heterozygosity in breast cancer: a genome scan provides comparative evidence for multiple tumor suppressors and identifies novel candidate regions.

    Brian J. Miller;Daolong Wang;Ralf Krahe;Ralf Krahe;Fred A. Wright;Fred A. Wright

  • Splicing factors PTBP1 and PTBP2 promote proliferation and migration of glioma cell lines

    Hannah C. Cheung;Tao Hai;Wen Zhu;Keith A. Baggerly

Frequent Co-Authors

Bjarne Udd
Bjarne Udd University of Helsinki
Keith A. Baggerly
Keith A. Baggerly The University of Texas MD Anderson Cancer Center
Albert de la Chapelle
Albert de la Chapelle The Ohio State University
Fred A. Wright
Fred A. Wright North Carolina State University
Anders Paetau
Anders Paetau University of Helsinki
Benedikt Schoser
Benedikt Schoser Ludwig-Maximilians-Universität München
Darren G. Monckton
Darren G. Monckton University of Glasgow
Gilbert J. Cote
Gilbert J. Cote The University of Texas MD Anderson Cancer Center
Charles A. Thornton
Charles A. Thornton University of Rochester Medical Center
Michael J. Siciliano
Michael J. Siciliano The University of Texas MD Anderson Cancer Center

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