What is he best known for?
The fields of study he is best known for:
Ralf Krahe mainly focuses on Genetics, Myotonic dystrophy, Molecular biology, Gene and Proximal myotonic myopathy.
Ralf Krahe works on Myotonic dystrophy which deals in particular with Myotonia.
His Myotonia research includes themes of Myopathy, Disease, Atrophy, Pathology and Muscular dystrophy.
His studies in Molecular biology integrate themes in fields like Bisulfite sequencing, Myeloid leukemia, DNA repair, RNA-Directed DNA Methylation and Illumina Methylation Assay.
His study in Proximal myotonic myopathy is interdisciplinary in nature, drawing from both Psychiatry, Frontal lobe and Cognition.
His Trinucleotide repeat expansion research includes elements of Untranslated region and Locus.
His most cited work include:
- Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites. (452 citations)
- The myotonic dystrophies: molecular, clinical, and therapeutic challenges (293 citations)
- Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics (289 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Genetics, Myotonic dystrophy, Molecular biology, Gene and Myotonia.
Genetics is closely attributed to Computational biology in his work.
His biological study spans a wide range of topics, including Muscular dystrophy, RNA splicing and Intron.
His Molecular biology research integrates issues from Methylation, DNA methylation, Trinucleotide repeat expansion, Messenger RNA and Chromogenic in situ hybridization.
His biological study deals with issues like Bioinformatics, which deal with fields such as Microarray and Genetic disorder.
Within one scientific family, he focuses on topics pertaining to Pathology under Proximal myotonic myopathy, and may sometimes address concerns connected to Ataxia.
He most often published in these fields:
- Genetics (60.36%)
- Myotonic dystrophy (45.05%)
- Molecular biology (30.63%)
What were the highlights of his more recent work (between 2009-2020)?
- Myotonic dystrophy (45.05%)
- Genetics (60.36%)
- RNA splicing (22.52%)
In recent papers he was focusing on the following fields of study:
Ralf Krahe focuses on Myotonic dystrophy, Genetics, RNA splicing, Molecular biology and Internal medicine.
Ralf Krahe is studying Myotonia, which is a component of Myotonic dystrophy.
His work in Germline mutation and Allele is related to Genetics.
The RNA splicing study combines topics in areas such as Gene expression, Skeletal muscle, Phenotype, Exon and Gene isoform.
The concepts of his Molecular biology study are interwoven with issues in Homeobox, Transcription factor, Cellular differentiation, Signal transduction and Messenger RNA.
His Internal medicine study combines topics in areas such as Endocrinology, Genome-wide association study and Oncology.
Between 2009 and 2020, his most popular works were:
- The myotonic dystrophies: molecular, clinical, and therapeutic challenges (293 citations)
- Population frequency of myotonic dystrophy: higher than expected frequency of myotonic dystrophy type 2 (DM2) mutation in Finland (81 citations)
- Mutant (CCTG)n expansion causes abnormal expression of zinc finger protein 9 (ZNF9) in myotonic dystrophy type 2. (57 citations)
In his most recent research, the most cited papers focused on:
Myotonic dystrophy, Molecular biology, RNA splicing, Gene and Internal medicine are his primary areas of study.
Myotonic dystrophy is a primary field of his research addressed under Genetics.
His work is dedicated to discovering how Molecular biology, Alternative splicing are connected with Intron and Cell biology and other disciplines.
His Internal medicine research is multidisciplinary, relying on both Muscle cell differentiation, Endocrinology, Zinc finger, Regulation of gene expression and RNA-binding protein.
His Myotonia research incorporates elements of RNA, Disease and Genetic testing.
The various areas that Ralf Krahe examines in his Muscular dystrophy study include CLCN1, Mutation frequency, Mutation, Allele frequency and Myotonic Disorder.
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