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Leon H.F. Mullenders

Leon H.F. Mullenders

D-Index & Metrics

Molecular Biology

D-Index
70
Citations
17816
World Ranking
1420
National Ranking
39

Overview

Leon H.F. Mullenders is affiliated with Leiden University in the Netherlands and specializes in biochemistry, genetics, and molecular biology. Their research focuses primarily on molecular biology and employs advanced proteomics and mass spectrometry techniques to investigate cellular processes. Key areas of study include DNA repair mechanisms, the effects of radiation exposure, mitochondrial function and pathology, and physiological and biochemical adaptations.

Their recent scholarly contributions include several publications spanning topics related to cellular responses and molecular signaling pathways. Notable papers authored or co-authored by Mullenders are:

  • "Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action" (2020, Archives of Toxicology)
  • "Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation" (2022, Cells)
  • "Phosphoproteomics Sample Preparation Impacts Biological Interpretation of Phosphorylation Signaling Outcomes" (2021, Cells)
  • "Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses" (2022, DNA Repair)
  • "Retraction Notice to: Cockayne Syndrome A and B Proteins Differentially Regulate Recruitment of Chromatin Remodeling and Repair Factors to Stalled RNA Polymerase II In Vivo" (2021, Molecular Cell)

Mullenders frequently collaborates with other researchers. Their frequent co-authors include Bharath Sampadi, Harry Vrieling, Branislav Mišovic, Jesper V. Olsen, and Hanneke Kool.

Their work is regularly published in specific venues with multiple publications appearing in the journals Cells, DNA Repair, and Molecular Cell. Other publication venues include Archives of Toxicology and the Journal of Radiological Protection.

Research topics covered in Mullenders's work include:

  • Advanced Proteomics Techniques and Applications
  • Mass Spectrometry Techniques and Applications
  • DNA Repair Mechanisms
  • Effects of Radiation Exposure
  • Mitochondrial Function and Pathology
  • Molecular Biology Techniques and Applications
  • Physiological and biochemical adaptations

The subfields of study connected to their research reflect a broad intersection of molecular biology with other disciplines such as spectroscopy and medical imaging, specifically radiology, nuclear medicine, and imaging.

  • Molecular Biology
  • Spectroscopy
  • Radiology, Nuclear Medicine and Imaging
  • Ecology
  • Pulmonary and Respiratory Medicine

Best Publications

  • Sequential Assembly of the Nucleotide Excision Repair Factors In Vivo

    Marcel Volker;Martijn J Moné;Parimal Karmakar;Anneke van Hoffen

  • The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA.

    J. Venema;L. H. F. Mullenders;A. T. Natarajan;A. A. Van Zeeland

  • UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer

    Frank R de Gruijl;Henk J van Kranen;Leon H.F Mullenders

  • Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo.

    Maria Fousteri;Wim Vermeulen;Albert A. van Zeeland;Leon H.F. Mullenders

  • Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells

    Tomoo Ogi;Siripan Limsirichaikul;Siripan Limsirichaikul;René M. Overmeer;Marcel Volker

  • Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes.

    J. Venema;A. Van Hoffen;V. Karcagi;A. T. Natarajan

  • Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells.

    van Hoffen A;Natarajan At;Mayne Lv;van Zeeland Aa

  • Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cells

    Patricia Kannouche;Bernard C. Broughton;Marcel Volker;Fumio Hanaoka

  • Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner

    Jill Moser;Hanneke Kool;Ioannis Giakzidis;Keith Caldecott

  • Transcription-coupled repair removes both cyclobutane pyrimidine dimers and 6-4 photoproducts with equal efficiency and in a sequential way from transcribed DNA in xeroderma pigmentosum group C fibroblasts.

    A. Van Hoffen;J. Venema;R. Meschini;A. A. Van Zeeland

  • The residual repair capacity of xeroderma pigmentosum complementation group C fibroblasts is highly specific for transcriptionally active DNA

    Jaap Venema;Anneke van Hoffen;A.T. Natarajan;Albert A. van Zeeland

  • Heterochromatin protein 1 is recruited to various types of DNA damage

    Martijn S. Luijsterburg;Martijn S. Luijsterburg;Christoffel Dinant;Hannes Lans;Jan Stap

  • PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1

    Alex Pines;Mischa G. Vrouwe;Jurgen A. Marteijn;Dimitris Typas

  • Rapid Switching of TFIIH between RNA Polymerase I and II Transcription and DNA Repair In Vivo

    Deborah Hoogstraten;Alex L Nigg;Helen Heath;Leon H.F Mullenders

  • Differential effects of toxic metal compounds on the activities of Fpg and XPA, two zinc finger proteins involved in DNA repair.

    Monika Asmuss;Leon H.F. Mullenders;André Eker;Andrea Hartwig

  • Assessing cancer risks of low-dose radiation

    Leon Mullenders;Mike Atkinson;Herwig Paretzke;Laure Sabatier

  • High-resolution in situ hybridization using DNA halo preparations

    J. Wiegant;W. Kalle;L. Mullenders;S. Brookes

  • The core spliceosome as target and effector of non-canonical ATM signalling

    Maria Tresini;Daniël O. Warmerdam;Petros Kolovos;Loes Snijder

  • Interaction of arsenic(III) with nucleotide excision repair in UV-irradiated human fibroblasts.

    A. Hartwig;U. D. Gröblinghoff;D. Beyersmann;A. T. Natarajan

  • The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells

    Joanne Gw Nijhof;Kristin M Braun;Adam Giangreco;Carina van Pelt

Frequent Co-Authors

Adayapalam T. Natarajan
Adayapalam T. Natarajan Leiden University
Harry Vrieling
Harry Vrieling Leiden University Medical Center
Paul H.M. Lohman
Paul H.M. Lohman Leiden University Medical Center
Firouz Darroudi
Firouz Darroudi Leiden University Medical Center
Harry van Steeg
Harry van Steeg Centre for Health Protection
Alan R. Lehmann
Alan R. Lehmann University of Sussex
Gijsbertus T. J. van der Horst
Gijsbertus T. J. van der Horst Erasmus University Rotterdam
Nicolaas G. J. Jaspers
Nicolaas G. J. Jaspers Erasmus University Rotterdam
Wim Vermeulen
Wim Vermeulen Erasmus University Rotterdam
Errol C. Friedberg
Errol C. Friedberg The University of Texas Southwestern Medical Center

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