Leon H.F. Mullenders mainly focuses on Molecular biology, DNA repair, Xeroderma pigmentosum, Nucleotide excision repair and DNA. The study incorporates disciplines such as Transcription factor II B, General transcription factor, RNA polymerase II, Computational biology and Transcription factor II D in addition to Molecular biology. His DNA damage research extends to DNA repair, which is thematically connected.
In his study, which falls under the umbrella issue of Xeroderma pigmentosum, DNA polymerase eta, Proliferating cell nuclear antigen, Cancer research and Carcinogenesis is strongly linked to Mutation. Leon H.F. Mullenders focuses mostly in the field of Nucleotide excision repair, narrowing it down to topics relating to Carcinogen and, in certain cases, Medical physics and Intensive care medicine. Pyrimidine dimer and DNA glycosylase are the core of his DNA study.
His primary scientific interests are in Molecular biology, DNA repair, Nucleotide excision repair, DNA and DNA damage. His Molecular biology research includes themes of Mutation, Transcription, Mutagenesis, Gene and Pyrimidine dimer. His DNA repair study incorporates themes from Oligonucleotide and Cell biology.
His research in Nucleotide excision repair intersects with topics in Chromatin, Cancer research, Xeroderma pigmentosum and Carcinogen. The Xeroderma pigmentosum study which covers Carcinogenesis that intersects with Apoptosis. His study in the fields of Nuclear matrix under the domain of DNA overlaps with other disciplines such as Nucleoid.
His scientific interests lie mostly in Cell biology, Nucleotide excision repair, DNA repair, DNA damage and Molecular biology. Leon H.F. Mullenders is interested in Cockayne syndrome, which is a branch of Nucleotide excision repair. In his research, Gene mutation is intimately related to Epidermis, which falls under the overarching field of DNA repair.
His DNA damage study is related to the wider topic of DNA. His DNA research includes elements of Mutagenesis and Interphase. The Molecular biology study combines topics in areas such as Global genome nucleotide-excision repair, Polymerase, Apoptosis, Chromatin and Comet assay.
Leon H.F. Mullenders mostly deals with DNA damage, Cell biology, Molecular biology, Nucleotide excision repair and DNA. His studies deal with areas such as HMG-box, DDB1, DNA ligase and DNA repair as well as DNA damage. His DNA repair study is concerned with the field of Gene as a whole.
His Molecular biology research integrates issues from Signal transduction, Premature chromosome condensation and Mutagenesis. His Nucleotide excision repair research incorporates themes from Replication protein A, Cancer research, Xeroderma pigmentosum, Carcinogenesis and Ubiquitin ligase. His work on Pyrimidine dimer and Comet assay is typically connected to Nucleoid as part of general DNA study, connecting several disciplines of science.
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The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA.
J. Venema;L. H. F. Mullenders;A. T. Natarajan;A. A. Van Zeeland.
Proceedings of the National Academy of Sciences of the United States of America (1990)
UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer
Frank R de Gruijl;Henk J van Kranen;Leon H.F Mullenders.
Journal of Photochemistry and Photobiology B-biology (2001)
Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes.
J. Venema;A. Van Hoffen;V. Karcagi;A. T. Natarajan.
Molecular and Cellular Biology (1991)
Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells.
van Hoffen A;Natarajan At;Mayne Lv;van Zeeland Aa.
Nucleic Acids Research (1993)
Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cells
Patricia Kannouche;Bernard C. Broughton;Marcel Volker;Fumio Hanaoka.
Genes & Development (2001)
Transcription-coupled repair removes both cyclobutane pyrimidine dimers and 6-4 photoproducts with equal efficiency and in a sequential way from transcribed DNA in xeroderma pigmentosum group C fibroblasts.
A. Van Hoffen;J. Venema;R. Meschini;A. A. Van Zeeland.
The EMBO Journal (1995)
The residual repair capacity of xeroderma pigmentosum complementation group C fibroblasts is highly specific for transcriptionally active DNA
Jaap Venema;Anneke van Hoffen;A.T. Natarajan;Albert A. van Zeeland.
Nucleic Acids Research (1990)
Rapid Switching of TFIIH between RNA Polymerase I and II Transcription and DNA Repair In Vivo
Deborah Hoogstraten;Alex L Nigg;Helen Heath;Leon H.F Mullenders.
Molecular Cell (2002)
Differential effects of toxic metal compounds on the activities of Fpg and XPA, two zinc finger proteins involved in DNA repair.
Monika Asmuss;Leon H.F. Mullenders;André Eker;Andrea Hartwig.
High-resolution in situ hybridization using DNA halo preparations
J. Wiegant;W. Kalle;L. Mullenders;S. Brookes.
Human Molecular Genetics (1992)
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