H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 119 Citations 55,808 285 World Ranking 205 National Ranking 7

Research.com Recognitions

Awards & Achievements

2000 - Royal Netherlands Academy of Arts and Sciences

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Genetics

Jan H.J. Hoeijmakers mainly focuses on DNA repair, Nucleotide excision repair, Molecular biology, Genetics and DNA damage. His DNA repair research integrates issues from Cancer research and Helicase. The Cancer research study combines topics in areas such as Senescence and Progeria.

His work deals with themes such as Replication protein A and Xeroderma pigmentosum, which intersect with Nucleotide excision repair. The various areas that Jan H.J. Hoeijmakers examines in his Molecular biology study include Mutant, General transcription factor, DNA-binding protein, Cell biology and Histone. His DNA damage study combines topics in areas such as Mutation, Proliferating cell nuclear antigen, Homologous recombination and Ageing.

His most cited work include:

  • Genome maintenance mechanisms for preventing cancer (3232 citations)
  • DNA Damage, Aging, and Cancer (1361 citations)
  • Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. (1093 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include DNA repair, Nucleotide excision repair, Genetics, Molecular biology and DNA damage. His biological study spans a wide range of topics, including Cancer research and Cell biology. The concepts of his Cell biology study are interwoven with issues in Chromatin, Cell cycle and Replication protein A.

His Nucleotide excision repair research incorporates elements of Transcription and Helicase. His study focuses on the intersection of Molecular biology and fields such as Pyrimidine dimer with connections in the field of Photolyase. His DNA damage research includes elements of Internal medicine, Senescence and Endocrinology.

He most often published in these fields:

  • DNA repair (55.45%)
  • Nucleotide excision repair (43.83%)
  • Genetics (36.80%)

What were the highlights of his more recent work (between 2013-2021)?

  • DNA damage (31.48%)
  • DNA repair (55.45%)
  • Internal medicine (11.14%)

In recent papers he was focusing on the following fields of study:

Jan H.J. Hoeijmakers mainly investigates DNA damage, DNA repair, Internal medicine, Genetics and Cell biology. His DNA damage research is included under the broader classification of DNA. His DNA repair research is multidisciplinary, relying on both Molecular biology, Cancer research and Genome instability.

His Internal medicine study also includes fields such as

  • Endocrinology which is related to area like Senescence, Ageing and Transcriptome,
  • Oncology which is related to area like Cancer, Cancer treatment and Chemotherapy. His Cell biology study integrates concerns from other disciplines, such as Cell, Transcription and Deficient mouse. His Nucleotide excision repair study combines topics from a wide range of disciplines, such as Point mutation and Somatic cell.

Between 2013 and 2021, his most popular works were:

  • An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA (732 citations)
  • Understanding nucleotide excision repair and its roles in cancer and ageing (575 citations)
  • Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging (527 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Mutation

Jan H.J. Hoeijmakers spends much of his time researching DNA damage, DNA repair, Cell biology, Genetics and Senescence. Jan H.J. Hoeijmakers works in the field of DNA damage, namely Nucleotide excision repair. His research integrates issues of Cytotoxic T cell, RNA polymerase II and DNA replication in his study of Nucleotide excision repair.

His research on DNA repair also deals with topics like

  • Genome instability which is related to area like Gene,
  • Molecular biology and related Cancer. His Genetics study frequently links to adjacent areas such as Human studies. His work deals with themes such as Genotoxic Stress, Endocrinology and Cancer research, which intersect with Senescence.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Genome maintenance mechanisms for preventing cancer

Jan H. J. Hoeijmakers.
Nature (2001)

5670 Citations

DNA Damage, Aging, and Cancer

Jan H. J. Hoeijmakers.
The New England Journal of Medicine (2009)

2137 Citations

Chromosomal stability and the DNA double-stranded break connection.

Dik C. van Gent;Jan H. J. Hoeijmakers;Roland Kanaar.
Nature Reviews Genetics (2001)

1607 Citations

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms.

Gijsbertus T.J. Van Der Horst;Manja Muijtjens;Kumiko Kobayashi;Riya Takano.
Nature (1999)

1457 Citations

Molecular mechanism of nucleotide excision repair

W. L. De Laat;N. G. J. Jaspers;J. H. J. Hoeijmakers.
Genes & Development (1999)

1342 Citations

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

Derrick J. Rossi;David Bryder;David Bryder;Jun Seita;Andre Nussenzweig.
Nature (2007)

1072 Citations

Xeroderma Pigmentosum Group C Protein Complex Is the Initiator of Global Genome Nucleotide Excision Repair

Kaoru Sugasawa;Jessica M.Y Ng;Chikahide Masutani;Shigenori Iwai.
Molecular Cell (1998)

1059 Citations

DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor

Laurent Schaeffer;Richard Roy;Sandrine Humbert;Vincent Moncollin.
Science (1993)

942 Citations

Sequential Assembly of the Nucleotide Excision Repair Factors In Vivo

Marcel Volker;Martijn J Moné;Parimal Karmakar;Anneke van Hoffen.
Molecular Cell (2001)

937 Citations

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Marco Demaria;Naoko Ohtani;Sameh A Youssef;Francis Rodier.
Developmental Cell (2014)

910 Citations

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