1991 - Member of Academia Europaea
Member of the European Molecular Biology Organization (EMBO)
His primary scientific interests are in DNA repair, Molecular biology, Genetics, Nucleotide excision repair and Xeroderma pigmentosum. He interconnects Complementation and Ubiquitin in the investigation of issues within DNA repair. The concepts of his Molecular biology study are interwoven with issues in Homologous recombination, Carcinogenesis, Biochemistry, Chromosome and Gene product.
His work on Gene, Genetic linkage, Phenotype and Chromosomal translocation as part of general Genetics study is frequently linked to Transcription, therefore connecting diverse disciplines of science. His Nucleotide excision repair research is multidisciplinary, relying on both Pyrimidine dimer, RNA polymerase II and Helicase. Xeroderma pigmentosum is the subject of his research, which falls under DNA damage.
His primary areas of investigation include Molecular biology, Genetics, DNA repair, Xeroderma pigmentosum and Gene. Dirk Bootsma has included themes like DNA, Chinese hamster, Nucleotide excision repair and Chromosome, Chromosome 22 in his Molecular biology study. His research in Chromosome tackles topics such as Chromosomal translocation which are related to areas like Chromosome 9.
As part of his studies on Genetics, Dirk Bootsma often connects relevant areas like Cancer research. His DNA repair research incorporates themes from Mutation and DNA synthesis. His biological study spans a wide range of topics, including Complementation and Complementation group.
Dirk Bootsma focuses on Nucleotide excision repair, DNA repair, Genetics, Molecular biology and Xeroderma pigmentosum. His Nucleotide excision repair study integrates concerns from other disciplines, such as Carcinogenesis, Cell biology and Pyrimidine dimer. His DNA repair course of study focuses on RNA polymerase II and Transcription factor.
His research links Enzyme with Genetics. His studies in Molecular biology integrate themes in fields like Homologous recombination, General transcription factor and DNA replication. His Xeroderma pigmentosum research includes elements of Chiasma and DNA repair synthesis.
Dirk Bootsma mainly focuses on Molecular biology, Nucleotide excision repair, DNA damage, Genetics and Homologous recombination. In his work, Transcription factor II H, ERCC6 and Cockayne syndrome is strongly intertwined with Carcinogenesis, which is a subfield of Molecular biology. His Nucleotide excision repair study is concerned with the field of DNA repair as a whole.
His DNA repair research is multidisciplinary, incorporating elements of RNA polymerase II and General transcription factor. His DNA damage research includes themes of Gene targeting and Saccharomyces cerevisiae. His study in the field of Photolyase also crosses realms of ARNTL Transcription Factors, Oscillating gene, Translation and Cryptochrome-1.
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A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
Annelies de Klein;Ad Geurts van Kessel;Gerard Grosveld;Claus R. Bartram.
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms.
Gijsbertus T.J. Van Der Horst;Manja Muijtjens;Kumiko Kobayashi;Riya Takano.
Xeroderma Pigmentosum Group C Protein Complex Is the Initiator of Global Genome Nucleotide Excision Repair
Kaoru Sugasawa;Jessica M.Y Ng;Chikahide Masutani;Shigenori Iwai.
Molecular Cell (1998)
Translocation of c- abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia
Claus R. Bartram;Annelies de Klein;Anne Hagemeijer;Ton van Agthoven.
Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation.
A. R. Lehmann;S. Kirk-Bell;C. F. Arlett;M. C. Paterson.
Proceedings of the National Academy of Sciences of the United States of America (1975)
ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes.
Christine Troelstra;Alain van Gool;Jan de Wit;Wim Vermeulen.
Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.
Jeroen Essers;Rudolf W Hendriks;Sigrid M.A Swagemakers;Christine Troelstra.
Inactivation of the HR6B Ubiquitin-Conjugating DNA Repair Enzyme in Mice Causes Male Sterility Associated with Chromatin Modification
H.P Roest;J van Klaveren;J de Wit;C.G van Gurp.
A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome.
Geert Weeda;Reinier C.A. van Ham;Wim Vermeulen;Dirk Bootsma.
Xeroderma pigmentosum: biochemical and genetic characteristics.
James E. Cleaver;D. Bootsma.
Annual Review of Genetics (1975)
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