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Genetics and Molecular Biology
France
2024

D-Index & Metrics

Molecular Biology

D-Index
86
Citations
22882
World Ranking
829
National Ranking
23

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in France Leader Award

Overview

Alain Sarasin is affiliated with the Institut Gustave Roussy in France and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research primarily focuses on molecular biology with significant work in cancer research, immunology, pathology, forensic medicine, and oncology.

The main scientific themes in Sarasin's body of work include DNA repair mechanisms, cancer genomics and diagnostics, genetic factors in colorectal cancer, melanin and skin pigmentation, cancer-related molecular pathways, chromosomal and genetic variations, and melanoma and MAPK pathways.

Among their recent publications are:

  • Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients (2023, Nature Communications)
  • Increased risk of internal tumors in DNA repair-deficient xeroderma pigmentosum patients: analysis of four international cohorts (2022, Orphanet Journal of Rare Diseases)
  • XPC deficiency increases risk of hematologic malignancies through mutator phenotype and characteristic mutational signature (2020, Nature Communications)
  • NK Cell and Fibroblast-Mediated Regulation of Skin Squamous Cell Carcinoma Invasion by CLEC2A Is Compromised in Xeroderma Pigmentosum (2020, Journal of Investigative Dermatology)
  • Defective transcription of ATF3 responsive genes, a marker for Cockayne Syndrome (2020, Scientific Reports)

Sarasin's collaborative network includes frequent co-authors such as Andrey A. Yurchenko, Carlos Frederico Martins Menck, Sergey I. Nikolaev, Ligia Pereira Castro, and Ismaël Padioleau.

The scientist's work has been published frequently in venues including bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Scientific Reports, Frontiers in Immunology, and Orphanet Journal of Rare Diseases.

Best Publications

  • Gene Expression Profiling of Primary Cutaneous Melanoma and Clinical Outcome

    Véronique Winnepenninckx;Vladimir Lazar;Stefan Michiels;Philippe Dessen

  • High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation

    A Bounacer;R Wicker;B Caillou;A F Cailleux;A F Cailleux

  • Transcription-coupled Nucleotide Excision Repair as a Determinant of Cisplatin Sensitivity of Human Cells

    Takahisa Furuta;Takahiro Ueda;Gregory Aune;Alain Sarasin

  • Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome.

    Florence Le Page;Ely E. Kwoh;Anna Avrutskaya;Alain Gentil

  • Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients

    Nicolas Dumaz;Christiane Drougard;Alain Sarasin;Leela Daya-Grosjean

  • RETRACTED: Transcription-Coupled Repair of 8-oxoGuanine

    Florence Le Page;Ely E. Kwoh;Anna Avrutskaya;Alain Gentil

  • TP53 mutations in human skin cancers

    Giuseppina Giglia-Mari;Alain Sarasin

  • Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene

    Elaine M. Taylor;Bernard C. Broughton;Elena Botta;Miria Stefanini

  • Incidence of DNA repair deficiency disorders in western Europe: Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy.

    Wim J. Kleijer;Vincent Laugel;Mark Berneburg;Tiziana Nardo

  • UV Irradiation Triggers Ubiquitin-Dependent Degradation of p21WAF1 to Promote DNA Repair

    Mourad Bendjennat;Jérôme Boulaire;Thomas Jascur;Howard Brickner

  • ERCC2/XPD gene polymorphisms and cancer risk.

    Simone Benhamou;Alain Sarasin

  • High expression of DNA repair pathways is associated with metastasis in melanoma patients.

    A Kauffmann;F Rosselli;V Lazar;V Winnepenninckx

  • The molecular pathways of ultraviolet-induced carcinogenesis.

    Alain Sarasin

  • Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes

    Francoise Bernerd;Alain Sarasin;Thierry Magnaldo

  • XPD Mutations Prevent TFIIH-Dependent Transactivation by Nuclear Receptors and Phosphorylation of RARα

    Anne Keriel;Anne Stary;Alain Sarasin;Cécile Rochette-Egly

  • ERCC2 /XPD Gene Polymorphisms and Lung Cancer: A HuGE Review

    Simone Benhamou;Alain Sarasin

  • DNA repair: from molecular mechanism to human disease.

    Errol C. Friedberg;Andres Aguilera;Martin Gellert;Phillip C. Hanawalt

  • BRCA1 and BRCA2 Are Necessary for the Transcription-Coupled Repair of the Oxidative 8-Oxoguanine Lesion in Human Cells

    Florence Le Page;Voahangy Randrianarison;Didier Marot;Jeannine Cabannes

  • Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome.

    V. Laugel;C. Dalloz;M. Durand;F. Sauvanaud

  • The specificity of p53 mutation spectra in sunlight induced human cancers.

    Leela Daya-Grosjean;Nicolas Dumaz;Alain Sarasin

Frequent Co-Authors

Carlos Frederico Martins Menck
Carlos Frederico Martins Menck Universidade de São Paulo
Alan R. Lehmann
Alan R. Lehmann University of Sussex
Marie-Françoise Avril
Marie-Françoise Avril Université Paris Cité
Miria Stefanini
Miria Stefanini National Research Council (CNR)
Stefan Michiels
Stefan Michiels University of Paris-Saclay
Caroline Robert
Caroline Robert University of Paris-Saclay
Philippe Dessen
Philippe Dessen Institut Gustave Roussy
Philip C. Hanawalt
Philip C. Hanawalt Stanford University
Jan H.J. Hoeijmakers
Jan H.J. Hoeijmakers Erasmus University Rotterdam

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