His scientific interests lie mostly in DNA repair, Genetics, Nucleotide excision repair, Xeroderma pigmentosum and DNA damage. His work in Ataxia-telangiectasia, Transcription Factor TFIIH, Gene and Fanconi anemia is related to Genetics. His Ataxia-telangiectasia study combines topics in areas such as Positional cloning and Ataxia Telangiectasia Mutated Proteins.
The Nucleotide excision repair study combines topics in areas such as Replication protein A and Molecular biology. His Xeroderma pigmentosum research incorporates elements of Cancer research and ERCC4. His DNA damage study integrates concerns from other disciplines, such as Mutation, CDC25A and Homologous recombination.
The scientist’s investigation covers issues in Genetics, DNA repair, Molecular biology, Nucleotide excision repair and Xeroderma pigmentosum. His study in Trichothiodystrophy, Gene, Ataxia-telangiectasia, Mutation and Transcription factor II H is done as part of Genetics. His work focuses on many connections between DNA repair and other disciplines, such as DNA damage, that overlap with his field of interest in Homologous recombination.
The study incorporates disciplines such as Chinese hamster, DNA, DNA replication, DNA synthesis and Complementation in addition to Molecular biology. His Nucleotide excision repair research includes elements of Replication protein A, DNA-binding protein and Cell biology. His research in Xeroderma pigmentosum tackles topics such as Cancer research which are related to areas like Progeria.
His primary areas of study are DNA repair, Xeroderma pigmentosum, Genetics, Nucleotide excision repair and Molecular biology. Nicolaas G. J. Jaspers interconnects Cell cycle checkpoint, DNA damage and Transcription factor II E in the investigation of issues within DNA repair. His work is dedicated to discovering how Xeroderma pigmentosum, Dermatology are connected with Pathology and Disease and other disciplines.
His study in Nucleotide excision repair is interdisciplinary in nature, drawing from both Phenotype, Cancer research, Proliferating cell nuclear antigen and DNA polymerase. The various areas that Nicolaas G. J. Jaspers examines in his Molecular biology study include ERCC1, Mutation, Postreplication repair, Fetus and DNA replication. The concepts of his Microcephaly study are interwoven with issues in Ataxia-telangiectasia and ERCC6.
His primary scientific interests are in DNA repair, Xeroderma pigmentosum, Genetics, Nucleotide excision repair and Dermatology. His study looks at the relationship between DNA repair and fields such as DNA damage, as well as how they intersect with chemical problems. His work deals with themes such as Cerebral atrophy, Disease and Immunosuppression, which intersect with Xeroderma pigmentosum.
His Nucleotide excision repair research is multidisciplinary, incorporating elements of Mutation and Point mutation. Nicolaas G. J. Jaspers has researched Mutation in several fields, including Molecular biology, Mutant, ERCC4 and ERCC1. His Dermatology study also includes
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A SINGLE ATAXIA TELANGIECTASIA GENE WITH A PRODUCT SIMILAR TO PI-3 KINASE
Kinneret Savitsky;Anat Bar-Shira;Shlomit Gilad;Galit Rotman.
Molecular mechanism of nucleotide excision repair
W. L. De Laat;N. G. J. Jaspers;J. H. J. Hoeijmakers.
Genes & Development (1999)
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
Laura J. Niedernhofer;George A. Garinis;Anja Raams;Astrid S. Lalai.
Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease
Anneke M. Sijbers;Wouter L. De Laat;Rafael R. Ariza;Maureen Biggerstaff.
The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks
Laura J. Niedernhofer;Hanny Odijk;Magda Budzowska;Ellen van Drunen.
Molecular and Cellular Biology (2004)
DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair
Wouter L. de Laat;Esther Appeldoorn;Kaoru Sugasawa;Eric Weterings.
Genes & Development (1998)
SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype
Chantal Stoepker;Karolina Hain;Beatrice Schuster;Yvonne Hilhorst-Hofstee.
Nature Genetics (2011)
Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells
Tomoo Ogi;Siripan Limsirichaikul;Siripan Limsirichaikul;René M. Overmeer;Marcel Volker.
Molecular Cell (2010)
A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A
Giuseppina Giglia-Mari;Frederic Coin;Jeffrey A Ranish;Deborah Hoogstraten.
Nature Genetics (2004)
Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene
Elaine M. Taylor;Bernard C. Broughton;Elena Botta;Miria Stefanini.
Proceedings of the National Academy of Sciences of the United States of America (1997)
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