Colin F. Arlett

What is he best known for?

The fields of study he is best known for:

• Gene
• DNA
• Cancer

His primary scientific interests are in Molecular biology, Genetics, Xeroderma pigmentosum, Nucleotide excision repair and Ataxia-telangiectasia. His research in Molecular biology intersects with topics in Cell culture, Cell, Radiosensitivity, DNA and Cell killing. His work in the fields of Microsatellite and Str profiling overlaps with other areas such as Profiling and Reference standards.

His Xeroderma pigmentosum research is multidisciplinary, relying on both Cerebral atrophy, Disease and Immunosuppression. While the research belongs to areas of Nucleotide excision repair, Colin F. Arlett spends his time largely on the problem of Complementation, intersecting his research to questions surrounding DNA damage and Postreplication repair. His Ataxia-telangiectasia study integrates concerns from other disciplines, such as Positional cloning, Ionizing radiation, Cancer research and Pathology.

His most cited work include:

• A SINGLE ATAXIA TELANGIECTASIA GENE WITH A PRODUCT SIMILAR TO PI-3 KINASE (2378 citations)
• Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity (863 citations)
• Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation. (539 citations)

What are the main themes of his work throughout his whole career to date?

Colin F. Arlett mainly investigates Molecular biology, Genetics, Xeroderma pigmentosum, DNA and Cell culture. Colin F. Arlett combines subjects such as Radiosensitivity, DNA damage, Mutation, Mutant and Fibroblast with his study of Molecular biology. The various areas that Colin F. Arlett examines in his Radiosensitivity study include Ataxia-telangiectasia, Cancer research, Nuclear medicine and Pathology.

His Ataxia-telangiectasia research integrates issues from Heterozygote advantage, Radiation sensitivity and DNA synthesis. Colin F. Arlett connects Genetics with Ultraviolet light in his study. His studies deal with areas such as Nucleotide excision repair and Immunology as well as Xeroderma pigmentosum.

He most often published in these fields:

• Molecular biology (46.75%)
• Genetics (31.17%)
• Xeroderma pigmentosum (25.97%)

What were the highlights of his more recent work (between 1998-2012)?

• Xeroderma pigmentosum (25.97%)
• Molecular biology (46.75%)
• DNA repair (17.53%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Xeroderma pigmentosum, Molecular biology, DNA repair, DNA and Genetics. The concepts of his Xeroderma pigmentosum study are interwoven with issues in Radiation therapy and Pigmentation disorder, Pathology. His Molecular biology study incorporates themes from Pyrimidine dimer, Apoptosis, Keratinocyte and DNA repair protein XRCC4.

Colin F. Arlett does research in DNA repair, focusing on Nucleotide excision repair specifically. His work in Nucleotide excision repair covers topics such as Comet assay which are related to areas like Radiation sensitivity and Cisplatin. His Photodermatosis research also works with subjects such as

• Radiosensitivity and HaCaT most often made with reference to Cancer research,
• Ionizing radiation and related Fibroblast.

Between 1998 and 2012, his most popular works were:

• Short tandem repeat profiling provides an international reference standard for human cell lines (348 citations)
• Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient (329 citations)
• Neurological symptoms and natural course of xeroderma pigmentosum. (98 citations)

In his most recent research, the most cited papers focused on:

• Gene
• DNA
• Cancer

Genetics, Xeroderma pigmentosum, DNA, Cancer research and DNA repair are his primary areas of study. His work on Genetics deals in particular with Short Tandem Repeat Profile, Human cell, DNA profiling, Str profiling and Microsatellite. His research integrates issues of Nucleotide excision repair and Skin cancer in his study of Xeroderma pigmentosum.

His work carried out in the field of DNA brings together such families of science as Mutation and Molecular biology. Colin F. Arlett interconnects Apoptosis and HaCaT, In vitro in the investigation of issues within Cancer research. As part of one scientific family, Colin F. Arlett deals mainly with the area of DNA repair, narrowing it down to issues related to the Chronic toxicity, and often Pathology.