World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
96
Citations
32876
World Ranking
613
National Ranking
337

Overview

John B. Little was affiliated with Harvard University in the United States. Their research mainly focused on mathematics, contributing extensively to the field with a total of 13 publications. Within mathematics, they specialized notably in geometry and topology, accounting for 7 of their works, and also contributed to areas such as statistical and nonlinear physics, theoretical computer science, and oncology.

Their research topics covered a variety of themes, which included:

  • Nonlinear Waves and Solitons
  • Mathematics and Applications
  • History and Theory of Mathematics
  • Cancer-related Molecular Pathways
  • Nonlinear Photonic Systems
  • Advanced Differential Equations and Dynamical Systems
  • Polynomial and algebraic computation

John B. Little's recent publications demonstrated a diversity in their academic interests. Some of their works included:

  • Reading to learn? The co-development of mathematics and reading during primary school (2022) published in Child Development
  • MDMX phosphorylation-dependent p53 downregulation contributes to an immunosuppressive tumor microenvironment (2020) published in Journal of Molecular Cell Biology
  • The MDM2/MDMX/p53 axis in the adaptive stress response (2020) published in Translational Cancer Research
  • Book Review: Computational Mathematics with SageMath (2020) published in Bulletin of the American Mathematical Society
  • The eclectic content and sources of Clavius's Geometria Practica (2022) published in Archive for History of Exact Sciences

The venues where John B. Little frequently published included:

  • arXiv (Cornell University)
  • Australasian Psychiatry
  • Child Development
  • Journal of Molecular Cell Biology
  • Translational Cancer Research

Throughout their career, they collaborated most often with a range of coauthors, including Donal O'Shea, David A. Cox, Zhi-Min Yuan, Türkü Özlüm Çelik, and Matthew Higgins.

In addition to journal publications, John B. Little contributed to book literature, notably publishing through Springer Science+Business Media. Among these was the book titled Ideals, Varieties, and Algorithms, projected for publication in 2025.

Best Publications

  • Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know

    David J. Brenner;Richard Doll;Dudley T. Goodhead;Eric J. Hall

  • Induction of sister chromatid exchanges by extremely low doses of alpha-particles.

    Hatsumi Nagasawa;John B. Little

  • Significance of the relationship between lung recoil and maximum expiratory flow.

    Jere Mead;James M. Turner;Peter T. Macklem;John B. Little

  • Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from α-particle irradiated to nonirradiated cells

    Edouard I. Azzam;Sonia M. de Toledo;John B. Little

  • Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles.

    Edouard I. Azzam;Sonia M. de Toledo;Tamara Gooding;John B. Little

  • Oxidative Metabolism Modulates Signal Transduction and Micronucleus Formation in Bystander Cells from α-Particle-irradiated Normal Human Fibroblast Cultures

    Edouard I. Azzam;Sonia M. de Toledo;Sonia M. de Toledo;Douglas R. Spitz;John B. Little

  • Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect.

    Edouard I Azzam;Edouard I Azzam;Sonia M de Toledo;John B Little

  • Plateau-phase cultures of mammalian cells: an in vitro model for human cancer.

    Hahn Gm;Little Jb

  • Cancer Survivorship—Genetic Susceptibility and Second Primary Cancers: Research Strategies and Recommendations

    Lois B. Travis;Charles S. Rabkin;Linda Morris Brown;James M. Allan

  • Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect.

    Hatsumi Nagasawa;John B. Little

  • Mutation spectrum of the p53 gene in bone and soft tissue sarcomas.

    Junya Toguchida;Toshikazu Yamaguchi;Bruce Ritchie;Roberta L. Beauchamp

  • Prevalence and Spectrum of Germline Mutations of the p53 Gene among Patients with Sarcoma

    Junya Toguchida;Toshikazu Yamaguchi;Siri H. Dayton;Roberta L. Beaughamp

  • Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling.

    David W. Yandell;Tracey A. Campbell;Siri H. Dayton;Robert Petersen

  • Relationship between x-ray exposure and malignant transformation in C3H 10T1/2 cells.

    Ann R. Kennedy;Maurice Fox;Gary Murphy;John B. Little

  • Ku70: A Candidate Tumor Suppressor Gene for Murine T Cell Lymphoma

    Gloria C. Li;Honghai Ouyang;Xiaoling Li;Hatsumi Nagasawa

  • Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect

    Chuan-Yuan Li;Laurent Suardet;John B. Little

  • X-radiation-induced transformation in a c3h mouse embryo-derived cell line.

    Margaret Terzaghi;John B. Little

  • Cell transformation by chemical agents--a review and analysis of the literature. A report of the U.S. Environmental Protection Agency Gene-Tox Program.

    Charles Heidelberger;Aaron E Freeman;Roman J Pienta;Andrew Sivak

  • X-Ray Sensitivity of Fifty-three Human Diploid Fibroblast Cell Strains from Patients with Characterized Genetic Disorders

    Ralph R. Weichselbaum;John Nove;John B. Little

  • Radiation-induced genomic instability: delayed mutagenic and cytogenetic effects of X rays and alpha particles.

    John B. Little;Hatsumi Nagasawa;Tracy Pfenning;Helen Vetrovs

Frequent Co-Authors

Hatsumi Nagasawa
Hatsumi Nagasawa Colorado State University
Ralph R. Weichselbaum
Ralph R. Weichselbaum University of Chicago
Chuan-Yuan Li
Chuan-Yuan Li Duke University
Zhi-Min Yuan
Zhi-Min Yuan Harvard University
David W. Yandell
David W. Yandell Harvard University
Karl T. Kelsey
Karl T. Kelsey Brown University
David J. Chen
David J. Chen The University of Texas Southwestern Medical Center
Albert J. Fornace
Albert J. Fornace Georgetown University
Peter C. Keng
Peter C. Keng University of Rochester
Cameron J. Koch
Cameron J. Koch University of Pennsylvania

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Best Scientists Citing John B. Little