2026 Michael B. Kastan: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Molecular Biology	96	601	537	331	293	203	69443

Research.com Recognitions

2016 - Member of the National Academy of Sciences
2014 - Fellow of the American Academy of Arts and Sciences
2013 - Fellow of the American Association for the Advancement of Science (AAAS)
2009 - Member of the National Academy of Medicine (NAM)
Member of the Association of American Physicians
Member of the Association of American Physicians

Overview

Michael B. Kastan is affiliated with Duke University in the United States. Their research predominantly spans the fields of Biochemistry, Genetics and Molecular Biology, with notable contributions to Medicine as well. Their subfields of study include Molecular Biology, Oncology, Cell Biology, Cancer Research, and Pathology and Forensic Medicine.

The scientist's main areas of work focus on several topics, including:

DNA Repair Mechanisms
Cancer-related Molecular Pathways
Mitochondrial Function and Pathology
RNA Research and Splicing
Carcinogens and Genotoxicity Assessment
PARP inhibition in cancer therapy
Cancer therapeutics and mechanisms

Recent publications by Michael B. Kastan include:

Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia, 2020, iScience
A Novel Dual ATM/DNA-PK Inhibitor, XRD-0394, Potently Radiosensitizes and Potentiates PARP and Topoisomerase I Inhibitors, 2024, Molecular Cancer Therapeutics
DNA-Damage-Induced Alternative Splicing of p53, 2021, Cancers
ATM Regulation of the Cohesin Complex Is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double-Strand Breaks, 2022, Molecular Cancer Research
Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway, 2023, Radiation Research

Kastan's frequent co-authors include:

John E. Niederhuber
Jamés O. Armitage
James H. Doroshow
Joel E. Tepper
Chun-Hsiang Lai

The scientist has published books with Elsevier BV, notably contributing to "Abeloff's Clinical Oncology" in 2020.

Michael B. Kastan's work has appeared in multiple publication venues including:

iScience
Molecular Cancer Therapeutics
Cancers
Molecular Cancer Research
Radiation Research

Throughout their career, Kastan has been recognized with several memberships and fellowships:

Member of the National Academy of Sciences (2016)
Fellow of the American Academy of Arts and Sciences (2014)
Fellow of the American Association for the Advancement of Science (AAAS) (2013)
Member of the National Academy of Medicine (NAM) (2009)
Member of the Association of American Physicians

Best Publications

Participation of p53 Protein in the Cellular Response to DNA Damage

Michael B. Kastan;Onyinye Onyekwere;David Sidransky;Bert Vogelstein

5269
Citations
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Christopher J. Bakkenist;Michael B. Kastan

4316
Citations
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

Michael B. Kastan;Qimin Zhan;Wafik S. El-Deiry

4121
Citations
Cell cycle control and cancer

Leland H. Hartwell;Michael B. Kastan

3987
Citations
Cell-cycle checkpoints and cancer

Michael B. Kastan;Jiri Bartek

3559
Citations
Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

Steven J. Kuerbitz;Beverly S. Plunkett;William V. Walsh;Michael B. Kastan

2680
Citations
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Christine E. Canman;Dae Sik Lim;Karlene A. Cimprich;Yoichi Taya

2672
Citations
The complexity of p53 modulation: emerging patterns from divergent signals

Amato J. Giaccia;Michael B. Kastan

1995
Citations
Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

Emily H.-Y. Cheng;Emily H.-Y. Cheng;David G. Kirsch;David G. Kirsch;Rollie J. Clem;Rollie J. Clem;Rajani Ravi;Rajani Ravi

1603
Citations
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.

ML Smith;IT Chen;Q Zhan;I Bae

1270
Citations
DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

William G. Nelson;Michael B. Kastan

1168
Citations
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

Md. Hasan Zaki;Kelli L. Boyd;Peter Vogel;Michael B. Kastan

1098
Citations
DNA DAMAGE INDUCES PHOSPHORYLATION OF THE AMINO TERMINUS OF P53

Janet D. Siliciano;Christine E. Canman;Yoichi Taya;Kazuyasu Sakaguchi

1079
Citations
Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

Seong Tae Kim;Dae Sik Lim;Christine E. Canman;Michael B. Kastan

1070
Citations
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

Dae-Sik Lim;Seong-Tae Kim;Bo Xu;Richard S. Maser

1016
Citations
The many substrates and functions of ATM.

Michael B. Kastan;Dae-sik Lim

1001
Citations
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.

Ruth Maya;Moshe Balass;Seong-Tae Kim;Dganit Shkedy

932
Citations
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Angela Alexander;Sheng Li Cai;Jinhee Kim;Adrian Nanez

821
Citations
Regulation of p53 Translation and Induction after DNA Damage by Ribosomal Protein L26 and Nucleolin

Masatoshi Takagi;Michael J. Absalon;Kevin G. McLure;Michael B. Kastan

765
Citations
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

Simon Bekker-Jensen;Claudia Lukas;Risa Kitagawa;Fredrik Melander

741
Citations

Frequent Co-Authors

Dae-Sik Lim Korea Advanced Institute of Science and Technology

Curt I. Civin University of Maryland, Baltimore

Albert J. Fornace Georgetown University

Cheryl L. Walker Baylor College of Medicine

Yosef Shiloh Tel Aviv University

Tej K. Pandita Houston Methodist

Qimin Zhan Peking University Stomatological Hospital

Michael W. Lieberman Baylor College of Medicine

Mustafa Sahin Boston Children's Hospital

John L. Cleveland Moffitt Cancer Center

External Links

Personal website of Michael B. Kastan

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