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Molecular Biology

D-Index
55
Citations
10184
World Ranking
2280
National Ranking
53

Overview

Harry Vrieling is affiliated with Leiden University Medical Center in the Netherlands and conducts research primarily in the fields of biochemistry, genetics, and molecular biology, with significant contributions also in medicine. Their work spans multiple subfields including molecular biology, genetics, oncology, spectroscopy, and plant science.

The researcher focuses on several main topics, including:

  • PARP inhibition in cancer therapy
  • DNA repair mechanisms
  • BRCA gene mutations in cancer
  • Genomics and rare diseases
  • RNA and protein synthesis mechanisms
  • RNA research and splicing
  • Advanced proteomics techniques and applications

Recent publications provide insight into the scope of their research. Notable papers include:

  • "The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods" (2020) in Archives of Toxicology
  • "The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas" (2020) in Cancers
  • "Alternative mRNA splicing can attenuate the pathogenicity of presumed loss-of-function variants in BRCA2" (2020) in Genetics in Medicine
  • "RAD51 as a functional biomarker for homologous recombination deficiency in cancer: a promising addition to the HRD toolbox?" (2021) in Expert Review of Molecular Diagnostics
  • "The RAD51-FFPE Test; Calibration of a Functional Homologous Recombination Deficiency Test on Diagnostic Endometrial and Ovarian Tumor Blocks" (2021) in Cancers

Vrieling collaborates frequently with a group of coauthors, including:

  • Maaike P.G. Vreeswijk
  • Lise M. van Wijk
  • Sylvia Vermeulen
  • Claire J.H. Kramer
  • Natalja T. ter Haar

The scientist's research output is often published in specialized journals such as:

  • Cancers
  • Archives of Toxicology
  • Genetics in Medicine
  • Cancer Research
  • Cells

Best Publications

  • An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

    Oded Kopper;Chris J de Witte;Kadi Lõhmussaar;Jose Espejo Valle-Inclan

  • Neomorphic agouti mutations in obese yellow mice

    David M. J. Duhl;Harry Vrieling;Kimberly A. Miller;George L. Wolff

  • Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.

    M. W. Miller;D. M. J. Duhl;H. Vrieling;S. P. Cordes

  • Wnt but Not BMP Signaling Is Involved in the Inhibitory Action of Sclerostin on BMP-Stimulated Bone Formation

    Rutger L. van Bezooijen;J. Peter Svensson;J. Peter Svensson;Daniël Eefting;Annemieke Visser

  • Adverse outcome pathways: opportunities, limitations and open questions.

    Marcel Leist;Ahmed Ghallab;Ahmed Ghallab;Rabea Graepel;Rosemarie Marchan

  • A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein

    Jessica M.Y. Ng;Wim Vermeulen;Gijsbertus T.J. van der Horst;Steven Bergink

  • PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1

    Alex Pines;Mischa G. Vrouwe;Jurgen A. Marteijn;Dimitris Typas

  • Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene.

    Harry Vrieling;David M. J. Duhl;Sarah E. Millar;Kimberly A. Miller

  • The UV-damaged DNA binding protein mediates efficient targeting of the nucleotide excision repair complex to UV-induced photo lesions

    Jill Moser;Marcel Volker;Hanneke Kool;Sergei Alekseev

  • DNA strand specificity for UV-induced mutations in mammalian cells.

    H Vrieling;M L Van Rooijen;N A Groen;M Z Zdzienicka

  • UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II

    Davy A. P. Rockx;Rebecca Mason;Rebecca Mason;Anneke van Hoffen;Michelle Craig Barton

  • Functional Ex Vivo Assay to Select Homologous Recombination–Deficient Breast Tumors for PARP Inhibitor Treatment

    Kishan A.T. Naipal;Nicole S. Verkaik;Najim Ameziane;Carolien H.M. van Deurzen

  • Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas.

    Marthe M de Jonge;Aurelie Auguste;Lise M van Wijk;Philip C Schouten

  • Analysis of gene expression using gene sets discriminates cancer patients with and without late radiation toxicity.

    J. Peter Svensson;Lukas J. A Stalpers;Rebecca E. E. Esveldt–van Lange;Nicolaas A. P Franken

  • Developmental Defects and Male Sterility in Mice Lacking the Ubiquitin-Like DNA Repair Gene mHR23B

    Jessica M. Y. Ng;Harry Vrieling;Kaoru Sugasawa;Marja P. Ooms

  • Pleiotropic effects of the mouse lethal yellow (Ay) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs.

    D. M. J. Duhl;M. E. Stevens;H. Vrieling;P. J. Saxon

  • Mutations induced by X-rays at the HPRT locus in cultured Chinese hamster cells are mostly large deletions.

    H. Vrieling;J.W.I.M. Simons;F. Arwert;A.T. Natarajan

  • The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage.

    Petra P. H. Van Sloun;Jacob G. Jansen;Geert Weeda;Leon H. F. Mullenders

  • Analysis of repair of cyclobutane pyrimidine dimers and pyrimidine 6-4 pyrimidone photoproducts in transcriptionally active and inactive genes in Chinese hamster cells.

    M. P. J. Vreeswijk;A. Van Hoffen;B. E. Westland;H. Vrieling

  • The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals.

    Giel Hendriks;Mirna Atallah;Bruno Morolli;Fabienne Calléja

Frequent Co-Authors

Leon H.F. Mullenders
Leon H.F. Mullenders Leiden University
Paul H.M. Lohman
Paul H.M. Lohman Leiden University Medical Center
Bob van de Water
Bob van de Water Leiden University
Adayapalam T. Natarajan
Adayapalam T. Natarajan Leiden University
Jan H.J. Hoeijmakers
Jan H.J. Hoeijmakers Erasmus University Rotterdam
Erik H.J. Danen
Erik H.J. Danen Leiden University
Gijsbertus T. J. van der Horst
Gijsbertus T. J. van der Horst Erasmus University Rotterdam
Gregory S. Barsh
Gregory S. Barsh Stanford University
Hanneke C. Kluin-Nelemans
Hanneke C. Kluin-Nelemans University Medical Center Groningen
Jesper V. Olsen
Jesper V. Olsen University of Copenhagen

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