World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
15370
World Ranking
9619
National Ranking
4248

Overview

William N. Zagotta is affiliated with the University of Washington in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology with a focus on Molecular Biology, Biophysics, Cellular and Molecular Neuroscience, Spectroscopy, and Materials Chemistry.

Their work addresses several specific scientific topics, including:

  • Electron Spin Resonance Studies
  • Ion channel regulation and function
  • Mass Spectrometry Techniques and Applications
  • Photosynthetic Processes and Mechanisms
  • Neuroscience and Neuropharmacology Research
  • Neuroscience and Neural Engineering
  • Lanthanide and Transition Metal Complexes

Zagotta has an extensive publication record with frequent contributions to several scientific journals and preprint servers. The most common venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysical Journal
  • eLife
  • Proceedings of the National Academy of Sciences
  • Journal of the American Chemical Society

Recent papers authored or co-authored by Zagotta illustrate ongoing interests in ion channels and spectroscopic techniques. Notable publications include:

  • "Allosteric conformational change of a cyclic nucleotide-gated ion channel revealed by DEER spectroscopy," 2020, Proceedings of the National Academy of Sciences
  • "Ultrafast Bioorthogonal Spin-Labeling and Distance Measurements in Mammalian Cells Using Small, Genetically Encoded Tetrazine Amino Acids," 2023, Journal of the American Chemical Society
  • "Genetic encoding of a highly photostable, long lifetime fluorescent amino acid for imaging in mammalian cells," 2021, Chemical Science
  • "An improved fluorescent noncanonical amino acid for measuring conformational distributions using time-resolved transition metal ion FRET," 2021, eLife
  • "Electromechanical coupling mechanism for activation and inactivation of an HCN channel," 2021, Nature Communications

The scientist frequently collaborates with other researchers. Some of their common co-authors are:

  • Sharona E. Gordon
  • Eric G.B. Evans
  • Pierce Eggan
  • Stefan Stoll
  • E. James Petersson

Best Publications

  • Biophysical and molecular mechanisms of shaker potassium channel inactivation

    Toshinori Hoshi;William N. Zagotta;Richard W. Aldrich

  • Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB

    William N. Zagotta;Toshinori Hoshi;Richard W. Aldrich

  • Two types of inactivation in Shaker K+ channels: Effects of alterations in the carboxy-terminal region

    Toshinori Hoshi;William N. Zagotta;Richard W. Aldrich

  • Structural basis for modulation and agonist specificity of HCN pacemaker channels

    William N. Zagotta;Nelson B. Olivier;Kevin D. Black;Edgar C. Young

  • Shaker potassium channel gating. III: Evaluation of kinetic models for activation

    William N. Zagotta;Toshinori Hoshi;Toshinori Hoshi;Richard W Aldrich

  • CNG AND HCN CHANNELS: Two Peas, One Pod

    Kimberley B. Craven;William N. Zagotta

  • Voltage-dependent gating of Shaker A-type potassium channels in Drosophila muscle.

    W N Zagotta;R W Aldrich

  • Crystal structure of the plant dual-affinity nitrate transporter NRT1.1

    Ji Sun;John R. Bankston;Jian Payandeh;Thomas R. Hinds

  • Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit.

    Jie Zheng;Matthew C. Trudeau;William N. Zagotta

  • Cyclic Nucleotide-Gated Ion Channels

    Kimberly Matulef;William N. Zagotta

  • Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels

    Michael D. Varnum;Kevin D. Black;William N. Zagotta

  • Shaker potassium channel gating. I: Transitions near the open state.

    Toshinori Hoshi;William N. Zagotta;William N. Zagotta;Richard W. Aldrich

  • Conformational Changes in S6 Coupled to the Opening of Cyclic Nucleotide-Gated Channels

    Galen E Flynn;William N Zagotta

  • Stoichiometry and Assembly of Olfactory Cyclic Nucleotide-Gated Channels

    Jie Zheng;William N. Zagotta

  • Interdomain Interactions Underlying Activation of Cyclic Nucleotide-Gated Channels

    Michael D. Varnum;William N. Zagotta

  • Single-channel and genetic analyses reveal two distinct A-type potassium channels in Drosophila

    Charles K. Solc;William N. Zagotta;Richard W. Aldrich

  • Mapping the structure and conformational movements of proteins with transition metal ion FRET

    Justin W Taraska;Michael C Puljung;Nelson B Olivier;Galen E Flynn

  • COOPERATIVE SUBUNIT INTERACTIONS IN C-TYPE INACTIVATION OF K CHANNELS

    E. M. Ogielska;W. N. Zagotta;T. Hoshi;S. H. Heinemann

  • Salt Bridges and Gating in the COOH-terminal Region of HCN2 and CNGA1 Channels

    Kimberley B. Craven;William N. Zagotta

  • Gating of single Shaker potassium channels in Drosophila muscle and in Xenopus oocytes injected with Shaker mRNA

    W. N. Zagotta;T. Hoshi;R. W. Aldrich

Frequent Co-Authors

Frank DiMaio
Frank DiMaio University of Washington
David Veesler
David Veesler University of Washington
Dane M. Chetkovich
Dane M. Chetkovich Vanderbilt University Medical Center
Jun Li
Jun Li University of Oklahoma Health Sciences Center
Henry A. Lester
Henry A. Lester California Institute of Technology
Rachel E. Klevit
Rachel E. Klevit University of Washington
William A. Catterall
William A. Catterall University of Washington
Lance Stewart
Lance Stewart University of Washington
Félix A. Rey
Félix A. Rey Institut Pasteur
Eric Gouaux
Eric Gouaux Oregon Health & Science University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing William N. Zagotta

Trending Scientists