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D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
15243
World Ranking
15407
National Ranking
6431

Overview

Lance Stewart is affiliated with the University of Washington in the United States. Their research primarily spans the fields of Materials Science and Biochemistry, Genetics and Molecular Biology, with specific focus on subfields including Materials Chemistry, Molecular Biology, Infectious Diseases, Radiology, Nuclear Medicine and Imaging, and Immunology.

Their research covers a range of topics, notably:

  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Monoclonal and Polyclonal Antibodies Research
  • SARS-CoV-2 and COVID-19 Research
  • Protein Structure and Dynamics
  • RNA and Protein Synthesis Mechanisms
  • Chemical Synthesis and Analysis

Stewart has contributed to multiple scientific publications, including these recent papers:

  • "De novo design of picomolar SARS-CoV-2 miniprotein inhibitors," 2020, Science
  • "Design of protein-binding proteins from the target structure alone," 2022, Nature
  • "Improving de novo protein binder design with deep learning," 2023, Nature Communications
  • "Quadrivalent influenza nanoparticle vaccines induce broad protection," 2021, Nature
  • "De novo design of modular and tunable protein biosensors," 2021, Nature

Frequent co-authors collaborating with Stewart include:

  • David Baker
  • Asim K. Bera
  • Xinting Li
  • Stephen Rettie
  • Parisa Hosseinzadeh

Their work has appeared regularly in various scientific venues, with multiple publications in:

  • The Cambridge Structural Database
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Nature Communications
  • Cell

Best Publications

  • Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

    Matthew R. Redinbo;Lance Stewart;Peter Kuhn;James J. Champoux

  • The mechanism of topoisomerase I poisoning by a camptothecin analog

    Bart L. Staker;Kathryn Hjerrild;Michael D. Feese;Craig A. Behnke

  • A model for the mechanism of human topoisomerase I.

    Lance Stewart;Matthew R. Redinbo;Xiayang Qiu;Wim G. J. Hol

  • Canonical Genetic Signatures of the Adult Human Brain

    Michael Hawrylycz;Jeremy A. Miller;Vilas Menon;David Feng

  • De novo design of picomolar SARS-CoV-2 miniprotein inhibitors.

    Longxing Cao;Inna Goreshnik;Brian Coventry;James Brett Case

  • De novo design of potent and selective mimics of IL-2 and IL-15

    Daniel-Adriano Silva;Shawn Yu;Umut Y Ulge;Jamie B Spangler;Jamie B Spangler

  • Massively parallel de novo protein design for targeted therapeutics

    Aaron Chevalier;Daniel-Adriano Silva;Gabriel J. Rocklin;Derrick R. Hicks

  • Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus.

    Jessica Marcandalli;Brooke Fiala;Sebastian Ols;Michela Perotti;Michela Perotti

  • Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

    Alex B Burgin;Olafur T Magnusson;Jasbir Singh;Pam Witte

  • Biological and structural characterization of a host-adapting amino acid in influenza virus.

    Shinya Yamada;Masato Hatta;Bart L. Staker;Shinji Watanabe

  • Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

    Douglas R. Davies;Amy D. Gelinas;Chi Zhang;John C. Rohloff

  • The Domain Organization of Human Topoisomerase I

    Lance Stewart;Gregory C. Ireton;James J. Champoux

  • Quadrivalent influenza nanoparticle vaccines induce broad protection.

    Seyhan Boyoglu-Barnum;Daniel Ellis;Rebecca A. Gillespie;Geoffrey B. Hutchinson

  • Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036.

    Wayne W. Chan;Scott C. Wise;Michael D. Kaufman;Yu Mi Ahn

  • Biochemical and Biophysical Analyses of Recombinant Forms of Human Topoisomerase I

    Lance Stewart;Gregory C. Ireton;Leon H. Parker;Knut R. Madden

  • Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle.

    Philip J. M. Brouwer;Aleksandar Antanasijevic;Zachary Berndsen;Anila Yasmeen

  • Mechanisms of Camptothecin Resistance by Human Topoisomerase I Mutations

    Jill E Chrencik;Bart L Staker;Alex B Burgin;Philippe Pourquier

  • A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

    Christophe Marchand;Smitha Antony;Kurt W. Kohn;Mark Cushman

  • De novo design of modular and tunable protein biosensors.

    Alfredo Quijano-Rubio;Hsien-Wei Yeh;Jooyoung Park;Hansol Lee

  • De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

    Longxing Cao;Inna Goreshnik;Brian Coventry;James Brett Case

Frequent Co-Authors

Peter J. Myler
Peter J. Myler Seattle Children's Hospital
David Baker
David Baker University of Washington
Wesley C. Van Voorhis
Wesley C. Van Voorhis University of Washington
James J. Champoux
James J. Champoux University of Washington
David Veesler
David Veesler University of Washington
Matthew R. Redinbo
Matthew R. Redinbo University of North Carolina at Chapel Hill
Wim G. J. Hol
Wim G. J. Hol University of Washington
Byung-Ha Oh
Byung-Ha Oh Korea Advanced Institute of Science and Technology
Yves Pommier
Yves Pommier National Institutes of Health
Alexandra C. Walls
Alexandra C. Walls University of Washington

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