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Medicine

D-Index
95
Citations
51305
World Ranking
9870
National Ranking
5076

Research.com Recognitions

  • 2018 - Fellow of the American Academy of Arts and Sciences
  • 2016 - Member of the National Academy of Medicine (NAM)
  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2010 - Member of the National Academy of Sciences

Overview

Roger D. Cone is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily spans the fields of Neuroscience and Biochemistry, Genetics and Molecular Biology, with a focus on subfields such as Endocrine and Autonomic Systems, Nutrition and Dietetics, Molecular Biology, Physiology, and Genetics.

The main topics of Cone's research include regulation of appetite and obesity, biochemical analysis and sensing techniques, adipose tissue and metabolism, receptor mechanisms and signaling, eating disorders and behaviors, genetic associations and epidemiology, and dietary effects on health.

Recent notable publications by Roger D. Cone include the following:

  • Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease, 2020, Nature Genetics
  • MC3R links nutritional state to childhood growth and the timing of puberty, 2021, Nature
  • Determination of the melanocortin-4 receptor structure identifies Ca 2+ as a cofactor for ligand binding, 2020, Science
  • Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies, 2020, Addiction Biology
  • Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity, 2022, Nature Metabolism

Frequent co-authors collaborating with Cone include Luis E. Gimenez, Patrick Sweeney, Ciria C. Hernández, Naima S. Dahir, and Savannah Y. Williams.

Publishing extensively, Cone frequently contributes to venues such as bioRxiv (Cold Spring Harbor Laboratory), Journal of Medicinal Chemistry, IUPHAR/BPS Guide to Pharmacology CITE, The Journal of Comparative Neurology, and Journal of Biological Chemistry.

Roger D. Cone has been recognized by professional academies and organizations with multiple memberships and fellowships. These include being a Fellow of the American Academy of Arts and Sciences since 2018, a Member of the National Academy of Medicine since 2016, a Fellow of the American Association for the Advancement of Science since 2012, and a Member of the National Academy of Sciences since 2010.

Best Publications

  • Targeted disruption of the melanocortin-4 receptor results in obesity in mice

    Dennis Huszar;Catherine A Lynch;Victoria Fairchild-Huntress;Judy H Dunmore

  • Gut hormone PYY 3-36 physiologically inhibits food intake

    Rachel L. Batterham;Michael A. Cowley;Caroline J. Small;Herbert Herzog

  • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

    Michael A. Cowley;James L. Smart;Marcelo Rubinstein;Marcelo G. Cerdán

  • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

    W. Fan;B. A. Boston;R. A. Kesterson;V. J. Hruby

  • The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

    Michael A Cowley;Roy G Smith;Sabrina Diano;Matthias Tschöp

  • The cloning of a family of genes that encode the melanocortin receptors

    Kathleen G. Mountjoy;Linda S. Robbins;Marty T. Mortrud;Roger D. Cone

  • Anatomy and regulation of the central melanocortin system.

    Roger D Cone

  • Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

    Kathleen G. Mountjoy;Marty T. Mortrud;Malcolm J. Low;Richard B. Simerly

  • Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor.

    Dongsi Lu;Derril Willard;Indravadan R. Patel;Sue Kadwell

  • Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

    Hunna J. Watson;Hunna J. Watson;Hunna J. Watson;Zeynep Yilmaz;Laura M. Thornton;Christopher Hübel;Christopher Hübel

  • Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function

    Linda S. Robbins;Joseph H. Nadeau;Kenneth R. Johnson;Michele A. Kelly

  • Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

    Baoji Xu;Evan H Goulding;Keling Zang;David Cepoi

  • Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.

    Linda Roselli-Rehfuss;Kathleen G. Mountjoy;Linda S. Robbins;Marty T. Mortrud

  • A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse

    Butler Aa;Kesterson Ra;Khong K;Cullen Mj

  • Cloning and expression of human and rat D1 dopamine receptors

    Qun Yong Zhou;David K. Grandy;Lisa Thambi;Jake A. Kushner

  • Studies on the physiological functions of the melanocortin system

    Roger D. Cone

  • Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus: Evidence of a Cellular Basis for the Adipostat

    Michael A. Cowley;Nina Pronchuk;Wei Fan;Daniela M. Dinulescu

  • The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis

    R D Cone;Michael Alexander Cowley;A A Butler;W Fan

  • The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation

    Roger D. Cone;Dongsi Lu;Sandhya Koppula;Dag Inge Vage

  • Exocrine Gland Dysfunction in MC5-R-Deficient Mice: Evidence for Coordinated Regulation of Exocrine Gland Function by Melanocortin Peptides

    Wenbiao Chen;Michele A Kelly;Ximena Opitz-Araya;Ruth E Thomas

Frequent Co-Authors

Malcolm J. Low
Malcolm J. Low University of Michigan–Ann Arbor
Aarno Palotie
Aarno Palotie University of Helsinki
Martien J H Kas
Martien J H Kas University of Groningen
Ted Reichborn-Kjennerud
Ted Reichborn-Kjennerud University of Oslo
Hunna J. Watson
Hunna J. Watson University of North Carolina at Chapel Hill
Cynthia M. Bulik
Cynthia M. Bulik University of North Carolina at Chapel Hill
Philip Gorwood
Philip Gorwood Université Paris Cité
Stephan Ripke
Stephan Ripke Massachusetts General Hospital
Gerome Breen
Gerome Breen King's College London
Grant W. Montgomery
Grant W. Montgomery University of Queensland

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