World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
88
Citations
32627
World Ranking
13041
National Ranking
6662

Research.com Recognitions

  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Malcolm J. Low is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily spans the fields of Neuroscience and Medicine, with a strong focus on subfields including Endocrine and Autonomic Systems, Molecular Biology, Physiology, Nutrition and Dietetics, and Cellular and Molecular Neuroscience.

The scientific work of Malcolm J. Low addresses key topics such as:

  • Regulation of Appetite and Obesity
  • Biochemical Analysis and Sensing Techniques
  • Adipose Tissue and Metabolism
  • Adipokines, Inflammation, and Metabolic Diseases
  • Receptor Mechanisms and Signaling
  • Neurobiology and Insect Physiology Research
  • Single-cell and spatial transcriptomics

Malcolm J. Low has contributed to several recent papers, which include:

  • Hypothalamic POMC deficiency increases circulating adiponectin despite obesity, 2020, Molecular Metabolism
  • Regulation of Opioid Receptors by Their Endogenous Opioid Peptides, 2021, Cellular and Molecular Neurobiology
  • The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight, 2020, Molecular Metabolism
  • Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency, 2021, Molecular Metabolism
  • Mice lacking PC1/3 expression in POMC-expressing cells do not develop obesity, 2021, Endocrinology

The scientist frequently publishes in journals such as the Journal of the Endocrine Society, Molecular Metabolism, Endocrinology, bioRxiv (Cold Spring Harbor Laboratory), and Cellular and Molecular Neurobiology.

Collaborations have been established with several frequent co-authors, including Marcelo Rubinstein, Hui Yu, Surbhi Gahlot, Zoe Thompson, and Graham L. Jones. These collaborations have contributed to the body of work in their shared fields of interest.

Malcolm J. Low has received recognition in the scientific community, marked by awards like the Fellow of the American Association for the Advancement of Science (AAAS) in 2011 and membership in the Association of American Physicians. These honors reflect engagement with broader scientific organizations.

Best Publications

  • Gut hormone PYY 3-36 physiologically inhibits food intake

    Rachel L. Batterham;Michael A. Cowley;Caroline J. Small;Herbert Herzog

  • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

    Michael A. Cowley;James L. Smart;Marcelo Rubinstein;Marcelo G. Cerdán

  • The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

    Michael A Cowley;Roy G Smith;Sabrina Diano;Matthias Tschöp

  • Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

    Kathleen G. Mountjoy;Marty T. Mortrud;Malcolm J. Low;Richard B. Simerly

  • Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.

    Linda Roselli-Rehfuss;Kathleen G. Mountjoy;Linda S. Robbins;Marty T. Mortrud

  • The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis

    R D Cone;Michael Alexander Cowley;A A Butler;W Fan

  • Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type

    James R. Bunzow;Carmen Saez;Marty Mortrud;Claudia Bouvier

  • Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2

    Sarah C Coste;Robert A Kesterson;Kurt A Heldwein;Susan L Stevens

  • Exocrine Gland Dysfunction in MC5-R-Deficient Mice: Evidence for Coordinated Regulation of Exocrine Gland Function by Melanocortin Peptides

    Wenbiao Chen;Michele A Kelly;Ximena Opitz-Araya;Ruth E Thomas

  • Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine

    Marcelo Rubinstein;Tamara J. Phillips;Tamara J. Phillips;James R. Bunzow;Tomás L. Falzone

  • Activation of central melanocortin pathways by fenfluramine

    Lora K. Heisler;Michael A. Cowley;Laurence H. Tecott;Wei Fan

  • Dopamine D4 Receptor-Knock-Out Mice Exhibit Reduced Exploration of Novel Stimuli

    Stephanie C. Dulawa;David K. Grandy;Malcolm J. Low;Martin P. Paulus

  • Locomotor Activity in D2 Dopamine Receptor-Deficient Mice Is Determined by Gene Dosage, Genetic Background, and Developmental Adaptations

    Michele A. Kelly;Marcelo Rubinstein;Tamara J. Phillips;Christina N. Lessov

  • Pituitary Lactotroph Hyperplasia and Chronic Hyperprolactinemia in Dopamine D2 Receptor-Deficient Mice

    Michele A Kelly;Marcelo Rubinstein;Sylvia L Asa;Ge Zhang

  • Hypothalamic Proopiomelanocortin Neurons Are Glucose Responsive and Express KATP Channels

    Nurhadi Ibrahim;Martha A. Bosch;James L. Smart;Jian Qiu

  • Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors

    Estefanía P Bello;Yolanda Mateo;Diego M Gelman;Daniela Noaín

  • Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function.

    Astrid C. Hauge-Evans;Aileen J. King;Danielle Carmignac;Carolyn C. Richardson

  • Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis.

    M Rubinstein;J S Mogil;M Japón;E C Chan

  • In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development.

    M A Japón;M Rubinstein;M J Low

  • BRIEF COMMUNICATION ARISING: Gut hormone PYY3-36 physiologically inhibits food intake

    Rachel L Batterham;Michael A Alexander Cowley;Caroline J Small;Herbert Herzog

Frequent Co-Authors

Marcelo Rubinstein
Marcelo Rubinstein University of Buenos Aires
David K. Grandy
David K. Grandy Oregon Health & Science University
Roger D. Cone
Roger D. Cone University of Michigan–Ann Arbor
Michael A. Cowley
Michael A. Cowley Monash University
Sylvia L. Asa
Sylvia L. Asa Case Western Reserve University
Mark A. Geyer
Mark A. Geyer University of California, San Diego
John E. Pintar
John E. Pintar Rutgers, The State University of New Jersey
Tamara J. Phillips
Tamara J. Phillips Oregon Health & Science University
Michael S. Levine
Michael S. Levine Princeton University
P. Michael Iuvone
P. Michael Iuvone Emory University

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