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Biology and Biochemistry

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64
Citations
14264
World Ranking
9698
National Ranking
4273

Overview

Jaroslav Jelinek is affiliated with the Coriell Institute For Medical Research in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology. Within these domains, Jelinek has contributed extensively to subfields including Molecular Biology, Genetics, Oncology, Immunology, and Surgery.

The scientist's work addresses several main topics related to molecular and genetic regulation mechanisms. These include:

  • Epigenetics and DNA Methylation
  • Cancer-related gene regulation
  • Genetic Syndromes and Imprinting
  • RNA modifications and cancer
  • Genomics and Chromatin Dynamics
  • Single-cell and spatial transcriptomics
  • Gut microbiota and health

Jelinek's recent publications demonstrate a focus on epigenetic modifications, transcriptomics, and aging processes. Notable papers include:

  • "Promoter methylation changes in ALOX12 and AIRE1: novel epigenetic markers for atherosclerosis" (2020) published in Clinical Epigenetics
  • "Single cell transcriptomic analysis reveals cellular diversity of murine esophageal epithelium" (2022) published in Nature Communications
  • "DNA methylation entropy as a measure of stem cell replication and aging" (2023) published in Genome Biology
  • "TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype" (2023) published in Gastroenterology
  • "Accelerated aging in normal breast tissue of women with breast cancer" (2021) published in Breast Cancer Research

Throughout their career, Jelinek has frequently collaborated with other researchers, including:

  • Jean-Pierre J. Issa
  • Jozef Madžo
  • Kelsey Keith
  • Jumpei Yamazaki
  • Mitsuyoshi Takiguchi

Jelinek's work has been published multiple times in several scientific journals, most notably:

  • Clinical Epigenetics
  • Blood
  • Research in Veterinary Science
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Genome Biology

Best Publications

  • Dnmt3a is essential for hematopoietic stem cell differentiation.

    Grant A. Challen;Deqiang Sun;Mira Jeong;Min Luo

  • Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

    Sonny O. Ang;Hua Chen;Kiichi Hirota;Victor R. Gordeuk

  • JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome–negative CML, and megakaryocytic leukemia

    Jaroslav Jelinek;Yasuhiro Oki;Vazganush Gharibyan;Vazganush Gharibyan;Vazganush Gharibyan;Carlos Bueso-Ramos

  • Epidermal Growth Factor Receptor Copy Number Alterations Correlate With Poor Clinical Outcome in Patients With Head and Neck Squamous Cancer

    Stephane Temam;Hidetoshi Kawaguchi;Adel K El-Naggar;Jaroslav Jelinek

  • Fusobacterium in colonic flora and molecular features of colorectal carcinoma

    Tomomitsu Tahara;Tomomitsu Tahara;Eiichiro Yamamoto;Hiromu Suzuki;Reo Maruyama

  • DNA Methylation Predicts Survival and Response to Therapy in Patients With Myelodysplastic Syndromes

    Lanlan Shen;Hagop Kantarjian;Yi Guo;E. Lin

  • Phase II Study of Low-Dose Decitabine in Patients With Chronic Myelogenous Leukemia Resistant to Imatinib Mesylate

    Jean Pierre F. Issa;Vazganush Gharibyan;Jorge E Cortes;Jaroslav Jelinek

  • LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability.

    Marcos R.H. Estécio;Vazganush Gharibyan;Lanlan Shen;Ashraf E.K. Ibrahim

  • Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines

    Taichun Qin;Jaroslav Jelinek;Jiali Si;Jingmin Shu

  • Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia.

    S. Q. Kuang;W. G. Tong;Hui Yang;W. Lin

  • Caloric restriction delays age-related methylation drift

    Shinji Maegawa;Shinji Maegawa;Yue Lu;Tomomitsu Tahara;Justin T. Lee

  • Polycythemia vera is not initiated by JAK2V617F mutation.

    Roberto H. Nussenzveig;Sabina I. Swierczek;Jaroslav Jelinek;Amos Gaikwad

  • Age-related DNA methylation changes in normal human prostate tissues

    Bernard Kwabi-Addo;Woonbok Chung;Lanlan Shen;Michael Ittmann

  • Epigenetic changes in estrogen receptor β gene in atherosclerotic cardiovascular tissues and in-vitro vascular senescence

    Jei Kim;Jee Yeon Kim;Kyu Sang Song;Young Ho Lee

  • Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation.

    Ting Xi Liu;Michael W. Becker;Jaroslav Jelinek;Wen Shu Wu

  • Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

    Hanghang Zhang;Somnath Pandey;Meghan Travers;Hongxing Sun

  • Correlation between CpG methylation profiles and hormone receptor status in breast cancers

    Weiwei Feng;Lanlan Shen;Sijin Wen;Daniel G. Rosen

  • Discrimination of polycythemias and thrombocytoses by novel, simple, accurate clonality assays and comparison with PRV-1 expression and BFU-E response to erythropoietin

    Enli Liu;Jaroslav Jelinek;Jaroslav Jelinek;Yves D. Pastore;Yves D. Pastore;Yongli Guan;Yongli Guan

  • Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse

    Heike Kroeger;Jaroslav Jelinek;Marcos R.H. Estecio;Rong He

  • Sensitive and Specific Detection of Early Gastric Cancer with DNA Methylation Analysis of Gastric Washes

    Yoshiyuki Watanabe;Yoshiyuki Watanabe;Hyun Soo Kim;Hyun Soo Kim;Ryan J. Castoro;Woonbok Chung

Frequent Co-Authors

Jean Pierre J. Issa
Jean Pierre J. Issa Temple University
Yue Lu
Yue Lu The University of Texas MD Anderson Cancer Center
Hagop M. Kantarjian
Hagop M. Kantarjian The University of Texas MD Anderson Cancer Center
Josef T. Prchal
Josef T. Prchal University of Utah
Carlos E. Bueso-Ramos
Carlos E. Bueso-Ramos The University of Texas MD Anderson Cancer Center
Steven M. Kornblau
Steven M. Kornblau The University of Texas MD Anderson Cancer Center
Srdan Verstovsek
Srdan Verstovsek The University of Texas MD Anderson Cancer Center
Sherry Pierce
Sherry Pierce The University of Texas MD Anderson Cancer Center
Razelle Kurzrock
Razelle Kurzrock Medical College of Wisconsin
Farhad Ravandi
Farhad Ravandi The University of Texas MD Anderson Cancer Center

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