World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
96
Citations
32099
World Ranking
865
National Ranking
468

Medicine

D-Index
95
Citations
31911
World Ranking
10099
National Ranking
5202

Research.com Recognitions

  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2004 - Member of the National Academy of Medicine (NAM)

Overview

William C. Mobley is affiliated with the University of California, San Diego in the United States. Their research spans multiple fields, primarily focusing on medicine and biochemistry, genetics, and molecular biology. Within these broader areas, they have contributed significantly to subfields such as molecular biology, public health, environmental and occupational health, physiology, cellular and molecular neuroscience, and psychiatry and mental health.

The scientist's main research topics include:

  • Down syndrome and intellectual disability research
  • Alzheimer's disease research and treatments
  • Chronic disease management strategies
  • Mitochondrial function and pathology
  • Nerve injury and regeneration
  • Pluripotent stem cells research
  • Cholinesterase and neurodegenerative diseases

William C. Mobley's publication record involves frequent contributions to several noted scientific venues. These include:

  • Alzheimer's & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • NeuroMolecular Medicine
  • Nature
  • eLife

Their recent papers demonstrate engagement with diverse neuroscience and medical topics. Some selected recent publications are:

  • "Reversing a model of Parkinson's disease with in situ converted nigral neurons," 2020, Nature
  • "Enabling Technologies for Personalized and Precision Medicine," 2020, Trends in Biotechnology
  • "Further understanding the connection between Alzheimer's disease and Down syndrome," 2020, Alzheimer's & Dementia
  • "Opportunities, barriers, and recommendations in Down syndrome research," 2021, Translational Science of Rare Diseases
  • "BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons," 2023, eLife

The scientist has collaborated extensively with several frequent co-authors, including:

  • Xu-Qiao Chen
  • Ann Becker
  • André Strydom
  • Elizabeth Head
  • Chengbiao Wu

William C. Mobley's professional recognition includes being named a Fellow of the American Association for the Advancement of Science in 2006 and election as a Member of the National Academy of Medicine in 2004.

Best Publications

  • Nerve growth factor signaling, neuroprotection, and neural repair

    Michael V Sofroniew;Charles L Howe;William C Mobley

  • Characterization and isolation of proteolytically modified nerve growth factor

    William C. Mobley;Anton Schenker;Eric M. Shooter

  • Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment.

    David L. Eaton;Robert B. Daroff;Herman Autrup;James Bridges

  • In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain

    KE Burgin;MN Waxham;S Rickling;SA Westgate

  • Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.

    Alexander M. Kleschevnikov;Pavel V. Belichenko;Angela J. Villar;Charles J. Epstein

  • Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome.

    David M. Holtzman;Daniela Santucci;Joshua Kilbridge;Jane Chua-Couzens

  • Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

    Ahmad Salehi;Jean Dominique Delcroix;Pavel V. Belichenko;Ke Zhan

  • Endocytosis of Activated TrkA: Evidence that Nerve Growth Factor Induces Formation of Signaling Endosomes

    Mark L. Grimes;Jie Zhou;Eric C. Beattie;Eric C. Yuen

  • Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor

    WC Mobley;WC Mobley;JL Rutkowski;GI Tennekoon;K Buchanan

  • NGF Signaling in Sensory Neurons: Evidence that Early Endosomes Carry NGF Retrograde Signals

    Jean-Dominique Delcroix;Janice S. Valletta;Chengbiao Wu;Stephen J. Hunt

  • p140trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF

    David M. Holtzman;Yiwen Li;Luis F. Parada;Stephen Kinsman

  • Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities

    Haruhiko Sago;Elaine J. Carlson;Desmond J. Smith;Joshua Kilbridge

  • Reversing a model of Parkinson’s disease with in situ converted nigral neurons

    Hao Qian;Xinjiang Kang;Jing Hu;Jing Hu;Dongyang Zhang

  • Enabling Technologies for Personalized and Precision Medicine

    Dean Ho;Stephen R. Quake;Edward R.B. McCabe;Wee Joo Chng;Wee Joo Chng

  • One at a time, live tracking of NGF axonal transport using quantum dots.

    Bianxiao Cui;Chengbiao Wu;Liang Chen;Alfredo Ramirez

  • NGF Signaling from Clathrin-Coated Vesicles: Evidence that Signaling Endosomes Serve as a Platform for the Ras-MAPK Pathway

    Charles L Howe;Janice S Valletta;Alex S Rusnak;William C Mobley

  • Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons

    William C. Mobley;William C. Mobley;J.Lynn Rutkowski;Gihan I. Tennekoon;Jude Gemski

  • EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake.

    Andrew Wilde;Eric C Beattie;Lawrence Lem;David A Riethof

  • Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion.

    Jonathan D. Cooper;Ahmad Salehi;Jean-Dominique Delcroix;Charles L. Howe

  • Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.

    Pavel V. Belichenko;Eliezer Masliah;Alexander M. Kleschevnikov;Angela J. Villar

  • Changes in the localization of brain prion proteins during scrapie infection

    S. J. DeArmond;W. C. Mobley;D. L. DeMott;R. A. Barry

Frequent Co-Authors

Pavel V. Belichenko
Pavel V. Belichenko University of California, San Diego
Ahmad Salehi
Ahmad Salehi Stanford University
Charles J. Epstein
Charles J. Epstein University of California, San Francisco
Jonathan D. Cooper
Jonathan D. Cooper Washington University in St. Louis
Robert A. Rissman
Robert A. Rissman University of California, San Diego
Stanley B. Prusiner
Stanley B. Prusiner University of California, San Francisco
Rudolph E. Tanzi
Rudolph E. Tanzi Harvard University
Fred H. Gage
Fred H. Gage Salk Institute for Biological Studies
Stephen J. DeArmond
Stephen J. DeArmond University of California, San Francisco
David M. Holtzman
David M. Holtzman Washington University in St. Louis

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