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Neuroscience

D-Index
70
Citations
14358
World Ranking
2555
National Ranking
36

Research.com Recognitions

  • 2014 - Member of Academia Europaea

Overview

Mara Dierssen is affiliated with Pompeu Fabra University in Spain and has a research profile centered on biochemistry, genetics, molecular biology, and medicine. Their work spans several interconnected fields and topics, with numerous contributions exploring aspects of neurodevelopmental and metabolic disorders.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Dierssen's subfields of study highlight expertise in:

  • Molecular Biology
  • Public Health, Environmental and Occupational Health
  • Genetics
  • Cognitive Neuroscience
  • Geriatrics and Gerontology

Key research topics for Dierssen are:

  • Down syndrome and intellectual disability research
  • Genetics and Neurodevelopmental Disorders
  • Frailty in Older Adults
  • RNA Research and Splicing
  • Chronic Disease Management Strategies
  • Diabetes and associated disorders
  • Cancer-related molecular mechanisms research

Mara Dierssen has contributed to a notable number of publications in various scientific venues. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • European Neuropsychopharmacology
  • PubMed
  • Scientific Reports
  • NeuroMolecular Medicine

Prominent recent papers feature:

  • "Medical vulnerability of individuals with Down syndrome to severe COVID-19-data from the Trisomy 21 Research Society and the UK ISARIC4C survey" (2021) published in EClinicalMedicine
  • "A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction" (2020) published in Nature Communications
  • "Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions" (2020) published in Frontiers in Neuroscience
  • "Prefrontal-hippocampal functional connectivity encodes recognition memory and is impaired in intellectual disability" (2020) published in Proceedings of the National Academy of Sciences
  • "Multi-omics data integration methods and their applications in psychiatric disorders" (2023) published in European Neuropsychopharmacology

Collaborations are a significant aspect of Mara Dierssen's work. Frequent co-authors include:

  • María Martínez de Lagrán
  • André Strydom
  • Álvaro Fernández-Blanco
  • Cèsar Sierra
  • Ilario De Toma

In recognition of their scientific contributions, Mara Dierssen became a member of Academia Europaea in 2014.

Best Publications

  • Cognitive deficits and associated neurological complications in individuals with Down's syndrome.

    Ira T Lott;Mara Dierssen

  • Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down’s syndrome

    Xavier Altafaj;Mara Dierssen;Carmela Baamonde;Eulàlia Martí

  • Dyrk1A Haploinsufficiency Affects Viability and Causes Developmental Delay and Abnormal Brain Morphology in Mice

    Vassiliki Fotaki;Mara Dierssen;Soledad Alcántara;Salvador Martínez

  • Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

    Rafael De la Torre;Susana De Sola;Meritxell Pons;Arnaud Duchon

  • Down syndrome: the brain in trisomic mode

    Mara Dierssen

  • Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes

    Isabel del Pino;Cristina García-Frigola;Nathalie Dehorter;Jorge R. Brotons-Mas

  • Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

    Rafael de la Torre;Susana de Sola;Gimena Hernandez;Magí Farré;Magí Farré

  • A behavioral assessment of Ts65Dn mice: a putative Down syndrome model

    Rosa M. Escorihuela;Alberto Fernández-Teruel;Iria F. Vallina;Carmela Baamonde

  • Fibrinogen drives dystrophic muscle fibrosis via a TGFβ/alternative macrophage activation pathway

    Berta Vidal;Antonio L. Serrano;Marc Tjwa;Mònica Suelves

  • Targeting the endocannabinoid system in the treatment of fragile X syndrome

    Arnau Busquets-Garcia;Maria Gomis-González;Thomas Guegan;Carmen Agustín-Pavón;Carmen Agustín-Pavón

  • Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases

    Jose Rodríguez-Morató;Laura Xicota;Montse Fitó;Magí Farré

  • Dendritic pathology in mental retardation: from molecular genetics to neurobiology.

    M. Dierssen;G. J. A. Ramakers

  • Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice.

    Mireia Garriga-Canut;Carmen Agustín-Pavón;Carmen Agustín-Pavón;Frank Herrmann;Frank Herrmann;Aurora Sánchez

  • Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome

    Carmen Martı́nez-Cué;Carmela Baamonde;Marian Lumbreras;Jesús Paz

  • Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of down syndrome

    A.M. Insausti;M. Megı́as;D. Crespo;L.M. Cruz-Orive

  • Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome

    Rosa M Escorihuela;Iria F Vallina;Carmen Martı́nez-Cué;Carmela Baamonde

  • Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models.

    Isidro Ferrer;Marta Barrachina;Berta Puig;M. Martínez de Lagrán

  • Alterations of Neocortical Pyramidal Cell Phenotype in the Ts65Dn Mouse Model of Down Syndrome: Effects of Environmental Enrichment

    M. Dierssen;Ruth Benavides-Piccione;Carmen Martínez-Cué;X. Estivill

  • Down Syndrome: From Understanding the Neurobiology to Therapy

    Katheleen Gardiner;Yann Herault;Ira T. Lott;Stylianos E. Antonarakis

  • Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system.

    Eulàlia Martı́;Xavier Altafaj;Mara Dierssen;Susana de la Luna

  • Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome

    M. Ayberk Kurt;M. Ilker Kafa;Mara Dierssen;D. Ceri Davies

Frequent Co-Authors

Yann Herault
Yann Herault Institute of Genetics and Molecular and Cellular Biology
Stylianos E. Antonarakis
Stylianos E. Antonarakis University of Geneva
Eduardo D. Martín
Eduardo D. Martín Yale School of Medicine
Jesús Pujol
Jesús Pujol Instituto de Salud Carlos III
Javier DeFelipe
Javier DeFelipe Technical University of Madrid
Isabel Varela-Nieto
Isabel Varela-Nieto Spanish National Research Council
Josep M. Mercader
Josep M. Mercader Broad Institute
Roger H. Reeves
Roger H. Reeves Johns Hopkins University School of Medicine
Manel Esteller
Manel Esteller Josep Carreras Leukaemia Research Institute

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