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Josep M. Mercader

Josep M. Mercader

D-Index & Metrics

Genetics

D-Index
48
Citations
13233
World Ranking
4034
National Ranking
1742

Overview

Josep M. Mercader is a researcher affiliated with the Broad Institute in the United States. Their work spans multiple areas within biochemistry, genetics, and molecular biology, with a particular emphasis on genetics and endocrinology related to diabetes and metabolic diseases.

The main fields of study for Mercader include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields of research cover various specialized areas such as:

  • Genetics
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Surgery
  • Epidemiology

The scientist's research topics focus on genetic associations and epidemiology strongly linked to diabetes, with additional attention to pancreatic function, diabetes treatment, and associated disorders. Other major topics include epigenetics and DNA methylation, nutrition and genetics in disease contexts, and liver disease diagnosis and treatment.

Key topics include:

  • Genetic Associations and Epidemiology
  • Pancreatic function and diabetes
  • Diabetes Treatment and Management
  • Epigenetics and DNA Methylation
  • Diabetes and associated disorders
  • Nutrition, Genetics, and Disease
  • Liver Disease Diagnosis and Treatment

Mercader has published extensively, with notable papers including:

  • Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation, 2022, Nature Genetics
  • Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis, 2021, PLoS Medicine
  • A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease, 2020, PLoS Genetics
  • The impact of non-additive genetic associations on age-related complex diseases, 2021, Nature Communications
  • The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits, 2023, Cell Metabolism

Frequent coauthors contributing collaboratively with Mercader include:

  • José C. Florez
  • Miriam S. Udler
  • Aaron Leong
  • Ravi Mandla
  • Alisa K. Manning

The scientist commonly publishes in venues focused on diabetes and genetics research, with the most frequent publication outlets being:

  • Diabetes
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Diabetes Care
  • Nature Genetics
  • UNC Libraries

Best Publications

  • Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

    Hao Wu;Eduardo Esteve;Eduardo Esteve;Valentina Tremaroli;Muhammad Tanweer Khan

  • SNPassoc: an R package to perform whole genome association studies

    Juan R. González;Lluís Armengol;Xavier Solé;Elisabet Guinó

  • A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

    Klaus Bønnelykke;Patrick Sleiman;Kasper Nielsen;Eskil Kreiner-Møller

  • Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

    Nicole M Warrington;Robin N Beaumont;Momoko Horikoshi;Felix R Day

  • Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia.

    Mònica Gratacòs;Juan R. González;Josep M. Mercader;Rafael de Cid

  • Genome-wide associations for birth weight and correlations with adult disease

    Momoko Horikoshi;Robin N. Beaumont;Felix R. Day;Nicole M. Warrington;Nicole M. Warrington

  • Targeting the Circulating MicroRNA Signature of Obesity

    Francisco José Ortega;Josep María Mercader;Victoria Catalán;Victoria Catalán;José María Moreno-Navarrete

  • Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis.

    Miriam S Udler;Jaegil Kim;Marcin von Grotthuss;Sílvia Bonàs-Guarch

  • Profiling of Circulating MicroRNAs Reveals Common MicroRNAs Linked to Type 2 Diabetes That Change With Insulin Sensitization

    Francisco J Ortega;Josep M Mercader;José María Moreno-Navarrete;Oscar Rovira

  • Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.

    Karol Estrada;Karol Estrada;Ingvild Aukrust;Ingvild Aukrust;Lise Bjørkhaug;Noël P. Burtt

  • Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

    Irene Miguel-Escalada;Silvia Bonàs-Guarch;Inês Cebola;Joan Ponsa-Cobas

  • Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.

    Minako Imamura;Atsushi Takahashi;Toshimasa Yamauchi;Kazuo Hara;Kazuo Hara

  • Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

    Victor Rusu;Eitan Hoch;Josep M Mercader;Danielle E Tenen

  • A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease.

    Connor A. Emdin;Connor A. Emdin;Mary E. Haas;Mary E. Haas;Amit V. Khera;Amit V. Khera;Krishna Aragam;Krishna Aragam

  • Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

    Johannes Waage;Marie Standl;John A. Curtin;Leon E. Jessen

  • Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis.

    Aaron Leong;Joanne B. Cole;Laura N. Brenner;James B. Meigs;James B. Meigs

  • Inflammation triggers specific microRNA profiles in human adipocytes and macrophages and in their supernatants

    Francisco José Ortega;María Moreno;Josep María Mercader;José María Moreno-Navarrete

  • Altered brain-derived neurotrophic factor blood levels and gene variability are associated with anorexia and bulimia.

    J M Mercader;M Ribasés;M Ribasés;M Gratacòs;J R González

  • Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

    Mahajan A;Spracklen Cn;Zhang W;Ng Mc

  • Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

    Victor Rusu;Eitan Hoch;Josep M. Mercader;Danielle E. Tenen

Frequent Co-Authors

David Torrents
David Torrents Barcelona Supercomputing Center
Jose C. Florez
Jose C. Florez Harvard University
Jason Flannick
Jason Flannick Broad Institute
Allan Linneberg
Allan Linneberg University of Copenhagen
Torben Hansen
Torben Hansen University of Copenhagen
Niels Grarup
Niels Grarup University of Copenhagen
José Manuel Fernández-Real
José Manuel Fernández-Real University of Girona
Oluf Pedersen
Oluf Pedersen University of Copenhagen

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