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Neuroscience

D-Index
76
Citations
18207
World Ranking
1946
National Ranking
931

Overview

Long-Jun Wu is a researcher affiliated with the Mayo Clinic in the United States, specializing in neuroscience and medicine, with a strong focus on neuroinflammation and neurodegeneration mechanisms. Their scholarly output spans multiple related subfields, including neurology, molecular biology, immunology, cellular and molecular neuroscience, and physiology. Over their career, they have contributed extensively to understanding the interactions between immune cells and central nervous system function.

The scientist's recent papers cover various aspects of microglial function and neuronal regulation. Among these are:

  • Microglia states and nomenclature: A field at its crossroads (2022), published in Neuron
  • How microglia sense and regulate neuronal activity (2020), published in Glia
  • Microglial calcium signaling is attuned to neuronal activity in awake mice (2020), published in eLife
  • Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system (2021), published in Neurobiology of Disease
  • Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes (2023), published in Neuron

Throughout their research, Long-Jun Wu has collaborated frequently with several scientists, including Jiaying Zheng, Dale B. Bosco, Manling Xie, Shunyi Zhao, and Dai-Shi Tian. These collaborations have supported a consistent publication record across multiple high-impact venues.

The venues where Long-Jun Wu has regularly published include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Brain Behavior and Immunity
  • SSRN Electronic Journal
  • Neuroscience Bulletin
  • IUPHAR/BPS Guide to Pharmacology CITE

Their research addresses key topics such as:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neuroscience and Neuropharmacology Research
  • Immune cells in cancer
  • Pain Mechanisms and Treatments
  • Neurogenesis and neuroplasticity mechanisms
  • Inflammation biomarkers and pathways
  • Adenosine and Purinergic Signaling

With 164 publications in neuroscience and 128 in medicine, Long-Jun Wu's scientific scope integrates cellular-level mechanisms with clinical applications. Their focus on microglia and immune cell signaling reflects ongoing efforts to uncover the complex roles of immune processes in brain health and disease.

Best Publications

  • International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

    Long Jun Wu;Tara Beth Sweet;David E. Clapham

  • Roles of NMDA NR2B Subtype Receptor in Prefrontal Long-Term Potentiation and Contextual Fear Memory

    Ming Gao Zhao;Hiroki Toyoda;Yong Seok Lee;Yong Seok Lee;Long Jun Wu;Long Jun Wu

  • Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

    Ukpong B. Eyo;Jiyun Peng;Przemyslaw Swiatkowski;Aparna Mukherjee

  • Dual Functions of Microglia in Ischemic Stroke

    Chuan Qin;Luo Qi Zhou;Xiao Tong Ma;Zi Wei Hu

  • Enhancement of Learning and Memory by Elevating Brain Magnesium

    Inna Slutsky;Nashat Abumaria;Long Jun Wu;Chao Huang

  • Presynaptic and Postsynaptic Amplifications of Neuropathic Pain in the Anterior Cingulate Cortex

    Hui Xu;Long Jun Wu;Hansen Wang;Xuehan Zhang

  • Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling.

    Yong U. Liu;Yanlu Ying;Yujiao Li;Ukpong B. Eyo;Ukpong B. Eyo

  • TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury.

    Yong Liu;Li Jun Zhou;Li Jun Zhou;Jun Wang;Dai Li

  • Neuronal and microglial mechanisms of neuropathic pain

    Min Zhuo;Gongxiong Wu;Long Jun Wu;Long Jun Wu

  • Deficits in Trace Fear Memory and Long-Term Potentiation in a Mouse Model for Fragile X Syndrome

    Ming Gao Zhao;Hiroki Toyoda;Shanelle W. Ko;Hoi Ki Ding

  • Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway.

    Chuan Qin;Wen Hui Fan;Qian Liu;Ke Shang

  • Microglia-Neuron Communication in Epilepsy.

    Ukpong B. Eyo;Madhuvika Murugan;Long Jun Wu

  • Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

    Jiyun Peng;Nan Gu;Nan Gu;Lijun Zhou;Lijun Zhou;Ukpong B Eyo

  • Upregulation of CREB-Mediated Transcription Enhances Both Short- and Long-Term Memory

    Akinobu Suzuki;Hotaka Fukushima;Takuya Mukawa;Hiroki Toyoda

  • Upregulation of Forebrain NMDA NR2B Receptors Contributes to Behavioral Sensitization after Inflammation

    Long-Jun Wu;Hiroki Toyoda;Ming-Gao Zhao;Yong-Seok Lee

  • The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

    Long–Jun Wu;Gongxiong Wu;M. Reza Akhavan Sharif;Amanda Baker

  • Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain.

    Long Jun Wu;Min Zhuo

  • Bidirectional microglia-neuron communication in the healthy brain.

    Ukpong B. Eyo;Long Jun Wu

  • Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord.

    Long Jun Wu;Long Jun Wu;Bo Duan;Bo Duan;Yi De Mei;Jun Gao;Jun Gao

  • How microglia sense and regulate neuronal activity.

    Anthony D. Umpierre;Long Jun Wu

  • Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of mice with chronic pain.

    Ming Gao Zhao;Shanelle W. Ko;Long Jun Wu;Hiroki Toyoda

Frequent Co-Authors

Min Zhuo
Min Zhuo University of Toronto
Hiroki Toyoda
Hiroki Toyoda Osaka University
Bong-Kiun Kaang
Bong-Kiun Kaang Seoul National University
Tao Chen
Tao Chen Air Force Medical University
Mark P. Mattson
Mark P. Mattson Johns Hopkins University
Xian-Guo Liu
Xian-Guo Liu Sun Yat-sen University
Satoshi Kida
Satoshi Kida University of Tokyo
Feng Wei
Feng Wei University of Maryland, Baltimore
Vanda A. Lennon
Vanda A. Lennon Mayo Clinic

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