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Genetics

D-Index
49
Citations
14094
World Ranking
3975
National Ranking
1718

Research.com Recognitions

  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Katheleen Gardiner is a researcher affiliated with the University of Colorado Denver in the United States. Their work is primarily situated at the intersection of medicine, neuroscience, and biochemistry, genetics, and molecular biology. They have published extensively on topics related to Down syndrome and intellectual disability research, genetics and neurodevelopmental disorders, and autism spectrum disorder research.

Their research emphases also include neuroinflammation and neurodegeneration mechanisms, Alzheimer's disease research and treatments, neuroscience and neuropharmacology research, and ion channel regulation and function. This diverse range highlights a robust engagement with both fundamental genetic aspects and clinical neuroscience concerns.

Gardiner's recent papers include:

  • All Creatures Great and Small: New Approaches for Understanding Down Syndrome Genetics (2020, Trends in Genetics)
  • The innate immune system stimulating cytokine GM-CSF improves learning/memory and interneuron and astrocyte brain pathology in Dp16 Down syndrome mice and improves learning/memory in wild-type mice (2022, Neurobiology of Disease)
  • Altered Protein Profiles During Epileptogenesis in the Pilocarpine Mouse Model of Temporal Lobe Epilepsy (2021, Frontiers in Neurology)
  • Context Fear Conditioning in Down Syndrome Mouse Models: Effects of Trisomic Gene Content, Age, Sex and Genetic Background (2021, Genes)
  • Pro-inflammatory Cytokine GM-CSF Improves Learning/Memory and Brain Pathology in Dp16 Down Syndrome Mice and Improves Learning/Memory in Wild-Type Mice (2021, bioRxiv (Cold Spring Harbor Laboratory))

Frequent coauthors collaborating with Gardiner include Md. Mahiuddin Ahmed, Athena Ching-Jung Wang, Mihret Elos, Heidi J. Chial, and Stefan Sillau. Their joint work spans multiple publications, often focusing on intersections of neurobiology, genetics, and disease models.

Gardiner's typical publication venues are Genes, Trends in Genetics, Neurobiology of Disease, Frontiers in Neurology, and bioRxiv (Cold Spring Harbor Laboratory). These journals reflect the researcher's multidisciplinary approach, involving genetics, neurobiology, and disease mechanisms.

Subfields of their research include public health, environmental and occupational health, genetics, cognitive neuroscience, neurology, and physiology, showing an integrative approach to both molecular and systemic aspects of health and disease.

In recognition of their work, Katheleen Gardiner was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2018.

Best Publications

  • The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

    Cecilia Guerrier-Takada;Katheleen Gardiner;Terry Marsh;Norman Pace

  • The DNA sequence of human chromosome 21

    M. Hattori;A. Fujiyama;T. D. Taylor;H. Watanabe

  • Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

    W.-J. Song;M. G. Sullivan;R. D. Legare;S. Hutchings

  • Fractionation of large mammalian DNA restriction fragments using vertical pulsed-field gradient gel electrophoresis

    Katheleen Gardiner;William Laas;David Patterson

  • Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.

    G Lutfalla;S J Holland;E Cinato;D Monneron

  • Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions.

    Katheleen Gardiner;Andrew Fortna;Lawrence Bechtel;Muriel T Davisson

  • Down syndrome and Alzheimer's disease: Common pathways, common goals.

    Dean Hartley;Thomas Blumenthal;Maria Carrillo;Gilbert DiPaolo

  • Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions.

    Katheleen Gardiner;Michel Horisberger;Jan Kraus;Umadevi Tantravahi

  • Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts.

    Donald E. Kuhn;Gerard J. Nuovo;Mickey M. Martin;Geraldine E. Malana

  • Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

    Sergey V. Voronov;Samuel G. Frere;Silvia Giovedi;Elizabeth A. Pollina

  • Down Syndrome: From Understanding the Neurobiology to Therapy

    Katheleen Gardiner;Yann Herault;Ira T. Lott;Stylianos E. Antonarakis

  • Self-Organizing Feature Maps Identify Proteins Critical to Learning in a Mouse Model of Down Syndrome

    Clara Higuera;Katheleen J. Gardiner;Krzysztof J. Cios

  • Mouse models of Down syndrome: gene content and consequences.

    Meenal Gupta;A Ranjitha Dhanasekaran;Katheleen J Gardiner

  • Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions

    Xiaolu Sturgeon;Katheleen J. Gardiner

  • The structure of the human interferon alpha/beta receptor gene.

    G Lutfalla;K Gardiner;D Proudhon;E Vielh

  • Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations

    Katheleen J Gardiner

  • A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR

    Georges Lutfalla;Katheleen Gardiner;Gilles Uzé

  • Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome.

    E C Akeson;J P Lambert;S Narayanswami;K Gardiner

  • RNase P of Bacillus subtilis has a RNA component.

    K. Gardiner;N.R. Pace

  • Comparative Genomic Analysis of the Interferon/Interleukin-10 Receptor Gene Cluster

    Jérôme Reboul;Katheleen Gardiner;Danièle Monneron;Gilles Uzé

Frequent Co-Authors

Krzysztof J. Cios
Krzysztof J. Cios Virginia Commonwealth University
Muriel T. Davisson
Muriel T. Davisson University of California, Los Angeles
Flora Tassone
Flora Tassone University of California, Davis
Sherman M. Weissman
Sherman M. Weissman Yale University
Roger H. Reeves
Roger H. Reeves Johns Hopkins University School of Medicine
Georges Lutfalla
Georges Lutfalla University of Montpellier
Antonio Baldini
Antonio Baldini University of Naples Federico II
John K. Cowell
John K. Cowell Augusta University
Harry A. Drabkin
Harry A. Drabkin Medical University of South Carolina
Stylianos E. Antonarakis
Stylianos E. Antonarakis University of Geneva

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