Franz Hefti

Best Publications

• Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

  Unknown

  1455
  Citations

• Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors

  Mark S. Kramer;Neal Cutler;John Feighner;Ram Shrivastava

  1372
  Citations

• Characterization of a multicomponent receptor for GDNF

  James J. S. Treanor;Laurie Goodman;Frederic de Sauvage;Donna M. Stone

  1344
  Citations

• Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

  Y. Iturria-Medina;R. C. Sotero;P. J. Toussaint;J. M. Mateos-Pérez

  1176
  Citations

• Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain

  Klaus D. Beck;Janet Valverde;Tajrena Alexi;Kris Poulsen

  1001
  Citations

• Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons

  K D Beck;L Powell-Braxton;H R Widmer;J Valverde

  947
  Citations

• Precursor control of neurotransmitter synthesis.

  R J Wurtman;F Hefti;E Melamed

  904
  Citations

• Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.

  Beat Knusel;John W. Winslow;Arnon Rosenthal;Louis E. Burton

  900
  Citations

• NGF-Mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: Evidence for a physiological role of NGF in the brain?

  H. Gnahn;F. Hefti;R. Heumann;M.E. Schwab

  835
  Citations

• Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II

  B Knusel;PP Michel;JS Schwaber;F Hefti

  797
  Citations

• Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases.

  F. Hefti;J. Hartikka;B. Knusel

  687
  Citations

• Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization

  Franz Hefti;Eldad Melamed;Richard J. Wurtman

  646
  Citations

• Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

  Alexandra L Young;Razvan V Marinescu;Neil P Oxtoby;Martina Bocchetta

  568
  Citations

• Novel class of pain drugs based on antagonism of NGF

  Franz F. Hefti;Arnon Rosenthal;Patricia A. Walicke;Sean Wyatt

  564
  Citations

• Nerve growth factor and Alzheimer's disease.

  Franz Hefti;William J. Weiner

  541
  Citations

• Nerve growth factor increases choline acetyl-transferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons

  F. Hefti;J. Hartikka;F. Eckenstein;H. Gnahn

  532
  Citations

• Toxicity of 6-hydroxydopamine and dopamine for dopaminergic neurons in culture

  P. P. Michel;F. Hefti

  499
  Citations

• Development of septal cholinergic neurons in culture: plating density and glial cells modulate effects of NGF on survival, fiber growth, and expression of transmitter-specific enzymes

  J Hartikka;F Hefti

  471
  Citations

• Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions

  Unknown

  447
  Citations

• Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons.

  Laurie J. Goodman;Janet Valverde;Filip Lim;Michael D. Geschwind

  416
  Citations