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Biology and Biochemistry

D-Index
88
Citations
26620
World Ranking
2710
National Ranking
1407

Overview

Kim E. Nichols is affiliated with St. Jude Children's Research Hospital in the United States. Their research spans multiple intersecting fields of medicine, with a focus on pediatric cancer and related genetic and immunological conditions.

The primary fields of study for Nichols include Medicine and Biochemistry, Genetics and Molecular Biology. More specifically, their work involves Molecular Biology, Hematology, Genetics, Pediatrics, Perinatology and Child Health, and Immunology as subfields.

The main topics they have explored in their research consist of:

  • Autoimmune and Inflammatory Disorders Research
  • Childhood Cancer Survivors' Quality of Life
  • Immune Cell Function and Interaction
  • Cancer Genomics and Diagnostics
  • Acute Lymphoblastic Leukemia research
  • Epigenetics and DNA Methylation
  • Acute Myeloid Leukemia Research

Kim E. Nichols has published numerous papers, among which are:

  • "St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem," 2021, Cancer Discovery
  • "Germline Elongator mutations in Sonic Hedgehog medulloblastoma," 2020, Nature
  • "Use of the JAK Inhibitor Ruxolitinib in the Treatment of Hemophagocytic Lymphohistiocytosis," 2021, Frontiers in Immunology
  • "Mutational Landscape and Patterns of Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia," 2020, Blood Cancer Discovery
  • "Cohort Profile: The St. Jude Lifetime Cohort Study (SJLIFE) for paediatric cancer survivors," 2020, International Journal of Epidemiology

Frequent collaborators in their work include Rose B. McGee, Ninad Oak, Jinghui Zhang, David Malkin, and Gang Wu.

Common venues where Nichols publishes research include Blood, Clinical Cancer Research, Cancer Research, Neuro-Oncology, and Frontiers in Immunology.

Best Publications

  • Germline Mutations in Predisposition Genes in Pediatric Cancer

    Jinghui Zhang;Michael F. Walsh;Gang Wu;Michael N. Edmonson

  • SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation.

    Jens M. Chemnitz;Richard V. Parry;Kim E. Nichols;Carl H. June

  • Recommendations for the management of hemophagocytic lymphohistiocytosis in adults

    Paul La Rosée;Anna Carin Horne;Melissa Hines;Tatiana Von Bahr Greenwood

  • 2016 Classification criteria for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: A European league against Rheumatism/American college of Rheumatology/Paediatric rheumatology international trials organisation collaborative initiative

    Angelo Ravelli;Francesca Serena Minoia;Sergio Davi;Anna Carin Horne

  • Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy.

    David T. Teachey;David T. Teachey;Susan R. Rheingold;Susan R. Rheingold;Shannon L. Maude;Shannon L. Maude;Gerhard Zugmaier

  • Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1.

    Kim E. Nichols;John D. Crispino;Mortimer Poncz;James G. White

  • Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

    Kim E. Nichols;D. Paul Harkin;Seth Levitz;Michael Krainer

  • The Immunology of Macrophage Activation Syndrome.

    Courtney B. Crayne;Sabrin Albeituni;Kim E. Nichols;Randy Q. Cron

  • Regulation of NKT cell development by SAP, the protein defective in XLP.

    Kim E. Nichols;Jamie Hom;Shun You Gong;Arupa Ganguly

  • Germ-line p53 Mutations Predispose to a Wide Spectrum of Early-onset Cancers

    Kim E. Nichols;David Malkin;Judy E. Garber;Joseph F. Fraumeni

  • 2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis

    Angelo Ravelli;Francesca Minoia;Sergio Davì;Annacarin Horne

  • Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: Recommendations from the North American Consortium for Histiocytosis (NACHO).

    Michael B. Jordan;Carl E. Allen;Jay Greenberg;Michael Henry

  • Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D

    Benjamin Chaigne-Delalande;Feng-Yen Li;Feng-Yen Li;Geraldine M. O’Connor;Marshall J. Lukacs

  • The genetic basis and cell of origin of mixed phenotype acute leukaemia

    Thomas B. Alexander;Thomas B. Alexander;Zhaohui Gu;Ilaria Iacobucci;Kirsten Dickerson

  • X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management, and outcome of the disease

    Claire Booth;Kimberly C. Gilmour;Paul Veys;Andrew R. Gennery

  • Regulation of Cellular and Humoral Immune Responses by the SLAM and SAP Families of Molecules

    Cindy S. Ma;Kim E. Nichols;Stuart G. Tangye

  • SAP Regulates TH2 Differentiation and PKC-θ-Mediated Activation of NF-κB1

    Jennifer L. Cannons;Li J. Yu;Brenna Hill;Brenna Hill;Lilia A. Mijares

  • Cutting Edge: Functional Requirement for SAP in 2B4-Mediated Activation of Human Natural Killer Cells as Revealed by the X-Linked Lymphoproliferative Syndrome

    Stuart G. Tangye;Joseph H. Phillips;Lewis L. Lanier;Kim E. Nichols

  • Treatment of Epstein Barr virus-induced haemophagocytic lymphohistiocytosis with rituximab-containing chemo-immunotherapeutic regimens

    DeepakBabu Chellapandian;Rupali Das;Kristin Zelley;Susan J. Wiener

  • Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome (Epstein-Barr virusyimmunodeficiencyylymphoma)

    Kim E. Nichols;Seth Levitz;Michael Krainer;Kathryn Ann Kolquist

Frequent Co-Authors

Gang Wu
Gang Wu Washington University in St. Louis
Jinghui Zhang
Jinghui Zhang St. Jude Children's Research Hospital
Stuart G. Tangye
Stuart G. Tangye Garvan Institute of Medical Research
James R. Downing
James R. Downing St. Jude Children's Research Hospital
Charles G. Mullighan
Charles G. Mullighan St. Jude Children's Research Hospital
Michael Rusch
Michael Rusch St. Jude Children's Research Hospital
Zhaoming Wang
Zhaoming Wang St. Jude Children's Research Hospital
Ching-Hon Pui
Ching-Hon Pui St. Jude Children's Research Hospital
Leslie L. Robison
Leslie L. Robison St. Jude Children's Research Hospital
John Easton
John Easton St. Jude Children's Research Hospital

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