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Biology and Biochemistry

D-Index
55
Citations
23017
World Ranking
14750
National Ranking
6166

Overview

Michael Rusch is affiliated with St. Jude Children's Research Hospital in the United States. Their research focuses primarily on areas within biochemistry, genetics, and molecular biology, with significant contributions to medicine. Their work is concentrated in subfields including molecular biology, cancer research, hematology, genetics, and public health, environmental and occupational health.

The scientist's research topics cover several key domains:

  • Cancer Genomics and Diagnostics
  • Acute Myeloid Leukemia Research
  • Acute Lymphoblastic Leukemia Research
  • Epigenetics and DNA Methylation
  • RNA Modifications and Cancer
  • Genomics and Chromatin Dynamics
  • RNA Research and Splicing

Michael Rusch has contributed to numerous publications, frequently appearing in venues such as Cancer Research, Zenodo (CERN European Organization for Nuclear Research), Nature Genetics, Nature Communications, and Blood Cancer Discovery. The scientist has co-authored multiple recent papers, including:

  • The genomic landscape of pediatric acute lymphoblastic leukemia (2022, Nature Genetics)
  • St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem (2021, Cancer Discovery)
  • Germline Elongator mutations in Sonic Hedgehog medulloblastoma (2020, Nature)
  • Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations (2020, Nature Communications)
  • Mutational Landscape and Patterns of Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia (2020, Blood Cancer Discovery)

Collaborative work is an important aspect of Michael Rusch's research. Frequent co-authors include:

  • Jinghui Zhang
  • Michael N. Edmonson
  • John Easton
  • Charles G. Mullighan
  • Xiaotu Ma

The body of work involves high-impact research in pediatric cancers and genetic mutations, particularly focusing on leukemia and neuroblastoma. Their research also intersects with data-sharing ecosystems that facilitate collaborative genomic studies.

Best Publications

  • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

    Jinghui Zhang;Li Ding;Linda Holmfeldt;Gang Wu

  • Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

    K. G. Roberts;Y. Li;D. Payne-Turner;R. C. Harvey

  • Germline Mutations in Predisposition Genes in Pediatric Cancer

    Jinghui Zhang;Michael F. Walsh;Gang Wu;Michael N. Edmonson

  • The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

    Gang Wu;Alexander K Diaz;Alexander K Diaz;Barbara S Paugh;Sherri L Rankin

  • The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia

    Yu Liu;John Easton;Ying Shao;Jamie Maciaszek

  • Novel mutations target distinct subgroups of medulloblastoma

    Giles Robinson;Matthew Parker;Tanya A. Kranenburg;Charles Lu;Charles Lu

  • Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours

    Xiaotu Ma;Yu Liu;Yanling Liu;Ludmil B. Alexandrov

  • Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

    Jinghui Zhang;Gang Wu;Claudia P. Miller;Ruth G. Tatevossian

  • The genomic landscape of hypodiploid acute lymphoblastic leukemia

    Linda Holmfeldt;Lei Wei;Ernesto Diaz-Flores;Michael Walsh

  • Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

    Xiang Chen;Armita Bahrami;Alberto Pappo;John Easton

  • C11orf95 – RELA fusions drive oncogenic NF-κB signalling in ependymoma

    Matthew Parker;Kumarasamypet M. Mohankumar;Chandanamali Punchihewa;Ricardo Weinlich

  • CREST maps somatic structural variation in cancer genomes with base-pair resolution

    Jianmin Wang;Charles G Mullighan;John Easton;Stefan Roberts

  • A novel retinoblastoma therapy from genomic and epigenetic analyses

    Jinghui Zhang;Claudia A. Benavente;Justina McEvoy;Jacqueline Flores-Otero

  • Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations

    Franck Tirode;Didier Surdez;Xiaotu Ma;Matthew Parker

  • The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias.

    Anna K. Andersson;Anna K. Andersson;Jing Ma;Jianmin Wang;Xiang Chen

  • Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

    Giles W. Robinson;Brent A. Orr;Gang Wu;Sridharan Gururangan

  • Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia

    Xiaotu Ma;Michael Edmonson;Donald Yergeau;Donna M Muzny

  • The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

    Robert Huether;Li Dong;Xiang Chen;Gang Wu

  • Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology

    Ibrahim Qaddoumi;Wilda Orisme;Ji Wen;Teresa Santiago

  • A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

    Sohela Shah;Kasmintan A. Schrader;Esmé Waanders;Andrew E. Timms

Frequent Co-Authors

Jinghui Zhang
Jinghui Zhang St. Jude Children's Research Hospital
James R. Downing
James R. Downing St. Jude Children's Research Hospital
John Easton
John Easton St. Jude Children's Research Hospital
Gang Wu
Gang Wu St. Jude Children's Research Hospital
Charles G. Mullighan
Charles G. Mullighan St. Jude Children's Research Hospital
Elaine R. Mardis
Elaine R. Mardis The Ohio State University
Richard K. Wilson
Richard K. Wilson Nationwide Children's Hospital
Li Ding
Li Ding Washington University in St. Louis
David W. Ellison
David W. Ellison St. Jude Children's Research Hospital
Sheila A. Shurtleff
Sheila A. Shurtleff St. Jude Children's Research Hospital

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