C. I. E. Smith

What is he best known for?

The fields of study he is best known for:

• Gene
• DNA
• Antibody

C. I. E. Smith spends much of his time researching Immunology, Bruton's tyrosine kinase, Molecular biology, Antibody and Tyrosine kinase. Within one scientific family, he focuses on topics pertaining to Receptor under Immunology, and may sometimes address concerns connected to Interferon gamma and Clinical disease. He studies Bruton's tyrosine kinase, namely X-linked agammaglobulinemia.

C. I. E. Smith has researched Molecular biology in several fields, including Cell culture, Gene rearrangement, Virology, B cell and COS cells. His research on Antibody focuses in particular on Subclass. His biological study spans a wide range of topics, including K562 cells and Kinase.

His most cited work include:

• Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes (546 citations)
• Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase. (503 citations)
• The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species (256 citations)

What are the main themes of his work throughout his whole career to date?

C. I. E. Smith mainly focuses on Immunology, Antibody, Molecular biology, Subclass and Genetics. His research is interdisciplinary, bridging the disciplines of Antigen and Antibody. His studies deal with areas such as Immunoglobulin heavy chain, Tyrosine kinase, Bruton's tyrosine kinase, Southern blot and B cell as well as Molecular biology.

His Bruton's tyrosine kinase research is multidisciplinary, incorporating elements of Mutation, X chromosome and Kinase, Pleckstrin homology domain. His B cell research includes elements of Lipopolysaccharide and Polyclonal antibodies. His Subclass study combines topics from a wide range of disciplines, such as Specific antibody, Vaccination, Virology, Distribution and Monoclonal antibody.

He most often published in these fields:

• Immunology (50.63%)
• Antibody (40.08%)
• Molecular biology (26.58%)

What were the highlights of his more recent work (between 1998-2017)?

• Immunology (50.63%)
• Bruton's tyrosine kinase (14.35%)
• Biochemistry (8.44%)

In recent papers he was focusing on the following fields of study:

C. I. E. Smith spends much of his time researching Immunology, Bruton's tyrosine kinase, Biochemistry, Antibody and Molecular biology. Immunology and Virology are frequently intertwined in his study. His study with Bruton's tyrosine kinase involves better knowledge in Tyrosine kinase.

C. I. E. Smith mostly deals with X-linked agammaglobulinemia in his studies of Tyrosine kinase. His Antibody study integrates concerns from other disciplines, such as Receptor and Antigen. His studies in Molecular biology integrate themes in fields like Cell culture, Bystander effect, Transcription factor, Gene and In vivo.

Between 1998 and 2017, his most popular works were:

• The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species (256 citations)
• Intercellular delivery of thymidine kinase prodrug activating enzyme by the herpes simplex virus protein, VP22 (163 citations)
• Mutations of the human BTK gene coding for bruton tyrosine kinase in X-linked agammaglobulinemia. (99 citations)

In his most recent research, the most cited papers focused on:

• Gene
• DNA
• Antibody

His scientific interests lie mostly in Bruton's tyrosine kinase, Immunology, Tyrosine kinase, Kinase and Mutation. His work in Immunology is not limited to one particular discipline; it also encompasses Typing. His Tyrosine kinase study is concerned with the larger field of Cell biology.

His Kinase study also includes fields such as

• Lymphoma, which have a strong connection to Autoimmunity, T cell, Immunodeficiency, Adverse effect and B cell,
• Ibrutinib together with Pharmacology. His research in Mutation tackles topics such as X-linked agammaglobulinemia which are related to areas like Protein structure. His Antigen research includes themes of Antibody, HLA-DR3 and Distribution.