His primary areas of investigation include Immunology, Common variable immunodeficiency, Antibody, Immunoglobulin class switching and Molecular biology. His Immunology study typically links adjacent topics like Mutation. His Common variable immunodeficiency study integrates concerns from other disciplines, such as Immunoglobulin G, Primary immunodeficiency, Clinical course and Pneumonia.
His Antibody course of study focuses on Spleen and Marginal zone and Immune system. His biological study spans a wide range of topics, including Hyper IgM syndrome, Germinal center, Cytidine deaminase, Receptor and B-cell activating factor. His study explores the link between Germinal center and topics such as Internal medicine that cross with problems in CD40.
Alessandro Plebani spends much of his time researching Immunology, Common variable immunodeficiency, Genetics, Antibody and Primary immunodeficiency. Immunology is frequently linked to Disease in his study. His studies in Common variable immunodeficiency integrate themes in fields like Selective IgA deficiency and Pathology.
His research combines Molecular biology and Genetics. His Primary immunodeficiency research is multidisciplinary, incorporating perspectives in Incidence and Pediatrics. His Pediatrics research includes elements of Cohort study and Cohort.
His primary scientific interests are in Immunology, Primary immunodeficiency, Common variable immunodeficiency, Disease and Hypogammaglobulinemia. His research brings together the fields of Clinical course and Immunology. His Primary immunodeficiency study combines topics from a wide range of disciplines, such as Hematopoietic stem cell transplantation, Immune dysregulation, Pediatrics and Intensive care.
His Common variable immunodeficiency research integrates issues from Genetic counseling, Intellectual disability and Family medicine. His research integrates issues of CTLA-4, Recurrent infections, B cell and Lymphoma in his study of Hypogammaglobulinemia. Alessandro Plebani combines subjects such as Haematopoiesis, CD40, Immunoglobulin class switching, Somatic hypermutation and Cytidine deaminase with his study of Immune system.
The scientist’s investigation covers issues in Primary immunodeficiency, Immunodeficiency, Immunology, Common variable immunodeficiency and Internal medicine. His biological study spans a wide range of topics, including Immune dysregulation, Pediatrics and Intensive care. His Immunodeficiency research includes themes of X-linked agammaglobulinemia, Disease and Mutation.
Immunology is often connected to Hyper IgM syndrome in his work. In his research on the topic of Common variable immunodeficiency, Pneumonia is strongly related with Hypogammaglobulinemia. Alessandro Plebani has researched Activation-induced deaminase in several fields, including Germinal center, Cytidine deaminase and CD40.
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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).
Patrick Revy;Taro Muto;Yves Levy;Frédéric Geissmann.
Human blood IgM “memory” B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire
Sandra Weller;Moritz C. Braun;Bruce K. Tan;Andreas Rosenwald.
The EUROclass trial: defining subgroups in common variable immunodeficiency
Claudia Wehr;Teemu Kivioja;Christian Schmitt;Berne Ferry.
A Homozygous CARD9 Mutation in a Family with Susceptibility to Fungal Infections
Erik-Oliver Glocker;Andre Hennigs;Mohammad Nabavi;Alejandro A. Schäffer.
The New England Journal of Medicine (2009)
Intestinal Bacteria Trigger T Cell-Independent Immunoglobulin A2 Class Switching by Inducing Epithelial-Cell Secretion of the Cytokine APRIL
Bing He;Weifeng Xu;Paul A. Santini;Alexandros D. Polydorides.
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.
Dietke Buck;Laurent Malivert;Régina de Chasseval;Anne Barraud.
Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen.
Stephanie Kruetzmann;M. Manuela Rosado;Holger Weber;Ulrich Germing.
Journal of Experimental Medicine (2003)
B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen
Irene Puga;Montserrat Cols;Carolina M. Barra;Bing-Yang He.
Nature Immunology (2012)
Long-Term Follow-Up and Outcome of a Large Cohort of Patients with Common Variable Immunodeficiency
Isabella Quinti;Annarosa Soresina;Giuseppe Spadaro;Silvana Martino.
Journal of Clinical Immunology (2007)
Deleterious Mutations in LRBA Are Associated with a Syndrome of Immune Deficiency and Autoimmunity
Gabriela Lopez-Herrera;Giacomo Tampella;Qiang Pan-Hammarström;Peer Herholz.
American Journal of Human Genetics (2012)
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