World's Best Scientists 2026 revealed!

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Biology and Biochemistry

D-Index
141
Citations
64206
World Ranking
265
National Ranking
181

Medicine

D-Index
141
Citations
64156
World Ranking
1642
National Ranking
957

Research.com Recognitions

  • 1997 - Member of the National Academy of Sciences
  • 1996 - Fellow of the American Academy of Arts and Sciences

Overview

Owen N. Witte is affiliated with the University of California, Los Angeles in the United States. Their research spans multiple disciplines within biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology and oncology.

Their recent publications include the following papers:

  • The DNA methylation landscape of advanced prostate cancer, 2020, Nature Genetics
  • Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance, 2020, Proceedings of the National Academy of Sciences
  • Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy, 2021, Cell Reports Medicine
  • Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers, 2020, Proceedings of the National Academy of Sciences
  • Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation, 2023, Cancer Cell

They frequently collaborate with other researchers, including Donghui Cheng, Zhiyuan Mao, Rahul Aggarwal, Joshi J. Alumkal, and Tomasz M. Beer.

Witte's work has been published in several notable venues such as:

  • Proceedings of the National Academy of Sciences
  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Journal of Clinical Oncology

The main fields of study for their research include biochemistry, genetics and molecular biology, and medicine. Within these fields, subfields of molecular biology, oncology, pulmonary and respiratory medicine, immunology, and cancer research are well represented.

The scientist's primary research topics cover:

  • Prostate cancer treatment and research
  • CAR-T cell therapy research
  • RNA modifications and cancer
  • RNA research and splicing
  • Cancer-related gene regulation
  • Immune cell function and interaction
  • Immunotherapy and immune responses

Recognition awarded to Owen N. Witte includes being named a Member of the National Academy of Sciences in 1997 and a Fellow of the American Academy of Arts and Sciences in 1996.

Best Publications

  • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

    Tracy G. Lugo;Ann-Marie Pendergast;Alexander J. Muller;Owen N. Witte

  • Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

    Satoshi Tsukada;Douglas C. Saffran;David J. Rawlings;Ornella Parolini;Ornella Parolini

  • An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

    James B. Konopka;Susan M. Watanabe;Owen N. Witte

  • Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

    David J. Rawlings;Douglas C. Saffran;Satoshi Tsukada;David A. Largaespada

  • The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene.

    Yinon Ben-Neriah;George Q. Daley;Anne-Marie Mes-Masson;Owen N. Witte

  • Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer

    Robert E. Reiter;Zhennen Gu;Tetsuro Watabe;George Thomas

  • Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.

    Ernest S. Kawasaki;Steven S. Clark;Mazie Y. Coyne;Stephen D. Smith

  • Long-term culture of B lymphocytes and their precursors from murine bone marrow.

    Cheryl A. Whitlock;Owen N. Witte

  • Identification of a Cell of Origin for Human Prostate Cancer

    Andrew S. Goldstein;Jiaoti Huang;Changyong Guo;Isla P. Garraway

  • Differential expression of myc family genes during murine development

    Kathryn A. Zimmerman;George D. Yancopoulos;Robert G. Collum;Russell K. Smith

  • Steel locus defines new multipotent growth factor.

    Owen N. Witte

  • Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL

    Michelle A. Kelliher;Jami McLaughlin;Owen N. Witte;Naomi Rosenberg

  • Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics.

    Chung-Cheng Lee;Guodong Sui;Arkadij Elizarov;Chengyi Jenny Shu

  • Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

    David A. Quigley;Ha X. Dang;Shuang G. Zhao;Paul Lloyd

  • Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study

    Rahul Aggarwal;Jiaoti Huang;Joshi J. Alumkal;Li Zhang

  • Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer.

    Gu Z;Thomas G;Yamashiro J;Shintaku Ip

  • Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine.

    Owen N. Witte;Asim Dasgupta;David Baltimore

  • Dominant negative MYC blocks transformation by ABL oncogenes

    Charles L. Sawyers;Wendy Callahan;Owen N. Witte

  • Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: Studies with cloned viral DNA

    Stephen P. Goff;Eli Gilboa;Owen N. Witte;David Baltimore

  • The BCR-ABL Story: Bench to Bedside and Back

    Stephane Wong;Owen N Witte

Frequent Co-Authors

Caius G. Radu
Caius G. Radu University of California, Los Angeles
Jiaoti Huang
Jiaoti Huang Duke University
Robert E. Reiter
Robert E. Reiter University of California, Los Angeles
Antoni Ribas
Antoni Ribas University of California, Los Angeles
David Baltimore
David Baltimore California Institute of Technology
David J. Rawlings
David J. Rawlings Seattle Children's Hospital
Charles L. Sawyers
Charles L. Sawyers Memorial Sloan Kettering Cancer Center
Martin E. Gleave
Martin E. Gleave University of British Columbia
Tomasz M. Beer
Tomasz M. Beer Oregon Health & Science University

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