Member of the Association of American Physicians
His primary scientific interests are in Cell biology, B cell, Immunology, Bruton's tyrosine kinase and Tyrosine kinase. His Cell biology research integrates issues from Innate immune system and Biochemistry. His B cell research is multidisciplinary, incorporating elements of B-1 cell, Antigen-presenting cell and Immune system.
His work in Autoimmunity, Germinal center, Antibody, T cell and Antigen are all subfields of Immunology research. His Bruton's tyrosine kinase research includes themes of SH3 domain, Molecular biology and Kinase. His studies deal with areas such as Cancer research, Pleckstrin homology domain, Protein kinase A, Point mutation and Tyrosine phosphorylation as well as Tyrosine kinase.
Immunology, B cell, Molecular biology, Cell biology and Genetic enhancement are his primary areas of study. His Immunology research focuses on Immune system, Antibody, Autoimmunity, Antigen and Germinal center. His B cell study incorporates themes from T cell, Cancer research and Autoantibody.
The Molecular biology study combines topics in areas such as Haematopoiesis, Gene, Genome editing, Bruton's tyrosine kinase and Homology directed repair. His Cell biology research is multidisciplinary, incorporating perspectives in Transcription factor and T-cell receptor. The various areas that David J. Rawlings examines in his Genetic enhancement study include Virology, Viral vector, Stem cell and Severe combined immunodeficiency, In vivo.
David J. Rawlings mostly deals with Antigen, Immunology, Antibody, Genome editing and Molecular biology. His biological study spans a wide range of topics, including Receptor and Disease. His Antibody research incorporates elements of Virus and Function.
His work deals with themes such as Haematopoiesis, Stem cell, Recombinant DNA and B-cell receptor, B cell, which intersect with Molecular biology. David J. Rawlings connects B cell with Translational elongation in his research. His Immune system research is multidisciplinary, incorporating elements of Phenotype and Cell biology.
His primary areas of study are Immunology, Transplantation, Molecular biology, Receptor and Stem cell. His study in Antigen, Virus and Antibody is carried out as part of his studies in Immunology. The study incorporates disciplines such as Survival rate, Wiskott–Aldrich syndrome and Immunodeficiency in addition to Transplantation.
His research in Molecular biology intersects with topics in Reversion and Homology directed repair. The various areas that he examines in his Receptor study include T cell, Germinal center, Systemic lupus erythematosus, Interleukin 12 and Autoimmunity. His biological study spans a wide range of topics, including Humanized mouse, Fetal hemoglobin, Hereditary persistence of fetal hemoglobin and Transfection.
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CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients
Paul A. Blair;Lina Yassin Noreña;Fabian Flores-Borja;David J. Rawlings.
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia
Satoshi Tsukada;Douglas C. Saffran;David J. Rawlings;Ornella Parolini;Ornella Parolini.
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice.
D J Rawlings;D C Saffran;S Tsukada;D A Largaespada.
Novel Suppressive Function of Transitional 2 B Cells in Experimental Arthritis
Jamie G. Evans;Karina A. Chavez-Rueda;Ayad Eddaoudi;Almut Meyer-Bahlburg.
Journal of Immunology (2007)
BTK/TEC KINASES REGULATE SUSTAINED INCREASES IN INTRACELLULAR CA2+ FOLLOWING B-CELL RECEPTOR ACTIVATION
Anne Catherine Fluckiger;Zuomei Li;Roberta M. Kato;Matthew I. Wahl.
The EMBO Journal (1998)
Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases
David J. Rawlings;Andrew M. Scharenberg;Hyunsun Park;Matthew I. Wahl.
Phosphatidylinositol‐3,4,5‐trisphosphate (PtdIns‐3,4,5‐P3)/Tec kinase‐dependent calcium signaling pathway: a target for SHIP‐mediated inhibitory signals
Andrew M. Scharenberg;Ousama El-Hillal;David A. Fruman;Laurie O. Beitz.
The EMBO Journal (1998)
A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation
Elizabeth Clayton;Giuseppe Bardi;Sarah E. Bell;David Chantry.
Journal of Experimental Medicine (2002)
Impaired expansion of mouse B cell progenitors lacking Btk
James D. Kerner;Mark W. Appleby;Randolph N. Mohr;Sylvia Chien.
Regulation of Btk Function by a Major Autophosphorylation Site Within the SH3 Domain
Hyunsun Park;Matthew I Wahl;Daniel E.H Afar;Christoph W Turck.
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