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Immunology

D-Index
103
Citations
33887
World Ranking
650
National Ranking
379

Research.com Recognitions

  • 2019 - Distinguished Fellows of the American Association of Immunologists (AAI)

Overview

John C. Cambier is affiliated with the University of Colorado Anschutz Medical Campus in the United States. Their research primarily focuses on immunology and microbiology, with significant contributions to medicine. The core areas of their work include immunology, genetics, radiology, nuclear medicine and imaging, oncology, and molecular biology.

The scientist's work centers on topics related to T-cell and B-cell immunology, immune cell function and interaction, and research into diabetes and associated disorders. Other major themes include monoclonal and polyclonal antibodies research, IL-33, ST2, and ILC pathways, CAR-T cell therapy research, and pancreatic function related to diabetes.

Frequent publication venues for this researcher encompass:

  • Frontiers in Immunology
  • The Journal of Immunology
  • UNC Libraries
  • Current Opinion in Endocrinology Diabetes and Obesity
  • Biomedicines

Among their recently published papers are:

  • "Endotypes in T1D: B lymphocytes and early onset," 2020, Current Opinion in Endocrinology Diabetes and Obesity
  • "Therapeutic Targeting of Autoreactive B Cells: Why, How, and When?", 2021, Biomedicines
  • "Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells," 2023, Science Immunology
  • "A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation," 2023, The Journal of Experimental Medicine
  • "Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H," 2020, Frontiers in Immunology

John C. Cambier has collaborated frequently with peers including Andrew Getahun, Mia J. Smith, Peter A. Gottlieb, Bergren W. Crute, and Ryan M. Baxter.

Their research contributions have been recognized through inclusion in prestigious circles such as the Distinguished Fellows of the American Association of Immunologists (AAI), awarded in 2019.

Best Publications

  • Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

    Michael J. White;Michael J. White;Kate McArthur;Kate McArthur;Donald Metcalf;Donald Metcalf;Rachael M. Lane

  • B cell antigen receptor signaling 101.

    Joseph M Dal Porto;Stephen B Gauld;Kevin T Merrell;David Mills

  • Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM).

    J C Cambier

  • Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

    CM Pleiman;WM Hertz;JC Cambier

  • Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1.

    Daniele D'Ambrosio;Keli L. Hippen;Stacey A. Minskoff;Ira Mellman

  • Hypoxia-inducible factor-1 alpha–dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

    Eric T. Clambey;Eóin N. McNamee;Joseph A. Westrich;Louise E. Glover

  • Signal Transduction by the B Cell Antigen Receptor and its Coreceptors

    J C Cambier;C M Pleiman;M R Clark

  • MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

    Lei Jin;Paul M. Waterman;Karen R. Jonscher;Cindy M. Short

  • B-cell anergy: from transgenic models to naturally occurring anergic B cells?

    John C. Cambier;Stephen B. Gauld;Kevin T. Merrell;Barbara J. Vilen

  • Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes

    J C Cambier;M K Newell;L B Justement;J C McGuire

  • Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases.

    Lucia Olcese;Paul Lang;Frédéric Vély;Anna Cambiaggi;Anna Cambiaggi

  • The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors

    Marcus R. Clark;Kerry S. Campbell;Andrius Kazlauskas;Sara A. Johnson

  • Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4.

    Vanessa L Ott;John C Cambier;John Kappler;Philippa Marrack

  • B cell antigen receptor signaling: roles in cell development and disease.

    Stephen B. Gauld;Joseph M. Dal Porto;John C. Cambier

  • MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

    Lei Jin;Krista K. Hill;Holly Filak;Jennifer Mogan

  • New nomenclature for the Reth motif (or ARH1/TAM/ARAM/YXXL)

    John C. Cambier

  • Identification of Anergic B Cells within a Wild-Type Repertoire

    Kevin T. Merrell;Robert J. Benschop;Stephen B. Gauld;Katja Aviszus

  • Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45

    Louis B. Justement;Kerry S. Campbell;Nadine C. Chien;John C. Cambier

  • Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling.

    T. Kurosaki;S. A. Johnson;Lily Pao;K. Sada

  • Interleukin-induced increase in Ia expression by normal mouse B cells.

    N W Roehm;H J Leibson;A Zlotnik;J Kappler

Frequent Co-Authors

John G. Monroe
John G. Monroe University of Pennsylvania
Philippa Marrack
Philippa Marrack National Jewish Health
John W. Kappler
John W. Kappler National Jewish Health
Marc Daëron
Marc Daëron Institut Pasteur
Ellen S. Vitetta
Ellen S. Vitetta The University of Texas Southwestern Medical Center
Marcus R. Clark
Marcus R. Clark University of Chicago
Jonathan W. Uhr
Jonathan W. Uhr The University of Texas Southwestern Medical Center
David Nemazee
David Nemazee Scripps Research Institute
V. Michael Holers
V. Michael Holers University of Colorado Denver
Wendy L. Havran
Wendy L. Havran Scripps Research Institute

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