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Biology and Biochemistry

D-Index
57
Citations
8559
World Ranking
14103
National Ranking
5948

Research.com Recognitions

  • 2009 - AAI Distinguished Service Award, American Association of Immunologists For dedicated leadership as Chair of the AAI Program Committee, 2006-2009
  • 2005 - AAI Distinguished Service Award, American Association of Immunologists For dedicated leadership of the AAI Education Committee, 2002-2005, and as Director of the AAI Introductory Course in Immunology, 2003-2005

Overview

John G. Monroe is affiliated with the University of Pennsylvania in the United States. Their research primarily focuses on immunology and microbiology, with additional work in biochemistry, genetics, and molecular biology.

The main subfields of Monroe's work include immunology, cancer research, oncology, and molecular biology. The scientist's key research topics cover:

  • NF-κB Signaling Pathways
  • Immune Response and Inflammation
  • Cytokine Signaling Pathways and Interactions
  • Viral Infectious Diseases and Gene Expression in Insects
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology

Among recent publications are:

  • "Pharmacological Inhibition of MALT1 Ameliorates Autoimmune Pathogenesis and Can Be Uncoupled From Effects on Regulatory T-Cells", 2022, Frontiers in Immunology
  • "Allosteric Inhibition of MALT1 Is Efficacious in a Model of Chronic Graft-Versus-Host Disease and Modulates Immunometabolic Activation", 2021, Blood

Frequent publication venues for Monroe include:

  • Frontiers in Immunology
  • Blood

Monroe has collaborated frequently with several co-authors, including:

  • Subhabrata Biswas
  • Joanna R. DiSpirito
  • Brian A. DeChristopher
  • Andrew Long
  • Aditi Chalishazar

The scientist has been recognized with awards such as the AAI Distinguished Service Award from the American Association of Immunologists, received in 2005 and 2009. These awards acknowledge leadership roles within the AAI Program Committee, Education Committee, and contributions to the AAI Introductory Course in Immunology.

Best Publications

  • ITAM-mediated tonic signalling through pre-BCR and BCR complexes

    John G. Monroe

  • Transitional B cells: step by step towards immune competence

    James B. Chung;Michael Silverman;John G. Monroe

  • Negative Selection of Immature B Cells by Receptor Editing or Deletion Is Determined by Site of Antigen Encounter

    Peter C Sandel;John G Monroe

  • Engagement of the antigen-receptor on immature murine B lymphocytes results in death by apoptosis.

    A Norvell;L Mandik;J G Monroe

  • B-cell targeted therapies in human autoimmune diseases: an updated perspective

    Michael J. Townsend;John G. Monroe;Andrew C. Chan

  • Tonic B cell antigen receptor signals supply an NF-κB substrate for prosurvival BLyS signaling

    Jason E Stadanlick;Mary Kaileh;Fredrick G Karnell;Jean L Scholz

  • The role of early growth response gene 1 (egr-1) in regulation of the immune response.

    Steven B. McMahon;John G. Monroe

  • Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis.

    Gregory Bannish;Ezequiel M. Fuentes-Pananá;John C. Cambier;Warren S. Pear

  • Transcriptional regulation of the Icam-1 gene in antigen receptor- and phorbol ester-stimulated B lymphocytes: role for transcription factor EGR1.

    J S Maltzman;J A Carmen;J G Monroe

  • Fate decisions regulating bone marrow and peripheral B lymphocyte development.

    John G. Monroe;Kenneth Dorshkind

  • Role of primary response genes in generating cellular responses to growth factors.

    Steven B. McMahon;John G. Monroe

  • Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated differences in transmembrane signaling in splenic B cells from adult and neonatal mice.

    A. J. Yellen;W. Glenn;V. P. Sukhatme;Ximman Cao

  • MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture

    Elad Katz;Mohamed H. Lareef;John C. Rassa;Shannon M. Grande

  • Immunobiology of the immature B cell : plasticity in the B-cell antigen receptor-induced response fine tunes negative selection

    L B King;J G Monroe

  • B cell activation. I. Anti-immunoglobulin-induced receptor cross-linking results in a decrease in the plasma membrane potential of murine B lymphocytes.

    J G Monroe;J C Cambier

  • Lymphokine regulation of inflammatory processes: Interleukin-4 stimulates fibroblast proliferation

    John G. Monroe;Subrata Haldar;Michael B. Prystowsky;Patrick Lammie

  • CD23 defines two distinct subsets of immature B cells which differ in their responses to T cell help signals.

    James B. Chung;Richard A. Sater;Michele L. Fields;Jan Erikson

  • B cell activation. III. B cell plasma membrane depolarization and hyper-Ia antigen expression induced by receptor immunoglobulin cross-linking are coupled.

    J G Monroe;J C Cambier

  • B cell receptor-induced apoptosis in primary transitional murine B cells: signaling requirements and modulation by T cell help.

    Richard A. Sater;Peter C. Sandel;John G. Monroe

  • Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytes.

    J S Maltzman;J A Carman;J G Monroe

Frequent Co-Authors

John C. Cambier
John C. Cambier University of Colorado Anschutz Medical Campus
Mark I. Greene
Mark I. Greene University of Pennsylvania
Susan R. Ross
Susan R. Ross University of Illinois at Chicago
Steven B. McMahon
Steven B. McMahon Thomas Jefferson University
Leslie E. Silberstein
Leslie E. Silberstein Boston Children's Hospital
Vikas P. Sukhatme
Vikas P. Sukhatme Emory University
Michael S. McGrath
Michael S. McGrath University of California, San Francisco
Phyllis A. Gimotty
Phyllis A. Gimotty University of Pennsylvania
Jan Erikson
Jan Erikson The Wistar Institute
Brian Herndier
Brian Herndier University of California, San Diego

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