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Biology and Biochemistry

D-Index
49
Citations
14453
World Ranking
17846
National Ranking
7304

Overview

Steven B. McMahon is affiliated with Thomas Jefferson University in the United States. Their research spans multiple disciplines within biochemistry, genetics, molecular biology, and medicine. The primary fields of study include molecular biology, oncology, pulmonary and respiratory medicine, immunology, and pathology and forensic medicine.

The scientist has contributed extensively to topics such as RNA modifications and cancer, cancer-related molecular pathways, RNA research and splicing, RNA and protein synthesis mechanisms, genomics and chromatin dynamics, chromatin remodeling and cancer, and interferon and immune responses.

Recent papers authored or co-authored by Steven B. McMahon include:

  • Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates, 2021, Nature Communications
  • The SAGA complex regulates early steps in transcription via its deubiquitylase module subunit USP22, 2021, The EMBO Journal
  • Proton Beam Therapy in Breast Cancer Patients: The UK PARABLE Trial is Recruiting, 2023, Clinical Oncology
  • A β-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer, 2021, Cellular and Molecular Gastroenterology and Hepatology
  • ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial-to-mesenchymal transition in cranial neural crest specification, 2024, The American Journal of Human Genetics

Frequent co-authors in Steven B. McMahon's body of work include:

  • Samantha M. Barnada
  • Jonathan Karlin
  • Marina Farkaš
  • Timothy J. Stanek
  • Mason Tracewell

Key publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • The EMBO Journal
  • Clinical Oncology
  • The American Journal of Human Genetics

Their work often focuses on molecular interactions and mechanisms underlying cancer and genetic regulation, with studies addressing genome recognition by proteins such as p53, regulatory complexes like SAGA, and signaling pathways involved in cancer progression and therapeutic approaches such as proton beam therapy.

Best Publications

  • Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

    David R. Wise;Ralph J. Deberardinis;Anthony Mancuso;Nabil Sayed

  • The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

    Armen N. Akopian;Veronika Souslova;Steven England;Steven England;Kenji Okuse

  • The Novel ATM-Related Protein TRRAP Is an Essential Cofactor for the c-Myc and E2F Oncoproteins

    Steven B McMahon;Heather A Van Buskirk;Kerri A Dugan;Terry D Copeland

  • Acetylation of the p53 DNA-binding domain regulates apoptosis induction.

    Stephen M. Sykes;Hestia S. Mellert;Hestia S. Mellert;Marc A. Holbert;Keqin Li

  • The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc

    Steven B. McMahon;Marcelo A. Wood;Michael D. Cole

  • The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression.

    Xiao Yong Zhang;Maya Varthi;Stephen M. Sykes;Charles Phillips

  • Myc influences global chromatin structure.

    Paul S Knoepfler;Xiao Yong Zhang;Pei Feng Cheng;Philip R. Gafken

  • An ATPase/Helicase Complex Is an Essential Cofactor for Oncogenic Transformation by c-Myc

    Marcelo A Wood;Steven B McMahon;Michael D Cole

  • THE MYC ONCOPROTEIN : A CRITICAL EVALUATION OF TRANSACTIVATION AND TARGET GENE REGULATION

    Michael D Cole;Steven B McMahon

  • The c-MYC Oncoprotein Is a Substrate of the Acetyltransferases hGCN5/PCAF and TIP60

    Jagruti H. Patel;Yanping Du;Penny G. Ard;Charles Phillips

  • The p53 family and programmed cell death.

    E C Pietsch;S M Sykes;S B McMahon;M E Murphy

  • Analysis of genomic targets reveals complex functions of MYC

    Jagruti H. Patel;Andrey P. Loboda;Michael K. Showe;Louise C. Showe

  • Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

    Priya Aggarwal;Laura Pontano Vaites;Jong Kyong Kim;Hestia Mellert

  • MYC and the Control of Apoptosis

    Steven B. McMahon

  • Retraction Notice to: Nuclear Receptor Function Requires a TFTC-Type Histone Acetyl Transferase Complex

    Junn Yanagisawa;Hirochika Kitagawa;Mitsuaki Yanagida;Osamu Wada

  • The role of early growth response gene 1 (egr-1) in regulation of the immune response.

    Steven B. McMahon;John G. Monroe

  • The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis

    Jeonghyeon Park;Sudeesha Kunjibettu;Steven B. McMahon;Michael D. Cole

  • USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A.

    Xiao-yong Zhang;Harla K. Pfeiffer;Alan W. Thorne;Steven B McMahon

  • E2F transcriptional activation requires TRRAP and GCN5 cofactors.

    Steven E. Lang;Steven B. McMahon;Michael D. Cole;Patrick Hearing

  • Tra1p Is a Component of the Yeast Ada·Spt Transcriptional Regulatory Complexes

    Ayman Saleh;David Schieltz;Nicholas Ting;Steven B. McMahon

Frequent Co-Authors

Karen E. Knudsen
Karen E. Knudsen Thomas Jefferson University
John G. Monroe
John G. Monroe University of Pennsylvania
Hallgeir Rui
Hallgeir Rui Medical College of Wisconsin
Richard G. Pestell
Richard G. Pestell The Wistar Institute
Maureen E. Murphy
Maureen E. Murphy The Wistar Institute
Chenguang Wang
Chenguang Wang Johns Hopkins University
Kongming Wu
Kongming Wu Zhengzhou University
Shelley L. Berger
Shelley L. Berger University of Pennsylvania
Bruno Calabretta
Bruno Calabretta Thomas Jefferson University
Isidore Rigoutsos
Isidore Rigoutsos Thomas Jefferson University

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