World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
128
Citations
70501
World Ranking
2680
National Ranking
1498

Overview

Anne M. Fagan is affiliated with Washington University in St. Louis in the United States. Their research primarily spans the field of Medicine, with a focus on Psychiatry and Mental Health, Physiology, Neurology, Cognitive Neuroscience, and Molecular Biology.

The scientist's work covers multiple topics including Dementia and Cognitive Impairment Research, Alzheimer's Disease Research and Treatments, Functional Brain Connectivity Studies, Advanced Neuroimaging Techniques and Applications, Health, Environment, Cognitive Aging, Bioinformatics and Genomic Networks, and Amyloidosis: Diagnosis, Treatment, Outcomes.

Frequent publication venues for their research include Alzheimer's & Dementia, Journal of Alzheimer's Disease, Neurology, bioRxiv (Cold Spring Harbor Laboratory), and Brain.

Anne M. Fagan has contributed to a variety of recent papers of significance, including:

  • APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline (2020, Nature)
  • A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease (2020, Nature Medicine)
  • A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease (2021, Nature Medicine)
  • Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders (2021, Nature Neuroscience)
  • Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid (2022, Nature)

The scientist collaborates frequently with several co-authors, notably John C. Morris, Tammie L.S. Benzinger, Randall J. Bateman, Brian A. Gordon, and Carlos Cruchaga.

Best Publications

  • Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

    Reisa A. Sperling;Paul S. Aisen;Laurel A. Beckett;David A. Bennett

  • Clinical and Biomarker Changes in Dominantly Inherited Alzheimer’s Disease

    Randall J. Bateman;Chengjie Xiong;Tammie L.S. Benzinger;Anne M. Fagan

  • Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.

    Willemijn J. Jansen;Rik Ossenkoppele;Dirk L. Knol;Betty M. Tijms

  • Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction.

    Daniel A Nation;Melanie D Sweeney;Axel Montagne;Abhay P Sagare

  • Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

    Anne M. Fagan;Mark A. Mintun;Robert H. Mach;Sang-Yoon Lee

  • Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance

    Joseph M. Castellano;Jungsu Kim;Floy R. Stewart;Hong Jiang

  • ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

    Yang Shi;Kaoru Yamada;Shane Antony Liddelow;Shane Antony Liddelow;Scott T. Smith

  • APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

    Axel Montagne;Daniel A. Nation;Abhay P. Sagare;Giuseppe Barisano

  • Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

    David M. Holtzman;Kelly R. Bales;Tanya Tenkova;Anne M. Fagan

  • Cerebrospinal Fluid tau/β-Amyloid42 Ratio as a Prediction of Cognitive Decline in Nondemented Older Adults

    Anne M. Fagan;Catherine M. Roe;Chengjie Xiong;Mark A. Mintun

  • APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

    John C. Morris;Catherine M. Roe;Chengjie Xiong;Anne M. Fagan

  • Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

    Richard J. Perrin;Anne M. Fagan;David M. Holtzman

  • Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

    Oliver Preische;Oliver Preische;Stephanie A. Schultz;Anja Apel;Anja Apel;Jens Kuhle

  • High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis.

    Suzanne E. Schindler;James G. Bollinger;Vitaliy Ovod;Kwasi G. Mawuenyega

  • Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

    Matthew R Brier;Brian Gordon;Karl Friedrichsen;John E McCarthy

  • P-glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mouse model

    John R. Cirrito;Rashid Deane;Anne M. Fagan;Michael L. Spinner

  • Sleep Quality and Preclinical Alzheimer Disease

    Yo-El S. Ju;Jennifer S. McLeland;Cristina D. Toedebusch;Chengjie Xiong

  • Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study

    Stephanie J.B. Vos;Chengjie Xiong;Pieter Jelle Visser;Pieter Jelle Visser;Mateusz S. Jasielec

  • Exercise and Alzheimer's Disease Biomarkers in Cognitively Normal Older Adults

    Kelvin Y. Liang;Mark A. Mintun;Anne M. Fagan;Alison M. Goate

  • Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study

    Eric M Reiman;Yakeel T Quiroz;Yakeel T Quiroz;Adam S Fleisher;Kewei Chen

Frequent Co-Authors

John C. Morris
John C. Morris Washington University in St. Louis
David M. Holtzman
David M. Holtzman Washington University in St. Louis
Tammie L.S. Benzinger
Tammie L.S. Benzinger Washington University in St. Louis
Randall J. Bateman
Randall J. Bateman Washington University in St. Louis
Alison Goate
Alison Goate Icahn School of Medicine at Mount Sinai
Peter R. Schofield
Peter R. Schofield Neuroscience Research Australia
Beau M. Ances
Beau M. Ances Washington University in St. Louis
Stephen Salloway
Stephen Salloway Brown University
Ralph N. Martins
Ralph N. Martins Edith Cowan University
Reisa A. Sperling
Reisa A. Sperling Brigham and Women's Hospital

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