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Immunology

D-Index
61
Citations
14452
World Ranking
3219
National Ranking
1506

Overview

Leslie E. Silberstein is affiliated with Boston Children's Hospital in the United States. Their research focuses primarily on the fields of biochemistry, genetics, and molecular biology, with additional work in medicine and immunology and microbiology. The scientist's subfields of study include molecular biology, immunology, hematology, genetics, and physiology.

The main topics addressed in their research include:

  • Renal and related cancers
  • Cancer-related gene regulation
  • Epigenetics and DNA methylation
  • Neutrophil, myeloperoxidase, and oxidative mechanisms
  • Immune cells in cancer
  • Hemoglobinopathies and related disorders
  • Immune response and inflammation

Leslie E. Silberstein has published in several scientific venues, with a frequent presence in:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • Nature Immunology
  • Cell Reports

Notable recent publications include:

  • "Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection," 2020, Nature Immunology
  • "Zinc Finger Protein SALL4 Functions through an AT-Rich Motif to Regulate Gene Expression," 2021, Cell Reports
  • "Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversed by blood transfusion," 2020, Blood
  • "Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion," 2021, Science Translational Medicine
  • "Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy," 2021, Cancer Research

The scientist has collaborated extensively with several coauthors, including:

  • Hongbo R. Luo
  • Li Chai
  • Nikki R. Kong
  • Alicia Stein
  • Daniel G. Tenen

Best Publications

  • The elusive nature and function of mesenchymal stem cells.

    César Nombela-Arrieta;Jerome Ritz;Jerome Ritz;Leslie E. Silberstein

  • Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

    Xuemei Xie;Qiang Shi;Peng Wu;Xiaoyu Zhang

  • Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

    María Casanova-Acebes;Christophe Pitaval;Linnea A. Weiss;César Nombela-Arrieta

  • Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

    César Nombela-Arrieta;Gregory Pivarnik;Beatrice Winkel;Kimberly J. Canty

  • Bone Marrow Is a Major Reservoir and Site of Recruitment for Central Memory CD8+ T Cells

    Irina B. Mazo;Marek Honczarenko;Harry Leung;Lois L. Cavanagh

  • A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency

    Salima Hacein-Bey-Abina;Sung Yun Pai;H. Bobby Gaspar;Myriam Armant

  • Gasdermin D exerts anti-inflammatory effects by promoting neutrophil death

    Hiroto Kambara;Fei Liu;Xiaoyu Zhang;Xiaoyu Zhang;Peng Liu

  • Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.

    Corey Cutler;Pratik Multani;David Robbins;Haesook T. Kim

  • Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.

    Meike Burger;Aleksandra Glodek;Tanja Hartmann;Anette Schmitt-Gräff

  • The immunosuppressive macrolide RAD inhibits growth of human Epstein–Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders

    Miroslaw Majewski;Magdalena Korecka;Plamen Kossev;Shiyong Li

  • Production of autoantibodies by human-human hybridomas.

    Y Shoenfeld;S C Hsu-Lin;J E Gabriels;L E Silberstein

  • Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens.

    LE Silberstein;LC Jefferies;J Goldman;D Friedman

  • In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.

    Giovanni Amabile;Giovanni Amabile;Robert S. Welner;Robert S. Welner;Cesar Nombela-Arrieta;Cesar Nombela-Arrieta;Anna Morena D'Alise

  • Fgd5 identifies hematopoietic stem cells in the murine bone marrow

    Roi Gazit;Pankaj K. Mandal;Wataru Ebina;Ayal Ben-Zvi

  • Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells.

    Jianchang Yang;Li Chai;Fang Liu;Louis M. Fink

  • SDF-1 Responsiveness Does Not Correlate With CXCR4 Expression Levels of Developing Human Bone Marrow B Cells

    Marek Honczarenko;Raymond S. Douglas;Clarissa Mathias;Benhur Lee

  • Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells

    Philipp B. Staber;Philipp B. Staber;Philipp B. Staber;Pu Zhang;Min Ye;Robert S. Welner

  • Variation in blood component irradiation practice: implications for prevention of transfusion-associated graft-versus-host disease

    Kenneth C. Anderson;Lawrence T. Goodnough;Merlyn H Sayers;Patricia T. Pisciotto

  • Reducing the Risk for Transfusion-transmitted Cytomegalovirus Infection

    Merlin H. Sayers;Kenneth C. Anderson;Lawrence T. Goodnough;Sanford R. Kurtz

  • Leukocyte reduction in blood component therapy

    Thomas A. Lane;Kenneth C. Anderson;Lawrence T. Goodnough;Sanford Kurtz

  • Erratum: Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment (Nature Cell Biology (2013) 15 533-543))

    César Nombela-Arrieta;Gregory Pivarnik;Beatrice Winkel;Kimberly J. Canty

Frequent Co-Authors

Hongbo R. Luo
Hongbo R. Luo Boston Children's Hospital
Daniel G. Tenen
Daniel G. Tenen National University of Singapore
Jerome Ritz
Jerome Ritz Harvard University
Brendan A.C. Harley
Brendan A.C. Harley University of Illinois at Urbana-Champaign
Edward A. Stadtmauer
Edward A. Stadtmauer University of Pennsylvania
Alexei Protopopov
Alexei Protopopov The University of Texas MD Anderson Cancer Center
Peter C. Nowell
Peter C. Nowell University of Pennsylvania
John G. Monroe
John G. Monroe University of Pennsylvania
Steven L. Spitalnik
Steven L. Spitalnik Columbia University
Mariusz Z. Ratajczak
Mariusz Z. Ratajczak University of Louisville

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