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Biology and Biochemistry

D-Index
61
Citations
12100
World Ranking
11449
National Ranking
4947

Overview

Hongbo R. Luo is a researcher affiliated with Boston Children's Hospital in the United States. Their work spans several interconnected fields, primarily focusing on immunology and microbiology, biochemistry, genetics, molecular biology, and medicine.

Luo's publications reveal strong engagement with key topics such as neutrophil function, myeloperoxidase activity, oxidative mechanisms, inflammasomes, immune response and inflammation, immune cells related to cancer, heme oxygenase-1, carbon monoxide, immune cell function and interaction, and renal and related cancers.

  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Inflammasome and immune disorders
  • Immune Response and Inflammation
  • Immune cells in cancer
  • Heme Oxygenase-1 and Carbon Monoxide
  • Immune Cell Function and Interaction
  • Renal and related cancers

Luo has contributed to various subfields with the most publications in immunology and molecular biology. Other areas include hematology, epidemiology, and genetics, reflecting a broad and interdisciplinary approach to biomedical research.

  • Immunology
  • Molecular Biology
  • Hematology
  • Epidemiology
  • Genetics

The researcher has published numerous papers across prominent scientific venues. The most frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, SSRN Electronic Journal, Nature Communications, and Frontiers in Immunology.

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • SSRN Electronic Journal
  • Nature Communications
  • Frontiers in Immunology

Some notable recent papers by Luo include:

  • FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation (2020, Nature Immunology)
  • Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection (2020, Nature Immunology)
  • ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D (2024, Nature)
  • Single-cell transcriptomic landscape of human blood cells (2020, National Science Review)
  • The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis (2024, Science Immunology)

Luo frequently collaborates with several researchers, including Alan Y. Hsu, Fengxia Ma, Xuemei Xie, Hongbo Yu, and Li Chai. Collaboration counts with these coauthors range from 9 to 16 papers, indicating ongoing research partnerships.

Best Publications

  • FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

    Jun Jacob Hu;Jun Jacob Hu;Xing Liu;Xing Liu;Xing Liu;Shiyu Xia;Shiyu Xia;Zhibin Zhang;Zhibin Zhang

  • Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

    Xuemei Xie;Qiang Shi;Peng Wu;Xiaoyu Zhang

  • Gasdermin D exerts anti-inflammatory effects by promoting neutrophil death

    Hiroto Kambara;Fei Liu;Xiaoyu Zhang;Xiaoyu Zhang;Peng Liu

  • Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death

    Hakryul Jo;Subhanjan Mondal;Subhanjan Mondal;Dewar J. Tan;Dewar J. Tan;Eiichiro Nagata

  • Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways.

    H Luo;P Rose;D Barber;W P Hanratty

  • Constitutive neutrophil apoptosis: Mechanisms and regulation

    Hongbo R. Luo;Hongbo R. Luo;Fabien Loison;Fabien Loison

  • Akt as a mediator of cell death.

    Hongbo R. Luo;Hidenori Hattori;Mir Ahamed Hossain;Lynda Hester

  • The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

    Long–Jun Wu;Gongxiong Wu;M. Reza Akhavan Sharif;Amanda Baker

  • Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis.

    Miho Iijima;Yi Elaine Huang;Hongbo R. Luo;Francisca Vazquez

  • Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions.

    Hongbo R Luo;Yi Elaine Huang;Jianmeng C Chen;Adolfo Saiardi

  • Leukotriene B4 Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation

    Michiko K. Oyoshi;Rui He;Yitang Li;Subhanjan Mondal

  • A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect.

    Xia Liu;Chi Bun Chan;Sung Wuk Jang;Sompol Pradoldej

  • S-Nitrosylation of N-Ethylmaleimide Sensitive Factor Mediates Surface Expression of AMPA Receptors

    Yunfei Huang;Heng Ye Man;Yoko Sekine-Aizawa;Yefei Han

  • Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils.

    Jiro Sakai;Jingyu Li;Jingyu Li;Kulandayan Kulandayan K Subramanian;Subhanjan Mondal

  • Pike. A nuclear GTPase that enhances PI3kinase activity and is regulated by protein 4.1N

    Keqiang Ye;K.Joseph Hurt;Frederick Y Wu;Ming Fang

  • Phospholipase C|[gamma]|1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE

    Keqiang Ye;Bahman Aghdasi;Hongbo R. Luo;John L. Moriarity

  • Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis

    Hidenori Hattori;Kulandayan K. Subramanian;Jiro Sakai;Yonghui Jia

  • Stem Cell Factor SALL4 Represses the Transcriptions of PTEN and SALL1 through an Epigenetic Repressor Complex

    Jiayun Lu;Hawon Jeong;Nikki Kong;Youyang Yang

  • Identification and characterization of a novel inositol hexakisphosphate kinase.

    Adolfo Saiardi;Eiichiro Nagata;Hongbo R. Luo;Adele M. Snowman

  • PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells.

    H Luo;Y Yang;J Duan;P Wu

Frequent Co-Authors

Leslie E. Silberstein
Leslie E. Silberstein Boston Children's Hospital
Keqiang Ye
Keqiang Ye Shenzhen Institutes of Advanced Technology
Solomon H. Snyder
Solomon H. Snyder Johns Hopkins University School of Medicine
Daniel G. Tenen
Daniel G. Tenen National University of Singapore
Ivan Zanoni
Ivan Zanoni Boston Children's Hospital
Joseph P. Mizgerd
Joseph P. Mizgerd Boston University
Scott G. Filler
Scott G. Filler University of California, Los Angeles
Jose L. Lopez-Ribot
Jose L. Lopez-Ribot The University of Texas at San Antonio
Judy Lieberman
Judy Lieberman Boston Children's Hospital
Martha L. Bulyk
Martha L. Bulyk Harvard University

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