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Olli Silvennoinen

Olli Silvennoinen

D-Index & Metrics

Molecular Biology

D-Index
63
Citations
19893
World Ranking
1781
National Ranking
7

Overview

Olli Silvennoinen is affiliated with Tampere University in Finland and has contributed extensively to the field of medicine, with a particular focus on genetics, oncology, rheumatology, hematology, and molecular biology. Their research primarily addresses cytokine signaling pathways, myeloproliferative neoplasms, and rheumatoid arthritis, among other topics.

Their work includes investigations into rheumatoid arthritis therapies, acute myeloid leukemia, systemic lupus erythematosus, chronic myeloid leukemia treatments, and eosinophilic disorders and syndromes.

Frequent coauthors in Silvennoinen's research include Anniina Virtanen, T. Haikarainen, Pia Isomäki, Maaria Palmroth, and Ritva Peltomaa.

Olli Silvennoinen has published several papers, including the following:

  • Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates With Treatment Response, 2021, Frontiers in Immunology
  • JAK inhibitor selectivity: new opportunities, better drugs?, 2024, Nature Reviews Rheumatology
  • Janus Kinases in Leukemia, 2021, Cancers
  • Tofacitinib treatment modulates the levels of several inflammation-related plasma proteins in rheumatoid arthritis and baseline levels of soluble biomarkers associate with the treatment response, 2022, Clinical & Experimental Immunology
  • Differences in JAK Isoform Selectivity Among Different Types of JAK Inhibitors Evaluated for Rheumatic Diseases Through In Vitro Profiling, 2023, Arthritis & Rheumatology

Their research is frequently published in journals such as Frontiers in Immunology, Cancers, Pharmaceuticals, Science Advances, and FASEB BioAdvances.

Best Publications

  • JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

    Bruce A. Witthuhn;Frederick W. Quelle;Olli Silvennoinen;Taolin Yi

  • Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

    Lawrence S. Argetsinger;George S. Campbell;Xianjie Yang;Bruce A. Witthuhn

  • Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.

    Neil Stahl;Teri G. Boulton;Thomas Farruggella;Nancy Y. Ip

  • The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

    Mathias Müller;James Briscoe;Carl Laxton;Dmitry Guschin

  • Signaling by the cytokine receptor superfamily: JAKs and STATs

    James N. Ihle;Bruce A. Witthuhn;Frederick W. Quelle;Koh Yamamoto

  • SIGNALING THROUGH THE HEMATOPOIETIC CYTOKINE RECEPTORS

    James N. Ihle;Bruce A. Witthuhn;Frederick W. Quelle;Koh Yamamoto

  • Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

    Bruce A. Witthuhn;Olli Silvennoinen;Osamu Miura;Osamu Miura;Koon Siew Lai

  • The Janus kinases (Jaks)

    Kunihiro Yamaoka;Pipsa Saharinen;Marko Pesu;Vance E.T. Holt

  • Regulation of the Jak2 Tyrosine Kinase by Its Pseudokinase Domain

    Pipsa Saharinen;Kati Takaluoma;Olli Silvennoinen;Olli Silvennoinen

  • Interferon-induced nuclear signalling by Jak protein tyrosine kinases

    Olli Silvennoinen;James N. Ihle;Joseph Schlessinger;David E. Levy

  • The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.

    Pipsa Saharinen;Olli Silvennoinen;Olli Silvennoinen

  • Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.

    Masashi Narazaki;Bruce A. Witthuhn;Kanji Yoshida;Olli Silvennoinen

  • Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture.

    Anna L. Lahti;Ville J. Kujala;Hugh Chapman;Ari-Pekka Koivisto

  • Regulation of Jak2 through the Ubiquitin-Proteasome Pathway Involves Phosphorylation of Jak2 on Y1007 and Interaction with SOCS-1

    Daniela Ungureanu;Pipsa Saharinen;Ilkka Junttila;Douglas J. Hilton

  • The Pseudokinase Domain of JAK2 Is a Dual-Specificity Protein Kinase That Negatively Regulates Cytokine Signaling

    Daniela Ungureanu;Jinhua Wu;Jinhua Wu;Tuija Pekkala;Yashavanthi Niranjan

  • Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain.

    Pipsa Saharinen;Mauno Vihinen;Olli Silvennoinen

  • A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.

    James M. Murphy;James M. Murphy;Qingwei Zhang;Samuel N. Young;Michael L. Reese

  • Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

    Rajintha M Bandaranayake;Daniela Ungureanu;Yibing Shan;David E Shaw;David E Shaw

  • ARIP3 (Androgen Receptor-Interacting Protein 3) and Other PIAS (Protein Inhibitor of Activated STAT) Proteins Differ in Their Ability to Modulate Steroid Receptor-Dependent Transcriptional Activation

    Noora Kotaja;Saara Aittomäki;Olli Silvennoinen;Jorma J. Palvimo

  • Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradome.

    Jens F. Sundström;Alena Vaculova;Andrei P. Smertenko;Eugene I. Savenkov

Frequent Co-Authors

Stevan R. Hubbard
Stevan R. Hubbard New York University
Mika Rämet
Mika Rämet Oulu University Hospital
James N. Ihle
James N. Ihle St. Jude Children's Research Hospital
Xi Yang
Xi Yang University of Manitoba
Jorma J. Palvimo
Jorma J. Palvimo University of Eastern Finland
David E. Shaw
David E. Shaw D. E. Shaw Research
James M. Murphy
James M. Murphy Walter and Eliza Hall Institute of Medical Research
John J. O'Shea
John J. O'Shea National Institutes of Health
Jeffrey J. Babon
Jeffrey J. Babon Walter and Eliza Hall Institute of Medical Research
M. Celeste Simon
M. Celeste Simon University of Pennsylvania

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