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Biology and Biochemistry

D-Index
66
Citations
24222
World Ranking
8468
National Ranking
3808

Overview

Stevan R. Hubbard is affiliated with New York University in the United States. Their research spans multiple disciplines within medicine and biochemistry, genetics, and molecular biology.

The scientist has contributed extensively in the following fields of study:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Their work emphasizes several subfields, including:

  • Genetics
  • Immunology
  • Infectious Diseases
  • Molecular Biology
  • Oncology

Key topics covered in their research include:

  • Cytokine Signaling Pathways and Interactions
  • Protein Kinase Regulation and GTPase Signaling
  • Monoclonal and Polyclonal Antibodies Research
  • SARS-CoV-2 and COVID-19 Research
  • Virus-based gene therapy research
  • SARS-CoV-2 detection and testing
  • Myeloproliferative Neoplasms: Diagnosis and Treatment

Stevan R. Hubbard has published multiple research articles in well-known journals and repositories. Notable recent papers include:

  • Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations, 2020, Science
  • Increased resistance of SARS-CoV-2 Omicron variant to neutralization by vaccine-elicited and therapeutic antibodies, 2022, EBioMedicine
  • Structural basis of Janus kinase trans-activation, 2023, Cell Reports
  • Increased resistance of SARS-CoV-2 Omicron Variant to Neutralization by Vaccine-Elicited and Therapeutic Antibodies, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain, 2023, Pharmaceuticals

Frequent publication venues for this scientist include:

  • Science
  • bioRxiv (Cold Spring Harbor Laboratory)
  • EBioMedicine
  • Cell Reports
  • Pharmaceuticals

Stevan R. Hubbard has collaborated regularly with the following researchers:

  • K. Christopher García
  • Takuya Tada
  • Hao Zhou
  • Belinda M. Dcosta
  • Marie I. Samanovic

Best Publications

  • IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

    Marcella Calfon;Huiqing Zeng;Fumihiko Urano;Jeffery H Till

  • Protein Tyrosine Kinase Structure and Function

    Stevan R. Hubbard;Jeffrey H. Till

  • Crystal structure of the tyrosine kinase domain of the human insulin receptor.

    S. R. Hubbard;Lei Wei;L. Ellis;L. Ellis;W. A. Hendrickson;W. A. Hendrickson

  • Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.

    Moosa Mohammadi;Gerald McMahon;Li Sun;Cho Tang

  • Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog.

    Stevan R. Hubbard

  • Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

    Zhou Songyang;Zhou Songyang;Kermit L. Carraway;Michael J. Eck;Stephen C. Harrison

  • Structural basis for FGF receptor dimerization and activation.

    Alexander N Plotnikov;Joseph Schlessinger;Stevan R Hubbard;Moosa Mohammadi

  • Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK

    Natalie Kim;Amy L. Stiegler;Thomas O. Cameron;Peter T. Hallock

  • SU6668 Is a Potent Antiangiogenic and Antitumor Agent That Induces Regression of Established Tumors

    A. Douglas Laird;Peter Vajkoczy;Laura K. Shawver;Andreas Thurnher

  • Receptor tyrosine kinases: mechanisms of activation and signaling

    Stevan R Hubbard;W Todd Miller

  • Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.

    Moosa Mohammadi;Scott Froum;James M. Hamby;Mel C. Schroeder

  • Crystal Structures of Two FGF-FGFR Complexes Reveal the Determinants of Ligand-Receptor Specificity

    Alexander N Plotnikov;Stevan R Hubbard;Joseph Schlessinger;Moosa Mohammadi

  • Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism.

    Moosa Mohammadi;Joseph Schlessinger;Stevan R Hubbard

  • Autoregulatory Mechanisms in Protein-tyrosine Kinases

    Stevan R. Hubbard;Moosa Mohammadi;Joseph Schlessinger

  • Structure and autoregulation of the insulin-like growth factor 1 receptor kinase.

    S Favelyukis;J.H Till;S.R Hubbard;W.T. Miller

  • Juxtamembrane autoinhibition in receptor tyrosine kinases

    Stevan R Hubbard

  • Structural analysis of receptor tyrosine kinases.

    Stevan R Hubbard

  • The Pseudokinase Domain of JAK2 Is a Dual-Specificity Protein Kinase That Negatively Regulates Cytokine Signaling

    Daniela Ungureanu;Jinhua Wu;Jinhua Wu;Tuija Pekkala;Yashavanthi Niranjan

  • How IRE1 reacts to ER stress.

    David Ron;Stevan R. Hubbard

  • Mechanism-based design of a protein kinase inhibitor.

    Keykavous Parang;Jeffrey H. Till;Ararat J. Ablooglu;Ronald A. Kohanski

Frequent Co-Authors

Olli Silvennoinen
Olli Silvennoinen Tampere University
Moosa Mohammadi
Moosa Mohammadi New York University Langone Medical Center
Joseph Schlessinger
Joseph Schlessinger Yale University
Steven J. Burden
Steven J. Burden New York University
David E. Shaw
David E. Shaw D. E. Shaw Research
Wayne A. Hendrickson
Wayne A. Hendrickson Columbia University
Keykavous Parang
Keykavous Parang Chapman University
Philip A. Cole
Philip A. Cole Brigham and Women's Hospital
Mark R. Philips
Mark R. Philips New York University
Thomas A. Neubert
Thomas A. Neubert New York University

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